| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
and TNF-
in Mouse Macrophages1
,¶,§,*,
*
Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206;
Department of Biochemistry and Molecular Genetics,
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine,
§
Department of Pharmacology, and
¶
Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262; and
||
Faculty of Medicine, Division of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
The expression of inducible nitric oxide synthase (iNOS) by
macrophages is stimulated by coexposure to IFN-
and a number of
stimuli, including TNF-
. Recent work has shown that TNF-
activates members of the mitogen-activated protein kinase family that
subsequently trans-activate transcription factors
implicated in the regulation of iNOS expression. The objective of this
study was to systematically evaluate the role of: 1)
p42mapk/erk2, 2) p46 c-Jun
NH2-terminal kinase/stress-activated protein kinase (p46
JNK/SAPK), and 3) p38mapk in the
induction of iNOS expression during costimulation of mouse macrophages
with IFN- and TNF-. All three kinases were activated during
costimulation with IFN- and TNF-. However, specific antagonism of
the p42mapk/erk2 and
p38mapk with PD98059 and SKF86002,
respectively, had no effect on the induction of iNOS expression. In
contrast, blockade of all three kinases with
N-acetylcysteine completely blocked the induction of iNOS
expression. In addition, specific antagonism of the JNK/SAPK upstream
kinases MEKK (mitogen-activated protein kinase/extracellular
signal-regulated kinase kinase kinase) and MKK4 (mitogen-activated
protein kinase kinase 4) with dominant inhibitory mutants blocked
transcriptional activation of the iNOS promoter in response to
costimulation with IFN- and TNF-. Collectively, these findings
support the involvement of p46 JNK/SAPK and its upstream kinases in
regulating the induction of iNOS following ligation of the TNF-
receptor CD120a (p55) in the presence of IFN-.
This article has been cited by other articles:
|
|
 |
|
  H. W. Jeong, K. C. Hsu, J.-W. Lee, M. Ham, J. Y. Huh, H. J. Shin, W. S. Kim, and J. B. Kim Berberine suppresses proinflammatory responses through AMPK activation in macrophages Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E955 - E964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vila-del Sol, C. Punzon, and M. Fresno IFN-{gamma}-Induced TNF-{alpha} Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages J. Immunol., October 1, 2008; 181(7): 4461 - 4470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Schett, J Zwerina, and G Firestein The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis Ann Rheum Dis, July 1, 2008; 67(7): 909 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Blanchette, P. Pouliot, and M. Olivier Role of protein tyrosine phosphatases in the regulation of interferon-{gamma}-induced macrophage nitric oxide generation: implication of ERK pathway and AP-1 activation J. Leukoc. Biol., March 1, 2007; 81(3): 835 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vila-del Sol, M. D. Diaz-Munoz, and M. Fresno Requirement of tumor necrosis factor {alpha} and nuclear factor-{kappa}B in the induction by IFN-{gamma} of inducible nitric oxide synthase in macrophages J. Leukoc. Biol., January 1, 2007; 81(1): 272 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Jiang and D. S. Pisetsky The Role of IFN-{alpha} and Nitric Oxide in the Release of HMGB1 by RAW 264.7 Cells Stimulated with Polyinosinic-Polycytidylic Acid or Lipopolysaccharide. J. Immunol., September 1, 2006; 177(5): 3337 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Steer, J. M. Moran, B. S. Christmann, L. B. Maggi Jr, and J. A. Corbett Role of MAPK in the Regulation of Double-Stranded RNA- and Encephalomyocarditis Virus-Induced Cyclooxygenase-2 Expression by Macrophages. J. Immunol., September 1, 2006; 177(5): 3413 - 3420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yan, J. Li, W. Ouyang, Q. Ma, Y. Hu, D. Zhang, J. Ding, Q. Qu, K. Subbaramaiah, and C. Huang NFAT3 is specifically required for TNF-{alpha}-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells J. Cell Sci., July 15, 2006; 119(14): 2985 - 2994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Frankel, G. P. Cosgrove, S.