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T Cells and WC1+ CD8- T Cells In Vitro1
*
Department of Veterinary Pathology and Microbiology, Washington State University, Pullman, WA 99164; and
Center for Animal Biotechnology, Institute of Biosciences and Technology, Texas A&M University, College Station, TX 77843
Type I IFNs have a broad array of immunoregulatory functions that
include up-regulation of type 1 immune responses through enhancing
differentiation and activation of CD8+ T cells and
CD4+ Th1 cells. Ovine trophoblast IFN-
is a recently
described type I IFN with the potential for therapeutic use, based on
its potent antiviral activity yet low toxicity. Studies were designed
to determine the immunoregulatory effects of IFN- on Ag-stimulated T
cells, and a novel effect of type I IFNs on 
T cells was
observed. In cultures of parasite Ag-stimulated bovine T cells that
contained a mixture of 
ß and T cells, both IFN- and
IFN- suppressed the expansion of WC1+ CD2-
CD6- CD8- T cells, yet stimulated the
growth of WC1- CD2+ CD6+
CD8+ T cells and CD8+ ß T cells.
The CD8+ T cell subset expressed high levels of the
IL-2R -chain. Furthermore, we showed that type I IFN enhanced IL-2
production by these Ag-stimulated T cell lines. In short term cultures
of PBMC, IL-2 stimulated an expansion of WC1-
CD6+ CD8+ T cells, which was
significantly increased by IFN-, even though IFN- alone did not
support cell survival. These studies demonstrate for the first time
that type I IFNs differentially modulate the proliferation of different
subsets of T cells, which appears to act in part via
IL-2.
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