| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan;
Research Institute, Osaka Maternal and Child Health Center, Izumi, Osaka, Japan;
Department of Environmental Medicine, Osaka University Medical School, Osaka, Japan; and
§
Osaka University, Suita, Osaka, Japan
Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice genetically deficient in the Stat3 gene has revealed its important role in the early embryogenesis. To assess the function of Stat3 in adult tissues, we disrupted the Stat3 gene specifically in T cells by conditional gene targeting using Cre-loxP system. In Stat3-deficient T cells, IL-6-induced proliferation was severely impaired. IL-6 did not enhance cell cycle progression, but prevented apoptosis of normal T cells. In contrast, IL-6 did not prevent apoptosis of Stat3-deficient T cells. Antiapoptotic protein, Bcl-2, was normally up-regulated in response to IL-6 even in Stat3-deficient T cells. These results demonstrate that Stat3 activation is involved in IL-6-dependent T cell proliferation through prevention of apoptosis independently of Bcl-2.
This article has been cited by other articles:
|
|
 |
|
  G. Pickert, C. Neufert, M. Leppkes, Y. Zheng, N. Wittkopf, M. Warntjen, H.-A. Lehr, S. Hirth, B. Weigmann, S. Wirtz, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing J. Exp. Med., July 6, 2009; 206(7): 1465 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shiraishi, H. Yoshida, K. Saeki, Y. Miura, S. Watanabe, T. Ishizaki, M. Hashimoto, G. Takaesu, T. Kobayashi, and A. Yoshimura Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells Int. Immunol., September 1, 2008; 20(9): 1219 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Herrmann, T. Imura, B. Song, J. Qi, Y. Ao, T. K. Nguyen, R. A. Korsak, K. Takeda, S. Akira, and M. V. Sofroniew STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury J. Neurosci., July 9, 2008; 28(28): 7231 - 7243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gagnon, S. Ramanathan, C. Leblanc, A. Cloutier, P. P. McDonald, and S. Ilangumaran IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes J. Immunol., June 15, 2008; 180(12): 7958 - 7968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kida, M. L. Mucenski, A. R. Thitoff, T. D. Le Cras, K.-S. Park, M. Ikegami, W. Muller, and J. A. Whitsett GP130-STAT3 Regulates Epithelial Cell Migration and Is Required for Repair of the Bronchiolar Epithelium Am. J. Pathol., June 1, 2008; 172(6): 1542 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Matsuzaki, V. Besnard, J. C. Clark, Y. Xu, S. E. Wert, M. Ikegami, and J. A. Whitsett STAT3 Regulates ABCA3 Expression and Influences Lamellar Body Formation in Alveolar Type II Cells Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 551 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Ozog, G. Modha, J. Church, R. Reilly, and C. C. Naus Co-administration of Ciliary Neurotrophic Factor with Its Soluble Receptor Protects against Neuronal Death and Enhances Neurite Outgrowth J. Biol. Chem., March 7, 2008; 283(10): 6546 - 6560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Piper, E. K. Unger, M. G. Myers Jr., and A. W. Xu Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons Mol. Endocrinol., March 1, 2008; 22(3): 751 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kennedy Norton, B. Barnstein, J. Brenzovich, D. P. Bailey, M. Kashyap, K. Speiran, J. Ford, D. Conrad, S. Watowich, M. R. Moralle, et al. IL-10 Suppresses Mast Cell IgE Receptor Expression and Signaling In Vitro and In Vivo J. Immunol., March 1, 2008; 180(5): 2848 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Owaki, M. Asakawa, N. Morishima, I. Mizoguchi, F. Fukai, K. Takeda, J. Mizuguchi, and T. Yoshimoto STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production J. Immunol., March 1, 2008; 180(5): 2903 - 2911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Huber, V. Steinwald, A. Guralnik, A. Brustle, P. Kleemann, C. Rosenplanter, T. Decker, and M. Lohoff IL-27 inhibits the development of regulatory T cells via STAT3 Int. Immunol., February 1, 2008; 20(2): 223 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Bong, H.-S. Lee, L. Carim-Todd, K. Mood, T. G. Nishanian, L. Tessarollo, and I. O. Daar ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3 PNAS, October 30, 2007; 104(44): 17305 - 17310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brender, G. M. Tannahill, B. J. Jenkins, J. Fletcher, R. Columbus, C. J. M. Saris, M. Ernst, N. A. Nicola, D. J. Hilton, W. S. Alexander, et al. