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*
Laboratory of Clinical Investigation and
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CC-chemokine receptor (CCR) 6 is the only known receptor for
macrophage inflammatory protein (MIP)-3
, a CC chemokine chemotactic
for lymphocytes and dendritic cells. Using anti-serum that we
raised against the N-terminal residues of CCR6, we have characterized
the surface expression of CCR6 on peripheral blood leukocytes and we
have correlated CCR6 expression with responses to MIP-3. We found
that CCR6 was expressed only on memory T cells, including most
4ß7 memory cells and cutaneous
lymphocyte-associated Ag-expressing cells, and on B cells. Accordingly,
chemotaxis of T cells to MIP-3 was limited to memory cells.
Moreover, calcium signals on T cells in response to MIP-3 were
confined to CCR6-expressing cells, consistent with CCR6 being the only
MIP-3 receptor on peripheral blood T cells. Unlike many CC
chemokines, MIP-3 produced a calcium signal on freshly isolated T
cells, and CCR6 expression was not increased by up to 5 days of
treatment with IL-2 or by cross-linking CD3. Despite their surface
expression of CCR6, freshly isolated B cells did not respond to
MIP-3. In addition to staining peripheral blood leukocytes, our
anti-serum detected CCR6 on CD34+ bone marrow
cell-derived dendritic cells. Our data are the first to analyze surface
expression of CCR6, demonstrating receptor expression on
differentiated, resting memory T cells, indicating differences in
receptor signaling on T cells and B cells and suggesting that CCR6 and
MIP-3 may play a role in the physiology of resting memory T cells
and in the interactions of memory T cells, B cells, and dendritic
cells.
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M. Casamayor-Palleja, P. Mondiere, C. Verschelde, C. Bella, and T. Defrance BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially Blood, March 15, 2002; 99(6): 1913 - 1921. [Abstract] [Full Text] [PDF]
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Y. Imaizumi, S. Sugita, K. Yamamoto, D. Imanishi, T. Kohno, M. Tomonaga, and T. Matsuyama Human T cell leukemia virus type-I Tax activates human macrophage inflammatory protein-3{alpha}/CCL20 gene transcription via the NF-{kappa}B pathway Int. Immunol., February 1, 2002; 14(2): 147 - 155. [Abstract] [Full Text] [PDF]
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L. M. Ebert and S. R. McColl Up-Regulation of CCR5 and CCR6 on Distinct Subpopulations of Antigen-Activated CD4+ T Lymphocytes J. Immunol., January 1, 2002; 168(1): 65 - 72. [Abstract] [Full Text] [PDF]
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 F. Sierro, B. Dubois, A. Coste, D. Kaiserlian, J.-P. Kraehenbuhl, and J.-C. Sirard Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells PNAS, November 20, 2001; 98(24): 13722 - 13727. [Abstract] [Full Text] [PDF]
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M.-C. Dieu-Nosjean, C. Massacrier, B. Vanbervliet, W.-H. Fridman, and C. Caux IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-{gamma} Suppress It J. Immunol., November 15, 2001; 167(10): 5594 - 5602. [Abstract] [Full Text] [PDF]
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B. Dubois, C. Massacrier, and C. Caux Selective attraction of naive and memory B cells by dendritic cells J. Leukoc. Biol., October 1, 2001; 70(4): 633 - 641. [Abstract] [Full Text] [PDF]
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S. Fujiie, K. Hieshima, D. Izawa, T. Nakayama, R. Fujisawa, H. Ohyanagi, and O. Yoshie Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3{alpha}/CCL20 in mucosal epithelial cells through NF-{kappa}B Int. Immunol., October 1, 2001; 13(10): 1255 - 1263. [Abstract] [Full Text] [PDF]
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N. W. Lukacs, D. M. Prosser, M. Wiekowski, S. A. Lira, and D. N. Cook Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation J. Exp. Med., August 20, 2001; 194(4): 551 - 556. [Abstract] [Full Text] [PDF]
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G. Penna, S. Sozzani, and L. Adorini Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells J. Immunol., August 15, 2001; 167(4): 1862 - 1866. [Abstract] [Full Text] [PDF]
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A. Izadpanah, M. B. Dwinell, L. Eckmann, N. M. Varki, and M. F. Kagnoff Regulated MIP-3{alpha}/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity Am J Physiol Gastrointest Liver Physiol, April 1, 2001; 280(4): G710 - G719. [Abstract] [Full Text] [PDF]
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K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi Chemokine Receptor Expressions and Responsiveness of Cord Blood T Cells J. Immunol., February 1, 2001; 166(3): 1659 - 1666. [Abstract] [Full Text] [PDF]
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 P. Conti, R. C. Barbacane, C. Feliciani, and M. Reale Expression and Secretion of RANTES by Human Peripheral Blood CD4+ Cells are Dependent on the Presence of Monocytes Ann. Clin. Lab. Sci., January 1, 2001; 31(1): 75 - 84. [Abstract] [Full Text] [PDF]
