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The Journal of Immunology, 1999, 162: 161-167.
Copyright © 1999 by The American Association of Immunologists

Diverse TCRs Recognize Murine CD11

Samuel M. Behar2,*, T. A. Podrebarac*, C. J. Roy*, C. R. Wang{dagger} and M. B. Brenner*

* Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115; and {dagger} Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637

Human and murine T cells that specifically recognize CD1d and produce IL-4 and IFN-{gamma} play a role in immunoregulation and tumor rejection. In the mouse, most CD1d1-reactive T cells described express an invariant V{alpha}14-J{alpha}281 TCR associated with TCR ß-chains of limited diversity. Similarly, human CD1d-reactive T cells express a highly restricted TCR repertoire. Here we report the unexpected result that in mice immunized with CD1d1-bearing transfectant cells, a diverse repertoire of TCRs was expressed by CD1d1-reactive T cell clones isolated by limiting dilution without preselection for NK1 expression. Only 3 of 10 CD1d1-reactive T cell clones expressed the invariant V{alpha}14-J{alpha}281 TCR{alpha} rearrangement. T cells expressing V{alpha}10, -11, -15, and -17, and having non-germline-encoded nucleotides resulting in diverse V-J junctions were identified. Like CD1d1-reactive T cells expressing the invariant V{alpha}14-J{alpha}281 TCR {alpha}-chain, CD1d1-reactive clones with diverse TCRs produced both Type 1 (IFN-{gamma}) and Type 2 (IL-4, IL-10) cytokines. This establishes the existence of significant diversity in the TCRs directly reactive to the CD1d1 protein. Our findings reveal that CD1d interacts with a broad array of TCRs, suggesting substantial redundancy and flexibility of the immune system in providing T cells serving the role(s) mediated by CD1d reactivity.




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