| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Containing Complexes Play a Predominant Role in Induction of IFN-
-Inducible Protein, 10 kDa (IP-10) by IFN- Alone or in Synergy with TNF-1
*
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, and
Neurology Department, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195
Human IFN-
-inducible protein, 10 kDa (hIP-10) and murine IP-10
(mIP-10) genes are induced by IFN- alone, and synergistically
induced by TNF-
and IFN-. Upstream regions of the human and
murine genes contain conserved regulatory motifs, including an
IFN-stimulated response element (ISRE), which governs response of the
mIP-10 gene to IFN-. Trans-acting factors mediating the
IFN- response via ISRE remain incompletely defined. We examined
ISRE-binding factors in the regulation of the hIP-10 gene. The
requirement of p48 for hIP-10 induction by IFN-, with or without
TNF-, was demonstrated using p48-deficient U2A cells. An hIP-10
promoter-reporter mutant (mISRE3) that was relatively deficient for
binding a related factor, IFN regulatory factor-1 (IRF-1) but competent
for binding p48, was induced as well as the wild-type hIP-10 promoter,
supporting the interpretation that p48 played a necessary and
sufficient role in hIP-10 transcription. Genomic in vivo footprinting
revealed IFN-/TNF--inducible binding at the ISRE consistent with
the presence of p48 and associated factors, but not with IRF-1.
Induction of hIP-10 by TNF-/IFN- also required NF
B binding
sites, which were protected in vivo and bound p65 homodimeric NFB in
vitro. These results documented the essential role of p48 (complexed
with STAT-1) for induction and sustained transcription of the IP-10
gene, strongly suggesting that IRF-1 is not required for IP-10
induction by these inflammatory cytokines.
This article has been cited by other articles:
|
|
 |
|
  A. L. Shaffer, N.C. T. Emre, P. B. Romesser, and L. M. Staudt IRF4: Immunity. Malignancy! Therapy? Clin. Cancer Res., May 1, 2009; 15(9): 2954 - 2961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Zaheer, R. Koetzler, N. S. Holden, S. Wiehler, and D. Proud Selective Transcriptional Down-Regulation of Human Rhinovirus-Induced Production of CXCL10 from Airway Epithelial Cells via the MEK1 Pathway J. Immunol., April 15, 2009; 182(8): 4854 - 4864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Lou, X.-R. Pan, P.-M. Jia, D. Li, S. Xiao, Z.-L. Zhang, S.-J. Chen, Z. Chen, and J.-H. Tong IFR-9/STAT2 Functional Interaction Drives Retinoic Acid-Induced Gene G Expression Independently of STAT1 Cancer Res., April 15, 2009; 69(8): 3673 - 3680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Park, M. A. Hughes, M. Burdick, R. M. Strieter, and B. Mehrad Early NK Cell-Derived IFN-{gamma} Is Essential to Host Defense in Neutropenic Invasive Aspergillosis J. Immunol., April 1, 2009; 182(7): 4306 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Lee, P. Wang, M. G. Kattah, S. Youssef, L. Steinman, K. DeFea, and D. S. Straus Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells J. Immunol., November 1, 2008; 181(9): 6536 - 6545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jayakumar, M. J. Donovan, V. Tripathi, M. Ramalho-Ortigao, and M. A. McDowell Leishmania major Infection Activates NF-{kappa}B and Interferon Regulatory Factors 1 and 8 in Human Dendritic Cells Infect. Immun., May 1, 2008; 76(5): 2138 - 2148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Randall and S. Goodbourn Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures J. Gen. Virol., January 1, 2008; 89(1): 1 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Datta, O. Dormond, A. Basu, D. M. Briscoe, and S. Pal Heme oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1222 - F1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Dhillon, F. Peng, R. M. Ransohoff, and S. Buch PDGF Synergistically Enhances IFN-{gamma}-Induced Expression of CXCL10 in Blood-Derived Macrophages: Implications for HIV Dementia J. Immunol., September 1, 2007; 179(5): 2722 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kanda and S. Watanabe Prolactin Enhances Interferon-{gamma}-Induced Production of CXC