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T. Nakayama, R. Fujisawa, H. Yamada, T. Horikawa, H. Kawasaki, K. Hieshima, D. Izawa, S. Fujiie, T. Tezuka, and O. Yoshie Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3{{alpha}}/CCL20 by epidermal keratinocytes and its role in atopic dermatitis Int. Immunol., January 1, 2001; 13(1): 95 - 103. [Abstract] [Full Text] [PDF]
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D. P. Andrew, N. Ruffing, C. H. Kim, W. Miao, H. Heath, Y. Li, K. Murphy, J. J. Campbell, E. C. Butcher, and L. Wu C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential J. Immunol., January 1, 2001; 166(1): 103 - 111. [Abstract] [Full Text] [PDF]
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D. J. Fitzhugh, S. Naik, S. W. Caughman, and S. T. Hwang Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro J. Immunol., December 15, 2000; 165(12): 6677 - 6681. [Abstract] [Full Text] [PDF]
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B. Serafini, S. Columba-Cabezas, F. Di Rosa, and F. Aloisi Intracerebral Recruitment and Maturation of Dendritic Cells in the Onset and Progression of Experimental Autoimmune Encephalomyelitis Am. J. Pathol., December 1, 2000; 157(6): 1991 - 2002. [Abstract] [Full Text] [PDF]
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K. A. Papadakis, J. Prehn, V. Nelson, L. Cheng, S. W. Binder, P. D. Ponath, D. P. Andrew, and S. R. Targan The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System J. Immunol., November 1, 2000; 165(9): 5069 - 5076. [Abstract] [Full Text] [PDF]
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E. Schutyser, S. Struyf, P. Menten, J.-P. Lenaerts, R. Conings, W. Put, A. Wuyts, P. Proost, and J. Van Damme Regulated Production and Molecular Diversity of Human Liver and Activation-Regulated Chemokine/Macrophage Inflammatory Protein-3{alpha} from Normal and Transformed Cells J. Immunol., October 15, 2000; 165(8): 4470 - 4477. [Abstract] [Full Text] [PDF]
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R. Krzysiek, E. A. Lefevre, J. Bernard, A. Foussat, P. Galanaud, F. Louache, and Y. Richard Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha /CCL20 in human B cells Blood, October 1, 2000; 96(7): 2338 - 2345. [Abstract] [Full Text] [PDF]
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D. Unutmaz, W. Xiang, M. J. Sunshine, J. Campbell, E. Butcher, and D. R. Littman The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse J. Immunol., September 15, 2000; 165(6): 3284 - 3292. [Abstract] [Full Text] [PDF]
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M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al. Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors J. Exp. Med., September 5, 2000; 192(5): 705 - 718. [Abstract] [Full Text] [PDF]
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B. Homey, M.-C. Dieu-Nosjean, A. Wiesenborn, C. Massacrier, J.-J. Pin, E. Oldham, D. Catron, M. E. Buchanan, A. Muller, R. deWaal Malefyt, et al. Up-Regulation of Macrophage Inflammatory Protein-3{alpha}/CCL20 and CC Chemokine Receptor 6 in Psoriasis J. Immunol., June 15, 2000; 164(12): 6621 - 6632. [Abstract] [Full Text] [PDF]
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C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
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E. P. Bowman, J. J. Campbell, D. Soler, Z. Dong, N. Manlongat, D. Picarella, R. R. Hardy, and E. C. Butcher Developmental Switches in Chemokine Response Profiles during B Cell Differentiation and Maturation J. Exp. Med., April 17, 2000; 191(8): 1303 - 1318. [Abstract] [Full Text] [PDF]
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A. Iwasaki and B. L. Kelsall Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3{alpha}, Mip-3{beta}, and Secondary Lymphoid Organ Chemokine J. Exp. Med., April 17, 2000; 191(8): 1381 - 1394. [Abstract] [Full Text] [PDF]
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 P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]
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C.-R. Yu, K. W. C. Peden, M. B. Zaitseva, H. Golding, and J. M. Farber CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand J. Immunol., February 1, 2000; 164(3): 1293 - 1305. [Abstract] [Full Text] [PDF]
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A.-S. Charbonnier, N. Kohrgruber, E. Kriehuber, G. Stingl, A. Rot, and D. Maurer Macrophage Inflammatory Protein 3{alpha} Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells J. Exp. Med., December 20, 1999; 190(12): 1755 - 1768. [Abstract] [Full Text] [PDF]
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B. A. Zabel, W. W. Agace, J. J. Campbell, H. M. Heath, D. Parent, A. I. Roberts, E. C. Ebert, N. Kassam, S. Qin, M. Zovko, et al. Human G Protein-Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine-Mediated Chemotaxis J. Exp. Med., November 1, 1999; 190(9): 1241 - 1256. [Abstract] [Full Text] [PDF]
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J. M. Perez-Canadillas, A. Zaballos, J. Gutierrez, R. Varona, F. Roncal, J. P. Albar, G. Marquez, and M. Bruix NMR Solution Structure of Murine CCL20/MIP-3alpha , a Chemokine That Specifically Chemoattracts Immature Dendritic Cells and Lymphocytes through Its Highly Specific Interaction with the beta -Chemokine Receptor CCR6 J. Biol. Chem., July 20, 2001; 276(30): 28372 - 28379. [Abstract] [Full Text] [PDF]
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