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*
Division of Cancer Research, Department of Pathology, University Hospital Zürich, Zürich, Switzerland; and
Basel Institute for Immunology, Basel, Switzerland
Expression of the T1 gene, also known as ST2, DER4,
and Fit-1, has been shown to be associated with cell proliferation. It
gives rise to two different mRNAs that encode a receptor-like protein
and a soluble molecule representing the ectodomain of the receptor
form. Although T1 is a member of the IL-1R family, its biologic
function is currently unknown. In this study, we have analyzed the
expression of the T1 surface Ag in murine hemopoietic organs. Mast
cells (MCs) were shown to be the only identifiable cell lineage that
expressed T1 at high levels. T1 expression was found on cultured bone
marrow-derived immature MCs. Similarly, freshly isolated connective
tissue-type MCs from the i.p. cavity were also shown to express high
levels of T1. Interestingly, the earliest detectable committed MC
precursor isolated from fetal blood (FB) at day 15.5 of gestation, but
not circulating hemopoietic stem cells in FB, also expresses high level
of T1. Since FB promastocytes lack expression of the high affinity IgE
receptor (Fc
RI), T1 expression precedes expression of FcRI in MC
ontogeny. The finding that the T1 Ag is selectively expressed at
several stages during development of the MC lineage suggests that this
cell surface molecule, in combination with the well-established markers
c-Kit and FcRI, should be valuable for studying the MC
lineage.
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