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27 Blood, October 1, 2007; 110(7): 2528 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, H. Du, Y. Qin, J. Roberts, O. W. Cummings, and C. Yan Activation of the Signal Transducers and Activators of the Transcription 3 Pathway in Alveolar Epithelial Cells Induces Inflammation and Adenocarcinomas in Mouse Lung Cancer Res., September 15, 2007; 67(18): 8494 - 8503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Luty, D. Rodeberg, J. Parness, and Y. M. Vyas Antiparallel Segregation of Notch Components in the Immunological Synapse Directs Reciprocal Signaling in Allogeneic Th:DC Conjugates J. Immunol., July 15, 2007; 179(2): 819 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nishihara, H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Tsuji, H. Aono, K. Ishihara, E. Huseby, U. A. K. Betz, et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state Int. Immunol., June 1, 2007; 19(6): 695 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Finotto, T. Eigenbrod, R. Karwot, I. Boross, A. Doganci, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells Int. Immunol., June 1, 2007; 19(6): 685 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Simeone-Penney, M. Severgnini, P. Tu, R. J. Homer, T. J. Mariani, L. Cohn, and A. R. Simon Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma J. Immunol., May 15, 2007; 178(10): 6191 - 6199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zeng, R. Spolski, E. Casas, W. Zhu, D. E. Levy, and W. J. Leonard The molecular basis of IL-21-mediated proliferation Blood, May 15, 2007; 109(10): 4135 - 4142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhou, L. McPherson, D. Feng, A. Song, C. Dong, S.-C. Lyu, L. Zhou, X. Shi, Y.-T. Ahn, D. Wang, et al. Kruppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo J. Immunol., May 1, 2007; 178(9): 5496 - 5504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mathur, H.-C. Chang, D. G. Zisoulis, G. L. Stritesky, Q. Yu, J. T. O'Malley, R. Kapur, D. E. Levy, G. S. Kansas, and M. H. Kaplan Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells J. Immunol., April 15, 2007; 178(8): 4901 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. O. Yang, A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells J. Biol. Chem., March 30, 2007; 282(13): 9358 - 9363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cao, T. L. Tal, L. M. Graves, I. Gilmour, W. Linak, W. Reed, P. A. Bromberg, and J. M. Samet Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L422 - L429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Xu, L. Ste-Marie, C. B. Kaelin, and G. S. Barsh Inactivation of Signal Transducer and Activator of Transcription 3 in Proopiomelanocortin (Pomc) Neurons Causes Decreased Pomc Expression, Mild Obesity, and Defects in Compensatory Refeeding Endocrinology, January 1, 2007; 148(1): 72 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Panopoulos, L. Zhang, J. W. Snow, D. M. Jones, A. M. Smith, K. C. El Kasmi, F. Liu, M. A. Goldsmith, D. C. Link, P. J. Murray, et al. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils Blood, December 1, 2006; 108(12): 3682 - 3690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. S. Nagy, H. Rui, S. M. Stepkowski, J. Karras, and R. A. Kirken A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor J. Immunol., October 15, 2006; 177(8): 5032 - 5040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshimura, A. Takeda, S. Hamano, Y. Miyazaki, I. Kinjyo, T. Ishibashi, A. Yoshimura, and H. Yoshida Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism J. Immunol., October 15, 2006; 177(8): 5377 - 5385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Kaelin, L. Gong, A. W. Xu, F. Yao, K. Hockman, G. J. Morton, M. W. Schwartz, G. S. Barsh, and R. G. MacKenzie Signal Transducer and Activator of Transcription (Stat) Binding Sites But Not Stat3 Are Required for Fasting-Induced Transcription of Agouti-Related Protein Messenger Ribonucleic Acid Mol. Endocrinol., October 1, 2006; 20(10): 2591 - 2602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Matsuzaki, Y. Xu, M. Ikegami, V. Besnard, K.-S. Park, W. M. Hull, S. E. Wert, and J. A. Whitsett Stat3 Is Required for Cytoprotection of the Respiratory Epithelium during Adenoviral Infection J. Immunol., July 1, 2006; 177(1): 527 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshimatsu, D. Kawaguchi, K. Oishi, K. Takeda, S. Akira, N. Masuyama, and Y. Gotoh Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex Development, July 1, 2006; 133(13): 2553 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Miyatsuka, H. Kaneto, T. Shiraiwa, T.