| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Center for Molecular Medicine and Therapeutics and
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Stromal cell-derived factor-1 (SDF-1), a C-X-C family chemokine, is a potent T lymphocyte chemoattractant. We investigated the effects of T cell activation on the chemotactic response to SDF-1. Anti-CD3 Ab stimulation of either Jurkat T cells or murine peripheral CD4+ T lymphocytes produced a dramatic inhibition of SDF-1-induced chemotaxis. In contrast, the SDF-1 responses of Jurkat clones with deficiencies in key TCR signaling components (Lck, CD45, and TCR-ß), were only marginally reduced by anti-CD3 stimulation. Similar to PMA treatment, which abolished both CXCR4 receptor expression and the chemotactic response of Jurkat cells to SDF-1, anti-CD3 Ab treatment reduced cell surface expression of CXCR4 to 65% of the control value, an effect that was blocked by protein kinase C inhibitors. Our data suggest that initial T cell activation events inhibit the response of Jurkat T cells to CXCR4 stimulation. In contrast, SDF-1 treatment resulted in a reduction of tyrosine phosphorylation of the TCR downstream effectors, ZAP-70, SLP-76, and LAT (linker for activation of T cells), suggesting that this chemokine potentially regulates the threshold for T cell activation.
This article has been cited by other articles:
|
|
 |
|
  O. D. Schneider, A. A. Weiss, and W. E. Miller Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR4 J. Immunol., May 1, 2009; 182(9): 5730 - 5739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Peacock, J. Palmer, D. Fink, S. Ip, E. M. Pietras, A. L.-F. Mui, S. W. Chung, M. E. Gleave, M. E. Cox, R. Parsons, et al. PTEN Loss Promotes Mitochondrially Dependent Type II Fas-Induced Apoptosis via PEA-15 Mol. Cell. Biol., March 1, 2009; 29(5): 1222 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Campbell and S. A. Spector CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+ T Cells J. Biol. Chem., November 7, 2008; 283(45): 30745 - 30753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Zaman, M. E. Resek, and S. M. Robbins Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line J. Leukoc. Biol., October 1, 2008; 84(4): 1082 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Malavasi, S. Deaglio, A. Funaro, E. Ferrero, A. L. Horenstein, E. Ortolan, T. Vaisitti, and S. Aydin Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology Physiol Rev, July 1, 2008; 88(3): 841 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Lobo, K. H. Schlegel, C. E. Spencer, M. D. Okusa, C. Chisholm, N. Mchedlishvili, A. Park, C. Christ, and C. Burtner Naturally Occurring IgM Anti-Leukocyte Autoantibodies (IgM-ALA) Inhibit T Cell Activation and Chemotaxis J. Immunol., February 1, 2008; 180(3): 1780 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sohy, M. Parmentier, and J.-Y. Springael Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers J. Biol. Chem., October 12, 2007; 282(41): 30062 - 30069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. DeFord-Watts, J. A. Young, L. A. Pitcher, and N. S. C. van Oers The Membrane-proximal Portion of CD3 {epsilon} Associates with the Serine/Threonine Kinase GRK2 J. Biol. Chem., June 1, 2007; 282(22): 16126 - 16134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tan, D. Martin, and J. S. Gutkind The G{alpha}13-Rho Signaling Axis Is Required for SDF-1-induced Migration through CXCR4 J. Biol. Chem., December 22, 2006; 281(51): 39542 - 39549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Deaglio, T. Vaisitti, S. Aydin, E. Ferrero, and F. Malavasi In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia Blood, August 15, 2006; 108(4): 1135 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vianello, N. Papeta, T. Chen, P. Kraft, N. White, W. K. Hart, M. F. Kircher, E. Swart, S. Rhee, G. Palu, et al. Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control. J. Immunol., March 1, 2006; 176(5): 2902 - 2914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zaitseva, T. Romantseva, J. Manischewitz, J. Wang, D. Goucher, and H. Golding Increased CXCR4-dependent HIV-1 fusion in activated T cells: role of CD4/CXCR4 association J. Leukoc. Biol., December 1, 2005; 78(6): 1306 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vincent, Y. Collette, R. Marignier, C. Vuaillat, V. Rogemond, N. Davoust, C. Malcus, S. Cavagna, A. Gessain, I. Machuca-Gayet, et al. A Role for the Neuronal Protein Collapsin Response Mediator Protein 2 in T Lymphocyte Polarization and Migration J. Immunol., December 1, 2005; 175(11): 7650 - 7660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vianello, P. Kraft, Y. T. Mok, W. K. Hart, N. White, and M. C. Poznansky A CXCR4-Dependent Chemorepellent Signal Contributes to the Emigration of Mature Single-Positive CD4 Cells from the Fetal Thymus J. Immunol., October 15, 2005; 175(8): 5115 - 5125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Balabanian, J. Harriague, C. Decrion, B. Lagane, S. Shorte, F. Baleux, J.-L. Virelizier, F. Arenzana-Seisdedos, and L. A. Chakrabarti CXCR4-Tropic HIV-1 Envelope Glycoprotein Functions as a Viral Chemokine in Unstimulated Primary CD4+ T Lymphocytes J. Immunol., December 15, 2004; 173(12): 7150 - 7160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hecht, R. Hershkoviz, S. Shivtiel, T. Lapidot, I. R. Cohen, O. Lider, and L. Cahalon Heparin-disaccharide affects T cells: inhibition of NF-{kappa}B activation, cell migration, and modulation of intracellular signaling J. Leukoc. Biol., June 1, 2004; 75(6): 1139 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inngjerdingen, B. Rolstad, and J. C. Ryan Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12 J. Immunol., September 15, 2003; 171(6): 2889 - 2895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Z. Fernandis, R. P. Cherla, and R. K. Ganju Differential Regulation of CXCR4-mediated T-cell Chemotaxis and Mitogen-activated Protein Kinase Activation by the Membrane Tyrosine Phosphatase, CD45 J. Biol. Chem., March 7, 2003; 278(11): 9536 - 9543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mo, J. Chen, Y. Han, C. Bueno-Cannizares, D. E. Misek, P. A. Lescure, S. Hanash, and R. L. Yung T Cell Chemokine Receptor Expression in Aging J. Immunol., January 15, 2003; 170(2): 895 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hecht, L. Cahalon, R. Hershkoviz, A. Lahat, S. Franitza, and O. Lider Heterologous desensitization of T cell functions by CCR5 and CXCR4 ligands: inhibition of cellular signaling, adhesion and chemotaxis Int. Immunol., January 1, 2003; 15(1): 29 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Y. Choe, E. S. Schoenberger, J. E. Groopman, and I.-W. Park HIV Nef Inhibits T Cell Migration J. Biol. Chem., November 22, 2002; 277(48): 46079 - 46084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fox, K. Ung, S. G. Tanlimco, and F. R. Jirik Disruption of a Single Pten Allele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1 J. Immunol., July 1, 2002; 169(1): 49 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inngjerdingen, K. M. Torgersen, and A. A. Maghazachi Lck is required for stromal cell-derived factor 1alpha (CXCL12)-induced lymphoid cell chemotaxis Blood, May 29, 2002; 99(12): 4318 - 4325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ticchioni, C. Charvet, N. Noraz, L. Lamy, M. Steinberg, A. Bernard, and M. Deckert Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration Blood, May 1, 2002; 99(9): 3111 - 3118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Blanchard, D. Lankar, F. Faure, A. Regnault, C. Dumont, G. Raposo, and