| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
in Human Neutrophils1
*
Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy;
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Geneva, Switzerland;
LeukoSite Inc., Cambridge, MA; and
§
Università di Brescia, Brescia, Italy
Human neutrophils (polymorphonuclear leukocytes; PMN) respond to
some CXC chemokines but do not migrate to CC chemokines. Recent work
has shown that chemokine receptors can be modulated by inflammatory
cytokines. In this study, the effect of IFN-
, a prototypic Th1
cytokine, on chemokine receptor expression in PMN was investigated.
IFN- caused a rapid (
1 h) and concentration-dependent increase of
CCR1 and CCR3 mRNA. The expression of CCR2, CCR5, and CXCR1–4 was not
augmented. IFN--treated PMN, but not control cells, expressed
specific binding sites for labeled monocyte-chemotactic protein (MCP)-3
and migrated to macrophage-inflammatory protein (MIP)-1
, RANTES,
MCP-3, MIP-5/HCC2, and eotaxin. 7B11, a mAb for CCR3, inhibited the
chemotactic response of IFN--treated PMN to eotaxin, and
aminoxypentane-RANTES blocked PMN migration to RANTES. These
results suggest that the selectivity of certain chemokines for their
target cells may be altered by cytokines produced within an
inflammatory context. Since PMN may play a role in orienting immunity
toward Th1 responses, it is possible to speculate that IFN- not only
promotes Th1 differentiation directly, but also reorients the
functional significance of Th2 effector cytokines by broadening the
spectrum of their action to include PMN.
This article has been cited by other articles:
|
|
 |
|
  D. Hartl, S. Krauss-Etschmann, B. Koller, P. L. Hordijk, T. W. Kuijpers, F. Hoffmann, A. Hector, E. Eber, V. Marcos, I. Bittmann, et al. Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases J. Immunol., December 1, 2008; 181(11): 8053 - 8067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Deruaz, A. Frauenschuh, A. L. Alessandri, J. M. Dias, F. M. Coelho, R. C. Russo, B. R. Ferreira, G. J. Graham, J. P. Shaw, T. N.C. Wells, et al. Ticks produce highly selective chemokine binding proteins with antiinflammatory activity J. Exp. Med., September 1, 2008; 205(9): 2019 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gouwy, S. Struyf, S. Noppen, E. Schutyser, J.-Y. Springael, M. Parmentier, P. Proost, and J. Van Damme Synergy between Coproduced CC and CXC Chemokines in Monocyte Chemotaxis through Receptor-Mediated Events Mol. Pharmacol., August 1, 2008; 74(2): 485 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Ramnath, J. Sun, S. Adhikari, L. Zhi, and M. Bhatia Role of PKC-{delta} on substance P-induced chemokine synthesis in pancreatic acinar cells Am J Physiol Cell Physiol, March 1, 2008; 294(3): C683 - C692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, R. D. Ramnath, and M. Bhatia Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils Am J Physiol Cell Physiol, August 1, 2007; 293(2): C696 - C704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Main, R. Handy, J. Wilton, S. Smith, L. Williams, L. D. Fou, J. Andrews, L. A. Conroy, R. May, I. Anderson, et al. A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1395 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Thirkill, H. Vedagiri, and G. C. Douglas Macaque Trophoblast Migration toward RANTES Is Inhibited by Cigarette Smoke-Conditioned Medium Toxicol. Sci., June 1, 2006; 91(2): 557 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Gladue, S. H. Cole, M. L. Roach, L. A. Tylaska, R. T. Nelson, R. M. Shepard, J. D. McNeish, K. T. Ogborne, and K. S. Neote The Human Specific CCR1 Antagonist CP-481,715 Inhibits Cell Infiltration and Inflammatory Responses in Human CCR1 Transgenic Mice. J. Immunol., March 1, 2006; 176(5): 3141 - 3148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Joubert, S. Lajoie-Kadoch, I. Labonte, A. S. Gounni, K. Maghni, V. Wellemans, J. Chakir, M. Laviolette, Q. Hamid, and B. Lamkhioued CCR3 Expression and Function in Asthmatic Airway Smooth Muscle Cells J. Immunol., August 15, 2005; 175(4): 2702 - 2708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Iida, T. Kohro, T. Kodama, S. Nagata, and R. Fukunaga Identification of CCR2, flotillin, and gp49B genes as new G-CSF targets during neutrophilic differentiation J. Leukoc. Biol., August 1, 2005; 78(2): 481 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Richter, R. Bistrian, S. Escher, W.