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ß T Cell Pool1
*
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115; and
Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095
It is generally accepted that TCR 
ß+
CD8+ T cells recognize immunogenic peptides bound to
MHC-encoded class I molecules. This recognition is a major component of
the cellular response mediating immune protection and recovery from
viral infections and from certain intracellular bacterial infections.
Here, we report two human CD8+ TCR ß+ T
cell lines specific for Mycobacterium tuberculosis Ags
presented in the context of CD1a or CD1c Ag-presenting molecules. These
T cells recognize lipid Ags and display cytotoxicity as well as strong
Th cell type I cytokine responses. By extending presentation by the CD1
system to the major TCR ß+ CD8+ T cell
pool, this system gains wider applicability beyond the double negative
subset of T cells previously shown to have this reactivity. This
implies that previous assumptions about the role of CD8+ T
cells in microbial immunity may require revision as the relative
proportions of CD1-restricted and MHC class I-restricted
CD8+ T cells are further defined.
This article has been cited by other articles:
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 J. E. Gumperz CD1d-restricted "NKT" cells and myeloid IL-12 production: an immunological crossroads leading to promotion or suppression of effective anti-tumor immune responses? J. Leukoc. Biol., August 1, 2004; 76(2): 307 - 313. [Abstract] [Full Text] [PDF]
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 D. A. Lewinsohn, A. S. Heinzel, J. M. Gardner, L. Zhu, M. R. Alderson, and D. M. Lewinsohn Mycobacterium tuberculosis-specific CD8+ T Cells Preferentially Recognize Heavily Infected Cells Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1346 - 1352. [Abstract] [Full Text] [PDF]
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A. L. Gervassi, P. Probst, W. E. Stamm, J. Marrazzo, K. H. Grabstein, and M. R. Alderson Functional Characterization of Class Ia- and Non-Class Ia-Restricted Chlamydia-Reactive CD8+ T Cell Responses in Humans J. Immunol., October 15, 2003; 171(8): 4278 - 4286. [Abstract] [Full Text] [PDF]
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T. Kawashima, Y. Norose, Y. Watanabe, Y. Enomoto, H. Narazaki, E. Watari, S. Tanaka, H. Takahashi, I. Yano, M. B. Brenner, et al. Cutting Edge: Major CD8 T Cell Response to Live Bacillus Calmette-Guerin Is Mediated by CD1 Molecules J. Immunol., June 1, 2003; 170(11): 5345 - 5348. [Abstract] [Full Text] [PDF]
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C. C. Dascher, K. Hiromatsu, X. Xiong, M. Sugita, J. E. Buhlmann, I. L. Dodge, S. Y. Lee, C. Roura-Mir, G. F. Watts, C. J. Roy, et al. Conservation of CD1 Intracellular Trafficking Patterns Between Mammalian Species J. Immunol., December 15, 2002; 169(12): 6951 - 6958. [Abstract] [Full Text] [PDF]
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V. Lazarevic and J. Flynn CD8+ T Cells in Tuberculosis Am. J. Respir. Crit. Care Med., October 15, 2002; 166(8): 1116 - 1121. [Full Text] [PDF]
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K. Hiromatsu, C. C. Dascher, K. P. LeClair, M. Sugita, S. T. Furlong, M. B. Brenner, and S. A. Porcelli Induction of CD1-Restricted Immune Responses in Guinea Pigs by Immunization with Mycobacterial Lipid Antigens J. Immunol., July 1, 2002; 169(1): 330 - 339. [Abstract] [Full Text] [PDF]
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E. P. Grant, E. M. Beckman, S. M. Behar, M. Degano, D. Frederique, G. S. Besra, I. A. Wilson, S. A. Porcelli, S. T. Furlong, and M. B. Brenner Fine Specificity of TCR Complementarity-Determining Region Residues and Lipid Antigen Hydrophilic Moieties in the Recognition of a CD1-Lipid Complex J. Immunol., April 15, 2002; 168(8): 3933 - 3940. [Abstract] [Full Text] [PDF]