C. Hivroz TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/{zeta} Complex J. Immunol., April 1, 2002; 168(7): 3235 - 3241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hernandez-Lopez, A. Varas, R. Sacedon, E. Jimenez, J. J. Munoz, A. G. Zapata, and A. Vicente Stromal cell-derived factor 1/CXCR4 signaling is critical for early human T-cell development Blood, January 15, 2002; 99(2): 546 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Suzuki, M. Rahman, and H. Mitsuya Diverse Transcriptional Response of CD4+ T Cells to Stromal Cell-Derived Factor (SDF)-1: Cell Survival Promotion and Priming Effects of SDF-1 on CD4+ T Cells J. Immunol., September 15, 2001; 167(6): 3064 - 3073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Ottoson, J. T. Pribila, A. S. H. Chan, and Y. Shimizu Cutting Edge: T Cell Migration Regulated by CXCR4 Chemokine Receptor Signaling to ZAP-70 Tyrosine Kinase J. Immunol., August 15, 2001; 167(4): 1857 - 1861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Colamussi, P. Secchiero, A. Gonelli, M. Marchisio, G. Zauli, and S. Capitani Stromal derived factor-1{alpha} (SDF-1{alpha}) induces CD4+ T cell apoptosis via the functional up-regulation of the Fas (CD95)/Fas ligand (CD95L) pathway J. Leukoc. Biol., February 1, 2001; 69(2): 263 - 270. [Abstract] [Full Text]
|
|
|
|
|
|
T. Nanki, K. Hayashida, H. S. El-Gabalawy, S. Suson, K. Shi, H. J. Girschick, S. Yavuz, and P. E. Lipsky Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium J. Immunol., December 1, 2000; 165(11): 6590 - 6598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bromley, D. A. Peterson, M. D. Gunn, and M. L. Dustin Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation J. Immunol., July 1, 2000; 165(1): 15 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Gonzalo, C. M. Lloyd, A. Peled, T. Delaney, A. J. Coyle, and J.-C. Gutierrez-Ramos Critical Involvement of the Chemotactic Axis CXCR4/Stromal Cell-Derived Factor-1{alpha} in the Inflammatory Component of Allergic Airway Disease J. Immunol., July 1, 2000; 165(1): 499 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nanki and P. E. Lipsky Cutting Edge: Stromal Cell-Derived Factor-1 Is a Costimulator for CD4+ T Cell Activation J. Immunol., May 15, 2000; 164(10): 5010 - 5014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Secchiero, D. Zella, S. Curreli, P. Mirandola, S. Capitani, R. C. Gallo, and G. Zauli Engagement of CD28 Modulates CXC Chemokine Receptor 4 Surface Expression in Both Resting and CD3-Stimulated CD4+ T Cells J. Immunol., April 15, 2000; 164(8): 4018 - 4024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sotsios, G. C. Whittaker, J. Westwick, and S. G. Ward The CXC Chemokine Stromal Cell-Derived Factor Activates a Gi-Coupled Phosphoinositide 3-Kinase in T Lymphocytes J. Immunol., December 1, 1999; 163(11): 5954 - 5963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Orsini, J.-L. Parent, S. J. Mundell, and J. L. Benovic Trafficking of the HIV Coreceptor CXCR4. ROLE OF ARRESTINS AND IDENTIFICATION OF RESIDUES IN THE C-TERMINAL TAIL THAT MEDIATE RECEPTOR INTERNALIZATION J. Biol. Chem., October 22, 1999; 274(43): 31076 - 31086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Ansel, L. J. McHeyzer-Williams, V. N. Ngo, M. G. McHeyzer-Williams, and J. G. Cyster In Vivo-Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines J. Exp. Med., October 18, 1999; 190(8): 1123 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Su, W. Gong, M. Grimm, I. Utsunomiya, R. Sargeant, J. J. Oppenheim, and J. Ming Wang Inhibition of Tyrosine Kinase Activation Blocks the Down-Regulation of CXC Chemokine Receptor 4 by HIV-1 gp120 in CD4+ T Cells J. Immunol., June 15, 1999; 162(12): 7128 - 7132. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