-G. Forssmann, J. Vakili, R. Henschler, N. Spodsberg, A. Frimpong-Boateng, and U. Forssmann Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness J. Immunol., August 1, 2005; 175(3): 1599 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. L. Ramos, C. Canetti, J. T. Souto, J. S. Silva, C. M. Hogaboam, S. H. Ferreira, and F. Q. Cunha MIP-1{alpha}[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-{alpha} and LTB4 J. Leukoc. Biol., July 1, 2005; 78(1): 167 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bhatia, R. D. Ramnath, L. Chevali, and A. Guglielmotti Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1259 - G1265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Speyer, H. Gao, N. J. Rancilio, T. A. Neff, G. B. Huffnagle, J. V. Sarma, and P. A. Ward Novel Chemokine Responsiveness and Mobilization of Neutrophils during Sepsis Am. J. Pathol., December 1, 2004; 165(6): 2187 - 2196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Petkovic, C. Moghini, S. Paoletti, M. Uguccioni, and B. Gerber I-TAC/CXCL11 is a natural antagonist for CCR5 J. Leukoc. Biol., September 1, 2004; 76(3): 701 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gouwy, S. Struyf, J. Catusse, P. Proost, and J. Van Damme Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration J. Leukoc. Biol., July 1, 2004; 76(1): 185 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Bumbacea, J Scheerens, B S Mann, R G Stirling, and K F Chung Failure of sputum eosinophilia after eotaxin inhalation in asthma Thorax, May 1, 2004; 59(5): 372 - 375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Speyer, T. A. Neff, R. L. Warner, R.-F. Guo, J. V. Sarma, N. C. Riedemann, M. E. Murphy, H. S. Murphy, and P. A. Ward Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice Am. J. Pathol., December 1, 2003; 163(6): 2319 - 2328. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Phillips, V. E. L. Stubbs, M. R. Henson, T. J. Williams, J. E. Pease, and I. Sabroe Variations in Eosinophil Chemokine Responses: An Investigation of CCR1 and CCR3 Function, Expression in Atopy, and Identification of a Functional CCR1 Promoter J. Immunol., June 15, 2003; 170(12): 6190 - 6201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Bleharski, V. Kiessler, C. Buonsanti, P. A. Sieling, S. Stenger, M. Colonna, and R. L. Modlin A Role for Triggering Receptor Expressed on Myeloid Cells-1 in Host Defense During the Early-Induced and Adaptive Phases of the Immune Response J. Immunol., April 1, 2003; 170(7): 3812 - 3818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zeng, T. A. Moore, M. W. Newstead, R. Hernandez-Alcoceba, W. C. Tsai, and T. J. Standiford Intrapulmonary Expression of Macrophage Inflammatory Protein 1{alpha} (CCL3) Induces Neutrophil and NK Cell Accumulation and Stimulates Innate Immunity in Murine Bacterial Pneumonia Infect. Immun., March 1, 2003; 71(3): 1306 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Bhalla, P. G. Reinhart, C. Bai, and S. K. Gupta Amelioration of Ozone-Induced Lung Injury by Anti-Tumor Necrosis Factor-{alpha} Toxicol. Sci., October 1, 2002; 69(2): 400 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Menzies-Gow, S. Ying, I. Sabroe, V. L. Stubbs, D. Soler, T. J. Williams, and A. B. Kay Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages As Well As Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers J. Immunol., September 1, 2002; 169(5): 2712 - 2718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nagase, M. Miyamasu, M. Yamaguchi, M. Imanishi, N. H. Tsuno, K. Matsushima, K. Yamamoto, Y. Morita, and K. Hirai Cytokine-mediated regulation of CXCR4 expression in human neutrophils J. Leukoc. Biol., April 1, 2002; 71(4): 711 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Michalec, B. K. Choudhury, E. Postlethwait, J. S. Wild, R. Alam, M. Lett-Brown, and S. Sur CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation J. Immunol., January 15, 2002; 168(2): 846 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Kernacki, R. P Barrett, S. McClellan, and L. D. Hazlett MIP-1{alpha} regulates CD4+ T cell chemotaxis and indirectly enhances PMN persistence in Pseudomonas aeruginosa corneal infection J. Leukoc. Biol., December 1, 2001; 70(6): 911 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Chensue Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions Clin. Microbiol. Rev., October 1, 2001; 14(4): 821 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Dulkys, C. Kluthe, T. Buschermohle, I. Barg, S. Kno{beta}, A. Kapp, A. E. I. Proudfoot, and J. Elsner IL-3 Induces Down-Regulation of CCR3 Protein and mRNA in Human Eosinophils J. Immunol., September 15, 2001; 167(6): 3443 - 3453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Forssmann, H.