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R. van Crevel, T. H. M. Ottenhoff, and J. W. M. van der Meer Innate Immunity to Mycobacterium tuberculosis Clin. Microbiol. Rev., April 1, 2002; 15(2): 294 - 309. [Abstract] [Full Text] [PDF]
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A. Giuliani, S. P. Prete, G. Graziani, A. Aquino, A. Balduzzi, M. Sugita, M. B. Brenner, E. Iona, L. Fattorini, G. Orefici, et al. Influence of Mycobacterium bovis Bacillus Calmette Guerin on In Vitro Induction of CD1 Molecules in Human Adherent Mononuclear Cells Infect. Immun., December 1, 2001; 69(12): 7461 - 7470. [Abstract] [Full Text] [PDF]
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C. G. Feng, C. Demangel, A. T. Kamath, M. Macdonald, and W. J. Britton Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8+ T cells with specificity for a novel mycobacterial epitope Int. Immunol., April 1, 2001; 13(4): 451 - 458. [Abstract] [Full Text] [PDF]
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B. Wang, T. Chun, I. C. Rulifson, M. Exley, S. P. Balk, and C.-R. Wang Human CD1d Functions as a Transplantation Antigen and a Restriction Element in Mice J. Immunol., March 15, 2001; 166(6): 3829 - 3836. [Abstract] [Full Text] [PDF]
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M. M. Altamirano, A. Woolfson, A. Donda, A. Shamshiev, L. Briseno-Roa, N. W. Foster, D. B. Veprintsev, G. De Libero, A. R. Fersht, and C. Milstein From the Cover: Ligand-independent assembly of recombinant human CD1 by using oxidative refolding chromatography PNAS, March 13, 2001; 98(6): 3288 - 3293. [Abstract] [Full Text] [PDF]
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 G.A.W. Rook, G. Seah, and A. Ustianowski M. tuberculosis: immunology and vaccination Eur. Respir. J., March 1, 2001; 17(3): 537 - 557. [Abstract] [Full Text] [PDF]
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G. Lertmemongkolchai, G. Cai, C. A. Hunter, and G. J. Bancroft Bystander Activation of CD8+ T Cells Contributes to the Rapid Production of IFN-{{gamma}} in Response to Bacterial Pathogens J. Immunol., January 15, 2001; 166(2): 1097 - 1105. [Abstract] [Full Text] [PDF]
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D. M. Lewinsohn, L. Zhu, V. J. Madison, D. C. Dillon, S. P. Fling, S. G. Reed, K. H. Grabstein, and M. R. Alderson Classically Restricted Human CD8+ T Lymphocytes Derived from Mycobacterium tuberculosis-Infected Cells: Definition of Antigenic Specificity J. Immunol., January 1, 2001; 166(1): 439 - 446. [Abstract] [Full Text] [PDF]
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S. M. Smith, M. R. Klein, A. S. Malin, J. Sillah, K. Huygen, P. Andersen, K. P. W. J. McAdam, and H. M. Dockrell Human CD8+ T Cells Specific for Mycobacterium tuberculosis Secreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia Infect. Immun., December 1, 2000; 68(12): 7144 - 7148. [Abstract] [Full Text] [PDF]
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D. B. Moody, M. R. Guy, E. Grant, T.-Y. Cheng, M. B. Brenner, G. S. Besra, and S. A. Porcelli CD1b-mediated T Cell Recognition of a Glycolipid Antigen Generated from Mycobacterial Lipid and Host Carbohydrate during Infection J. Exp. Med., October 2, 2000; 192(7): 965 - 976. [Abstract] [Full Text] [PDF]
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 M. J. Soloski, M. E. Szperka, A. Davies, and S. L. Wooden Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules Experimental Biology and Medicine, September 1, 2000; 224(4): 231 - 239. [Abstract] [Full Text]