Ligand 9 (CXCL9), CXCL10, and CXCL11 in Human Keratinocytes Endocrinology, May 1, 2007; 148(5): 2317 - 2325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Pietila, V. Veckman, A. Lehtonen, R. Lin, J. Hiscott, and I. Julkunen Multiple NF-{kappa}B and IFN Regulatory Factor Family Transcription Factors Regulate CCL19 Gene Expression in Human Monocyte-Derived Dendritic Cells J. Immunol., January 1, 2007; 178(1): 253 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Datta, J. A. Flaxenburg, S. Laxmanan, C. Geehan, M. Grimm, A. M. Waaga-Gasser, D. M. Briscoe, and S. Pal Ras-induced Modulation of CXCL10 and Its Receptor Splice Variant CXCR3-B in MDA-MB-435 and MCF-7 Cells: Relevance for the Development of Human Breast Cancer Cancer Res., October 1, 2006; 66(19): 9509 - 9518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nozell, T. Laver, K. Patel, and E. N. Benveniste Mechanism of IFN-beta-Mediated Inhibition of IL-8 Gene Expression in Astroglioma Cells J. Immunol., July 15, 2006; 177(2): 822 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Punturieri, P. Copper, T. Polak, P. J. Christensen, and J. L. Curtis Conserved Nontypeable Haemophilus influenzae-Derived TLR2-Binding Lipopeptides Synergize with IFN-beta to Increase Cytokine Production by Resident Murine and Human Alveolar Macrophages J. Immunol., July 1, 2006; 177(1): 673 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Medoff, J. C. Wain, E. Seung, R. Jackobek, T. K. Means, L. C. Ginns, J. M. Farber, and A. D. Luster CXCR3 and Its Ligands in a Murine Model of Obliterative Bronchiolitis: Regulation and Function. J. Immunol., June 1, 2006; 176(11): 7087 - 7095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Boulday, Z. Haskova, M. E. J. Reinders, S. Pal, and D. M. Briscoe Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-{gamma}-Inducible Protein of 10 kDa In Vitro and In Vivo. J. Immunol., March 1, 2006; 176(5): 3098 - 3107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Podgoreanu, G. A. Michelotti, Y. Sato, M. P. Smith, S. Lin, R. W. Morris, H. P. Grocott, J. P. Mathew, and D. A. Schwinn Differential cardiac gene expression during cardiopulmonary bypass: Ischemia-independent upregulation of proinflammatory genes J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 330 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. L. Spurrell, S. Wiehler, R. S. Zaheer, S. P. Sanders, and D. Proud Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L85 - L95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Md Sheikh, H. Ochi, A. Manabe, and J. Masuda Lysophosphatidylcholine posttranscriptionally inhibits interferon-{gamma}-induced IP-10, Mig and I-Tac expression in endothelial cells Cardiovasc Res, January 1, 2005; 65(1): 263 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Raju, Y. Hoshino, K. Kuwabara, I. Belitskaya, S. Prabhakar, A. Canova, J. A. Gold, R. Condos, R. I. Pine, S. Brown, et al. Aerosolized Gamma Interferon (IFN-{gamma}) Induces Expression of the Genes Encoding the IFN-{gamma}-Inducible 10-Kilodalton Protein but Not Inducible Nitric Oxide Synthase in the Lung during Tuberculosis Infect. Immun., March 1, 2004; 72(3): 1275 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramesh, A. M. Mhashilkar, F. Tanaka, Y. Saito, C. D. Branch, K. Sieger, J. B. Mumm, A. L. Stewart, A. Boquio, L. Dumoutier, et al. Melanoma Differentiation-associated Gene 7/Interleukin (IL)-24 Is a Novel Ligand That Regulates Angiogenesis via the IL-22 Receptor Cancer Res., August 15, 2003; 63(16): 5105 - 5113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prabhakar, Y. Qiao, Y. Hoshino, M. Weiden, A. Canova, E. Giacomini, E. Coccia, and R. Pine Inhibition of Response to Alpha Interferon by Mycobacterium tuberculosis Infect. Immun., May 1, 2003; 71(5): 2487 - 2497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Shanmugam, M. A. Reddy, M. Guha, and R. Natarajan High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells Diabetes, May 1, 2003; 52(5): 1256 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C.