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Departments of Medicine and Microbiology, Dartmouth Medical School, Hanover NH 03755; and
Laboratoire Associé Institut National de la Recherche Agronomique d’Immunologie Parasitaire, Faculté de Pharmacie, Tours, France
Intraepithelial lymphocytes (IEL) of the intestine represent an
important barrier in the prevention of infection against orally
acquired pathogens. Adoptive transfer of Ag-primed IEL into a naive
host can protect against challenge. Using a murine model, we
demonstrate in two genetically distinct mouse strains (C57BL/6 and
CBA/J) that protective IEL can be isolated at specific times after oral
infection with cysts containing bradyzoites. Adoptive transfer of IEL
obtained from the intestine of infected mice at these specific times
can provide long term protection, as determined by mortality and cyst
number against challenge. The protective IEL appear to be
CD8+, TCR-
/ß and are at least partially dependent upon
the presence of TCR-
/
T cells in the host. Endogenous production
of the pivotal cytokine, IFN-, is essential for host immunity. These
findings demonstrate that gut-derived IEL represent a potentially
important mechanism to provide long term immunity to the
host.
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