-J. Magert, K. Adermann, S. E. Escher, and W.-G. Forssmann Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15 J. Leukoc. Biol., September 1, 2001; 70(3): 357 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Robson, R. M. McLoughlin, J. Witowski, P. Loetscher, T. S. Wilkinson, S. A. Jones, and N. Topley Differential Regulation of Chemokine Production in Human Peritoneal Mesothelial Cells: IFN-{{gamma}} Controls Neutrophil Migration Across the Mesothelium In Vitro and In Vivo J. Immunol., July 15, 2001; 167(2): 1028 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamashiro, H. Kamohara, J.-M. Wang, D. Yang, W.-H. Gong, and T. Yoshimura Phenotypic and functional change of cytokine-activated neutrophils: inflammatory neutrophils are heterogeneous and enhance adaptive immune responses J. Leukoc. Biol., May 1, 2001; 69(5): 698 - 704. [Abstract] [Full Text]
|
|
|
|
|
|
N. J. Coates and S. R. McColl Production of Chemokines In Vivo in Response to Microbial Stimulation J. Immunol., April 15, 2001; 166(8): 5176 - 5182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-F. Guo, A. B. Lentsch, R. L. Warner, M. Huber-Lang, J. V. Sarma, T. Hlaing, M. M. Shi, N. W. Lukacs, and P. A. Ward Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury J. Immunol., April 15, 2001; 166(8): 5208 - 5218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Cheng, J. J. Lai, N. W. Lukacs, and S. L. Kunkel Granulocyte-Macrophage Colony Stimulating Factor Up-Regulates CCR1 in Human Neutrophils J. Immunol., January 15, 2001; 166(2): 1178 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yamashiro, J.-M. Wang, D. Yang, W.-H. Gong, H. Kamohara, and T. Yoshimura Expression of CCR6 and CD83 by cytokine-activated human neutrophils Blood, December 1, 2000; 96(12): 3958 - 3963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-Z. Pan, L. Parkyn, A. Ray, and P. Ray Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L658 - L666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Zimmermann, B. L. Daugherty, J. L. Kavanaugh, F. Y. El-Awar, E. A. Moulton, and M. E. Rothenberg Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements Blood, October 1, 2000; 96(7): 2346 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Vicari, S. Ait-Yahia, K. Chemin, A. Mueller, A. Zlotnik, and C. Caux Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms J. Immunol., August 15, 2000; 165(4): 1992 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Belperio, M. D. Burdick, M. P. Keane, Y. Y. Xue, J. P. Lynch III, B. L. Daugherty, S. L. Kunkel, and R. M. Strieter The Role of the CC Chemokine, RANTES, in Acute Lung Allograft Rejection J. Immunol., July 1, 2000; 165(1): 461 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bonecchi, F. Facchetti, S. Dusi, W. Luini, D. Lissandrini, M. Simmelink, M. Locati, S. Bernasconi, P. Allavena, E. Brandt, et al. Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes J. Immunol., April 1, 2000; 164(7): 3862 - 3869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Lee, M. E. Brummet, S. Shahabuddin, T. G. Woodworth, S. N. Georas, K. M. Leiferman, S. C. Gilman, C. Stellato, R. P. Gladue, R. P. Schleimer, et al. Cutaneous Injection of Human Subjects with Macrophage Inflammatory Protein-1{alpha} Induces Significant Recruitment of Neutrophils and Monocytes J. Immunol., March 15, 2000; 164(6): 3392 - 3401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Elsner, M. Mack, H. Bruhl, Y. Dulkys, D. Kimmig, G. Simmons, P. R. Clapham, D. Schlondorff, A. Kapp, T. N. C. Wells, et al. Differential Activation of CC Chemokine Receptors by AOP-RANTES J. Biol. Chem., March 10, 2000; 275(11): 7787 - 7794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. I. Proudfoot, R. Buser, F. Borlat, S. Alouani, D. Soler, R. E. Offord, J.-M. Schroder, C. A. Power, and T. N. C. Wells Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors J. Biol. Chem., November 5, 1999; 274(45): 32478 - 32485. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