-I. Cha, C. D. Cool, M. W. Wynes, B. L. Edelman, K. K. Brown, and D. W. H. Riches TNF-{alpha} Sensitizes Normal and Fibrotic Human Lung Fibroblasts to Fas-Induced Apoptosis Am. J. Respir. Cell Mol. Biol., March 1, 2006; 34(3): 293 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Frankel, B. M. Moats-Staats, C. D. Cool, M. W. Wynes, A. D. Stiles, and D. W. H. Riches Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L805 - L812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhu, G. Krishnegowda, and D. C. Gowda Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum: THE REQUIREMENT OF EXTRACELLULAR SIGNAL-REGULATED KINASE, p38, c-Jun N-TERMINAL KINASE AND NF-{kappa}B PATHWAYS FOR THE EXPRESSION OF PROINFLAMMATORY CYTOKINES AND NITRIC OXIDE J. Biol. Chem., March 4, 2005; 280(9): 8617 - 8627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Wynes, S. K. Frankel, and D. W. H. Riches IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal J. Leukoc. Biol., November 1, 2004; 76(5): 1019 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ikezumi, L. Hurst, R. C. Atkins, and D. J. Nikolic-Paterson Macrophage-Mediated Renal Injury Is Dependent on Signaling via the JNK Pathway J. Am. Soc. Nephrol., July 1, 2004; 15(7): 1775 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Kang, T.-S. Chang, T.-H. Lee, E. S. Kim, D.-Y. Yu, and S. G. Rhee Cytosolic Peroxiredoxin Attenuates The Activation Of Jnk And P38 But Potentiates That Of Erk In Hela Cells Stimulated With Tumor Necrosis Factor-{alpha} J. Biol. Chem., January 23, 2004; 279(4): 2535 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Dockrell, H. M. Marriott, L. R. Prince, V. C. Ridger, P. G. Ince, P. G. Hellewell, and M. K. B. Whyte Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection J. Immunol., November 15, 2003; 171(10): 5380 - 5388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Yadav, Z. Liu, and M. M. Rafi A Diarylheptanoid from Lesser Galangal (Alpinia officinarum) Inhibits Proinflammatory Mediators via Inhibition of Mitogen-Activated Protein Kinase, p44/42, and Transcription Factor Nuclear Factor-{kappa}B J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 925 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Maggi Jr., J. M. Moran, R. M. L. Buller, and J. A. Corbett ERK Activation Is Required for Double-stranded RNA- and Virus-induced Interleukin-1 Expression by Macrophages J. Biol. Chem., May 2, 2003; 278(19): 16683 - 16689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Morris, R. D. Lutz, H.-S. Choi, T. Kamitani, K. Chmura, and E. D. Chan Role of the NF-{kappa}B Signaling Pathway and {kappa}B cis-Regulatory Elements on the IRF-1 and iNOS Promoter Regions in Mycobacterial Lipoarabinomannan Induction of Nitric Oxide Infect. Immun., March 1, 2003; 71(3): 1442 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-W. Park, J.-R. Kim, S.-Y. Kim, J.-K. Sonn, O.-S. Bang, S.-S. Kang, J.-H. Kim, and S.-H. Baek Akt as a Mediator of Secretory Phospholipase A2 Receptor-Involved Inducible Nitric Oxide Synthase Expression J. Immunol., February 15, 2003; 170(4): 2093 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Dwivedi, C. S. T. Hii, A. Ferrante, J. Tan, C. J. Der, J. L. Omdahl, H. A. Morris, and B. K. May Role of MAP Kinases in the 1,25-Dihydroxyvitamin D3-induced Transactivation of the Rat Cytochrome P450C24 (CYP24) Promoter. SPECIFIC FUNCTIONS FOR ERK1/ERK2 AND ERK5 J. Biol. Chem., August 9, 2002; 277(33): 29643 - 29653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Gregory and E. J. Wing Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections J. Leukoc. Biol., August 1, 2002; 72(2): 239 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Hsu and M.-H. Wen Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression J. Biol. Chem., June 14, 2002; 277(25): 22131 - 22139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-H. Lo, Y.-C. Liang, S.-Y. Lin-Shiau, C.-T. Ho, and J.-K. Lin Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-{kappa}B in mouse macrophages Carcinogenesis, June 1, 2002; 23(6): 983 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Chan, J. Chan, and N. W. Schluger What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis? . Current Knowledge Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 606 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Chan, A. H. Ralston, and L. Shapiro Does Reduced {alpha}1-Antitrypsin Activity Explain the Link Between Cigarette Smoking and Idiopathic Pulmonary Fibrosis? Chest, July 1, 2001; 120(2007): 72S - 74S. [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Hsu, K.-H. Chi, W.-C. Huang, and W.