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D. H. Geho, J. D. Fayen, R. M. Jackman, D. B. Moody, S. A. Porcelli, and M. L. Tykocinski Glycosyl-Phosphatidylinositol Reanchoring Unmasks Distinct Antigen-Presenting Pathways for CD1b and CD1c J. Immunol., August 1, 2000; 165(3): 1272 - 1277. [Abstract] [Full Text] [PDF]
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V. Briken, R. M. Jackman, G. F.M. Watts, R. A. Rogers, and S. A. Porcelli Human CD1b and CD1c Isoforms Survey Different Intracellular Compartments for the Presentation of Microbial Lipid Antigens J. Exp. Med., July 17, 2000; 192(2): 281 - 288. [Abstract] [Full Text] [PDF]
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D. M. Lewinsohn, A. L. Briden, S. G. Reed, K. H. Grabstein, and M. R. Alderson Mycobacterium tuberculosis-Reactive CD8+ T Lymphocytes: The Relative Contribution of Classical Versus Nonclassical HLA Restriction J. Immunol., July 15, 2000; 165(2): 925 - 930. [Abstract] [Full Text] [PDF]
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E. Carbone, G. Terrazzano, A. Melian, D. Zanzi, L. Moretta, S. Porcelli, K. Karre, and S. Zappacosta Inhibition of Human NK Cell-Mediated Killing by CD1 Molecules J. Immunol., June 15, 2000; 164(12): 6130 - 6137. [Abstract] [Full Text] [PDF]
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P. A. Sieling, M.-T. Ochoa, D. Jullien, D. S. Leslie, S. Sabet, J.-P. Rosat, A. E. Burdick, T. H. Rea, M. B. Brenner, S. A. Porcelli, et al. Evidence for Human CD4+ T Cells in the CD1-Restricted Repertoire: Derivation of Mycobacteria-Reactive T Cells from Leprosy Lesions J. Immunol., May 1, 2000; 164(9): 4790 - 4796. [Abstract] [Full Text] [PDF]
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U. E. Schaible, K. Hagens, K. Fischer, H. L. Collins, and S. H. E. Kaufmann Intersection of Group I CD1 Molecules and Mycobacteria in Different Intracellular Compartments of Dendritic Cells J. Immunol., May 1, 2000; 164(9): 4843 - 4852. [Abstract] [Full Text] [PDF]
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C. C. Dascher, K. Hiromatsu, J. W. Naylor, P. P. Brauer, K. A. Brown, J. R. Storey, S. M. Behar, E. S. Kawasaki, S. A. Porcelli, M. B. Brenner, et al. Conservation of a CD1 Multigene Family in the Guinea Pig J. Immunol., November 15, 1999; 163(10): 5478 - 5488. [Abstract] [Full Text] [PDF]
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S. M. Smith, A. S. Malin, Pauline T., Lukey, S. E. Atkinson, J. Content, K. Huygen, and H. M. Dockrell Characterization of Human Mycobacterium bovis Bacille Calmette-Guerin-Reactive CD8+ T Cells Infect. Immun., October 1, 1999; 67(10): 5223 - 5230. [Abstract] [Full Text] [PDF]
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A. Melian, Y.-J. Geng, G. K. Sukhova, P. Libby, and S. A. Porcelli CD1 Expression in Human Atherosclerosis : A Potential Mechanism for T Cell Activation by Foam Cells Am. J. Pathol., September 1, 1999; 155(3): 775 - 786. [Abstract] [Full Text] [PDF]
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M. Han, L. Harrison, P. Kehn, K. Stevenson, J. Currier, and M. A. Robinson Invariant or Highly Conserved TCR {alpha} Are Expressed on Double-Negative (CD3+CD4-CD8-) and CD8+ T Cells J. Immunol., July 1, 1999; 163(1): 301 - 311. [Abstract] [Full Text] [PDF]
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E. P. Grant, M. Degano, J.-P. Rosat, S. Stenger, R. L. Modlin, I. A. Wilson, S. A. Porcelli, and M. B. Brenner Molecular Recognition of Lipid Antigens by T Cell Receptors J. Exp. Med., January 4, 1999; 189(1): 195 - 205. [Abstract] [Full Text] [PDF]
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M. Sugita, N. van der Wel, R. A. Rogers, P. J. Peters, and M. B. Brenner CD1c molecules broadly survey the endocytic system PNAS, July 18, 2000; 97(15): 8445 - 8450. [Abstract] [Full Text] [PDF]
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