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*
Laboratory of Clinical Investigation and
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CC-chemokine receptor (CCR) 6 is the only known receptor for
macrophage inflammatory protein (MIP)-3
, a CC chemokine chemotactic
for lymphocytes and dendritic cells. Using anti-serum that we
raised against the N-terminal residues of CCR6, we have characterized
the surface expression of CCR6 on peripheral blood leukocytes and we
have correlated CCR6 expression with responses to MIP-3. We found
that CCR6 was expressed only on memory T cells, including most
4ß7 memory cells and cutaneous
lymphocyte-associated Ag-expressing cells, and on B cells. Accordingly,
chemotaxis of T cells to MIP-3 was limited to memory cells.
Moreover, calcium signals on T cells in response to MIP-3 were
confined to CCR6-expressing cells, consistent with CCR6 being the only
MIP-3 receptor on peripheral blood T cells. Unlike many CC
chemokines, MIP-3 produced a calcium signal on freshly isolated T
cells, and CCR6 expression was not increased by up to 5 days of
treatment with IL-2 or by cross-linking CD3. Despite their surface
expression of CCR6, freshly isolated B cells did not respond to
MIP-3. In addition to staining peripheral blood leukocytes, our
anti-serum detected CCR6 on CD34+ bone marrow
cell-derived dendritic cells. Our data are the first to analyze surface
expression of CCR6, demonstrating receptor expression on
differentiated, resting memory T cells, indicating differences in
receptor signaling on T cells and B cells and suggesting that CCR6 and
MIP-3 may play a role in the physiology of resting memory T cells
and in the interactions of memory T cells, B cells, and dendritic
cells.
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|
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|
|
|
|
|
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|
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|
 |
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|
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|
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