-W. Lin Ceramide Inhibits Lipopolysaccharide-Mediated Nitric Oxide Synthase and Cyclooxygenase-2 Induction in Macrophages: Effects on Protein Kinases and Transcription Factors J. Immunol., May 1, 2001; 166(9): 5388 - 5397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Chan, K. R. Morris, J. T. Belisle, P. Hill, L. K. Remigio, P. J. Brennan, and D. W. H. Riches Induction of Inducible Nitric Oxide Synthase-NO{middle dot} by Lipoarabinomannan of Mycobacterium tuberculosis Is Mediated by MEK1-ERK, MKK7-JNK, and NF-{kappa}B Signaling Pathways Infect. Immun., April 1, 2001; 69(4): 2001 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chayama, P. J. Papst, T. P. Garrington, J. C. Pratt, T. Ishizuka, S. Webb, S. Ganiatsas, L. I. Zon, W. Sun, G. L. Johnson, et al. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells PNAS, March 22, 2001; (2001) 81021898. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. D. Chan and D. W. H. Riches IFN-{gamma} + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line Am J Physiol Cell Physiol, March 1, 2001; 280(3): C441 - C450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ropert, I. C. Almeida, M. Closel, L. R. Travassos, M. A. J. Ferguson, P. Cohen, and R. T. Gazzinelli Requirement of Mitogen-Activated Protein Kinases and I{{kappa}}B Phosphorylation for Induction of Proinflammatory Cytokines Synthesis by Macrophages Indicates Functional Similarity of Receptors Triggered by Glycosylphosphatidylinositol Anchors from Parasitic Protozoa and Bacterial Lipopolysaccharide J. Immunol., March 1, 2001; 166(5): 3423 - 3431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chen, S.-L. Hsieh, and W.-W. Lin Involvement of protein kinases in the potentiation of lipopolysaccharide-induced inflammatory mediator formation by thapsigargin in peritoneal macrophages J. Leukoc. Biol., February 1, 2001; 69(2): 280 - 288. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Krishna Rao MAP kinase activation in macrophages J. Leukoc. Biol., January 1, 2001; 69(1): 3 - 10. [Abstract] [Full Text]
|
|
|
|
|
|
A. Morikawa, N. Koide, Y. Kato, T. Sugiyama, D. Chakravortty, T. Yoshida, and T. Yokochi Augmentation of Nitric Oxide Production by Gamma Interferon in a Mouse Vascular Endothelial Cell Line and Its Modulation by Tumor Necrosis Factor Alpha and Lipopolysaccharide Infect. Immun., November 1, 2000; 68(11): 6209 - 6214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Murakami, K. Kawabata, T. Koshiba, G. Gao, Y. Nakamura, K. Koshimizu, and H. Ohigashi Nitric Oxide Synthase Is Induced in Tumor Promoter-sensitive, but not Tumor Promoter-resistant, JB6 Mouse Epidermal Cells Cocultured with Interferon- {{gamma}}-stimulated RAW 264.7 Cells: The Role of Tumor Necrosis Factor-{{alpha}} Cancer Res., November 1, 2000; 60(22): 6326 - 6331. [Abstract] [Full Text]
|
|
|
|
|
|
Y. J. Jeon, Y. K. Kim, M. Lee, S. M. Park, S. B. Han, and H. M. Kim Radicicol Suppresses Expression of Inducible Nitric-Oxide Synthase by Blocking p38 Kinase and Nuclear Factor-kappa B/Rel in Lipopolysaccharide-Stimulated Macrophages J. Pharmacol. Exp. Ther., August 1, 2000; 294(2): 548 - 554. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Browning, M. P. McShane, C. Marty, and R. D. Ye Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase J. Biol. Chem., January 28, 2000; 275(4): 2811 - 2816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hirasawa, H. S. Jun, H. S. Han, M. L. Zhang, M. D. Hollenberg, and J. W. Yoon Prevention of Encephalomyocarditis Virus-Induced Diabetes in Mice by Inhibition of the Tyrosine Kinase Signalling Pathway and Subsequent Suppression of Nitric Oxide Production in Macrophages J. Virol., October 1, 1999; 73(10): 8541 - 8548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bellmann, V. Burkart, J. Bruckhoff, H. Kolb, and J. Landry p38-dependent Enhancement of Cytokine-induced Nitric-oxide Synthase Gene Expression by Heat Shock Protein 70 J. Biol. Chem., June 9, 2000; 275(24): 18172 - 18179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Hsu and Y.-C. Twu Tumor Necrosis Factor-alpha -mediated Protein Kinases in Regulation of Scavenger Receptor and Foam Cell Formation on Macrophage J. Biol. Chem., December 22, 2000; 275(52): 41035 - 41048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Hsu, S.-L. Chiu, M.-H. Wen, K.-Y. Chen, and K.-F. Hua Ligands of Macrophage Scavenger Receptor Induce Cytokine Expression via Differential Modulation of Protein Kinase Signaling Pathways J. Biol. Chem., July 27, 2001; 276(31): 28719 - 28730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chayama, P. J. Papst, T. P. Garrington, J. C. Pratt, T. Ishizuka, S. Webb, S. Ganiatsas, L. I. Zon, W. Sun, G. L. Johnson, et al. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells PNAS, April 10, 2001; 98(8): 4599 - 4604. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