-J. Cheeran, S. Hu, W. S. Sheng, P. K. Peterson, and J. R. Lokensgard CXCL10 Production from Cytomegalovirus-Stimulated Microglia Is Regulated by both Human and Viral Interleukin-10 J. Virol., April 15, 2003; 77(8): 4502 - 4515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Kraus, J. F. Lau, J.-P. Parisien, and C. M. Horvath A Hybrid IRF9-STAT2 Protein Recapitulates Interferon-stimulated Gene Expression and Antiviral Response J. Biol. Chem., April 4, 2003; 278(15): 13033 - 13038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nagaoka, A. Sakai, H. Nojima, Y. Suda, Y. Yokomizo, K. Imakawa, S. Sakai, and R. K. Christenson A Chemokine, Interferon (IFN)-{gamma}-Inducible Protein 10 kDa, Is Stimulated by IFN-{tau} and Recruits Immune Cells in the Ovine Endometrium Biol Reprod, April 1, 2003; 68(4): 1413 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Barnes, M. J. Kellum, A. E. Field, and P. M. Pitha Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes Mol. Cell. Biol., August 15, 2002; 22(16): 5721 - 5740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Federici, M. L. Giustizieri, C. Scarponi, G. Girolomoni, and C. Albanesi Impaired IFN-{gamma}-Dependent Inflammatory Responses in Human Keratinocytes Overexpressing the Suppressor of Cytokine Signaling 1 J. Immunol., July 1, 2002; 169(1): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Afrouzian, V. Ramassar, J. Urmson, L.-F. Zhu, and P. F. Halloran Transcription Factor IRF-1 in Kidney Transplants Mediates Resistance to Graft Necrosis during Rejection J. Am. Soc. Nephrol., May 1, 2002; 13(5): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Guo, T. Yang, X. Liu, S. Lu, J. Wen, J. E. Durbin, Y. Liu, and P. Zheng Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-{gamma}-mediated activation of the transcription initiator Int. Immunol., February 1, 2002; 14(2): 189 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Romagnani, E. Lazzeri, L. Lasagni, C. Mavilia, C. Beltrame, M. Francalanci, M. Rotondi, F. Annunziato, L. Maurenzig, L. Cosmi, et al. IP-10 and Mig Production by Glomerular Cells in Human Proliferative Glomerulonephritis and Regulation by Nitric Oxide J. Am. Soc. Nephrol., January 1, 2002; 13(1): 53 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. C. Asensio, J. Maier, R. Milner, K. Boztug, C. Kincaid, M. Moulard, C. Phillipson, K. Lindsley, T. Krucker, H. S. Fox, et al. Interferon-Independent, Human Immunodeficiency Virus Type 1 gp120-Mediated Induction of CXCL10/IP-10 Gene Expression by Astrocytes In Vivo and In Vitro J. Virol., August 1, 2001; 75(15): 7067 - 7077. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. Sundstrom, L. K. McMullan, C. F. Spiropoulou, W. C. Hooper, A. A. Ansari, C. J. Peters, and P. E. Rollin Hantavirus Infection Induces the Expression of RANTES and IP-10 without Causing Increased Permeability in Human Lung Microvascular Endothelial Cells J. Virol., July 1, 2001; 75(13): 6070 - 6085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-H. L. ZHOU, Y. HAN, T. WEI, S. ARAS, P. CHATURVEDI, S. TYLER, M. R. S. RANI, and R. M. RANSOHOFF Regulation of monocyte chemoattractant protein (MCP)-1 transcription by interferon-gamma (IFN-{gamma}) in human astrocytoma cells: postinduction refractory state of the gene, governed by its upstream elements FASEB J, February 1, 2001; 15(2): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Lau, J.-P. Parisien, and C. M. Horvath Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors PNAS, June 20, 2000; 97(13): 7278 - 7283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Marx, F. Mach, A. Sauty, J. H. Leung, M. N. Sarafi, R. M. Ransohoff, P. Libby, J. Plutzky, and A. D. Luster Peroxisome Proliferator-Activated Receptor-{gamma} Activators Inhibit IFN-{gamma}-Induced Expression of the T Cell-Active CXC Chemokines IP-10, Mig, and I-TAC in Human Endothelial Cells J. Immunol., June 15, 2000; 164(12): 6503 - 6508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. S. Rani, A. R. Asthagiri, A. Singh, N. Sizemore, S. S. Sathe, X. Li, J. D. DiDonato, G. R. Stark, and R. M. Ransohoff A Role for NF-kappa B in the Induction of beta -R1 by Interferon-beta J. Biol. Chem., November 21, 2001; 276(48): 44365 - 44368. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
