| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Immunology Research Division, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115
Both IL-4 and IL-10 are regulatory cytokines produced by Th2 cells
that can down-regulate cell-mediated immune responses. The studies
reported here examine the influence of various cytokines in the
regulation of T cell IL-10 production. The results indicate that IL-10
gene expression by TCR transgenic Th2 cells is significantly
up-regulated by IL-4 in the absence of TCR signals. IL-4 enhances both
IL-10 mRNA levels and secreted protein, and this effect is not related
to enhanced mRNA stability. TCR-mediated IL-10 gene expression is
inhibited by cyclosporin A, but IL-4-mediated IL-10 expression is not.
IL-4 also enhances IL-13 mRNA levels, to a lesser extent than IL-10,
but does not significantly effect the expression of other cytokine
mRNAs. Furthermore, IL-4 does not significantly enhance IL-10
expression in Th1 cells. IL-2 also enhances effector cytokine
production in the absence of TCR signals, but in a subset nonspecific
manner, increasing both Th2 IL-4 mRNA and Th1 IFN-
mRNA. These data
suggest that Th2 IL-4 production may contribute to the down-regulation
of immune responses by directly enhancing Th2 IL-10 production. In
addition, the data clearly demonstrate that exogenous cytokines can
significantly influence effector cytokine production by effector T
cells without the requirement for TCR signals.
This article has been cited by other articles:
|
|
 |
|
  M. R. King, A. S. Ismail, L. S. Davis, and D. R. Karp Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype. J. Immunol., March 1, 2006; 176(5): 2765 - 2772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Schmidt-Weber, M. Letarte, S. Kunzmann, B. Ruckert, C. Bernabeu, and K. Blaser TGF-{beta} signaling of human T cells is modulated by the ancillary TGF-{beta} receptor endoglin Int. Immunol., July 1, 2005; 17(7): 921 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Furukawa, K. Oshima, T. Tung, G. Cui, H. Laks, and L. Sen Liposome-Mediated Combinatorial Cytokine Gene Therapy Induces Localized Synergistic Immunosuppression and Promotes Long-Term Survival of Cardiac Allografts J. Immunol., June 1, 2005; 174(11): 6983 - 6992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Wohlfahrt, C. Karagiannidis, S. Kunzmann, M. M. Epstein, W. Kempf, K. Blaser, and C. B. Schmidt-Weber Ephrin-A1 Suppresses Th2 Cell Activation and Provides a Regulatory Link to Lung Epithelial Cells J. Immunol., January 15, 2004; 172(2): 843 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stephens, D. A. Randolph, G. Huang, M. J. Holtzman, and D. D. Chaplin Antigen-Nonspecific Recruitment of Th2 Cells to the Lung as a Mechanism for Viral Infection-Induced Allergic Asthma J. Immunol., November 15, 2002; 169(10): 5458 - 5467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Jump and A. D. Levine Murine Peyer's Patches Favor Development of an IL-10-Secreting, Regulatory T Cell Population J. Immunol., June 15, 2002; 168(12): 6113 - 6119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Lim, H. Xie, C. E. Come, S. I. Alexander, M. J. Grusby, A. H. Lichtman, and F. W. Luscinskas IL-12, STAT4-Dependent Up-Regulation of CD4+ T Cell Core 2 {beta}-1,6-n-Acetylglucosaminyltransferase, an Enzyme Essential for Biosynthesis of P-Selectin Ligands J. Immunol., October 15, 2001; 167(8): 4476 - 4484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jankovic, M. C. Kullberg, N. Noben-Trauth, P. Caspar, W. E. Paul, and A. Sher Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile J. Immunol., March 15, 2000; 164(6): 3047 - 3055. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