-a. Matsuoka, K. Yamamoto, K. Kato, Y. Nakamura, S. Akira, K. Takeda, Y. Kajimoto, et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation Genes & Dev., June 1, 2006; 20(11): 1435 - 1440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tedgui and Z. Mallat Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways Physiol Rev, April 1, 2006; 86(2): 515 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Owaki, M. Asakawa, S. Kamiya, K. Takeda, F. Fukai, J. Mizuguchi, and T. Yoshimoto IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3. J. Immunol., March 1, 2006; 176(5): 2773 - 2780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gartsbein, A. Alt, K. Hashimoto, K. Nakajima, T. Kuroki, and T. Tennenbaum The role of protein kinase C {delta} activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation J. Cell Sci., February 1, 2006; 119(3): 470 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Fornek, L. T. Tygrett, T. J. Waldschmidt, V. Poli, R. C. Rickert, and G. S. Kansas Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells Blood, February 1, 2006; 107(3): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Villarino, J. S. Stumhofer, C. J. M. Saris, R. A. Kastelein, F. J. de Sauvage, and C. A. Hunter IL-27 Limits IL-2 Production during Th1 Differentiation J. Immunol., January 1, 2006; 176(1): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mechoulam and E. A. Pierce Expression and Activation of STAT3 in Ischemia-Induced Retinopathy Invest. Ophthalmol. Vis. Sci., December 1, 2005; 46(12): 4409 - 4416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ikegami, J. A. Whitsett, P. C. Martis, and T. E. Weaver Reversibility of lung inflammation caused by SP-B deficiency Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L962 - L970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Selvaraj, D. Bunick, C. Finnigan-Bunick, R. W. Johnson, H. Wang, L. Liu, and P. S. Cooke Gene Expression Profiling of 17{beta}-Estradiol and Genistein Effects on Mouse Thymus Toxicol. Sci., September 1, 2005; 87(1): 97 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kato, A. Iwama, Y. Tadokoro, K. Shimoda, M. Minoguchi, S. Akira, M. Tanaka, A. Miyajima, T. Kitamura, and H. Nakauchi Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis J. Exp. Med., July 5, 2005; 202(1): 169 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. McLoughlin, B. J. Jenkins, D. Grail, A. S. Williams, C. A. Fielding, C. R. Parker, M. Ernst, N. Topley, and S. A. Jones IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation PNAS, July 5, 2005; 102(27): 9589 - 9594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis Blood, May 1, 2005; 105(9): 3512 - 3520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matarese, S. Moschos, and C. S. Mantzoros Leptin in Immunology J. Immunol., March 15, 2005; 174(6): 3137 - 3142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Butcher, L. Kim, A. D. Panopoulos, S. S. Watowich, P. J. Murray, and E. Y. Denkers Cutting Edge: IL-10-Independent STAT3 Activation by Toxoplasma gondii Mediates Suppression of IL-12 and TNF-{alpha} in Host Macrophages J. Immunol., March 15, 2005; 174(6): 3148 - 3152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, J. Ochando, A. Yopp, J. S. Bromberg, and Y. Ding IL-6 Plays a Unique Role in Initiating c-Maf Expression during Early Stage of CD4 T Cell Activation J. Immunol., March 1, 2005; 174(5): 2720 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ahr, M. Denizot, V. Robert-Hebmann, A. Brelot, and M. Biard-Piechaczyk Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation J. Biol. Chem., February 25, 2005; 280(8): 6692 - 6700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Schick, E. J. Oakeley, N. E. Hynes, and A. Badache TEL/ETV6 Is a Signal Transducer and Activator of Transcription 3 (Stat3)-induced Repressor of Stat3 Activity J. Biol. Chem., September 10, 2004; 279(37): 38787 - 38796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Smith, N. Suleman, L. Lacerda, L. H. Opie, S. Akira, K. R. Chien, and M. N. Sack Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning Cardiovasc Res, September 1, 2004; 63(4): 611 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sun, Z. Tian, S. Kulkarni, and B. Gao IL-6 Prevents T Cell-Mediated Hepatitis via Inhibition of NKT Cells in CD4+ T Cell- and STAT3-Dependent Manners J. Immunol., May 1, 2004; 172(9): 5648 - 5655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume Interferon-{gamma}: an overview of signals, mechanisms and functions J. Leukoc. Biol., February 1, 2004; 75(2): 163 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Cui, L. Huang, F. Elefteriou, G. Yang, J. M. Shelton, J. E. Giles, O. K. Oz, T. Pourbahrami, C. Y. H. Lu, J. A. Richardson, et al. Essential Role of STAT3 in Body Weight and Glucose Homeostasis Mol. Cell. Biol., January 1, 2004; 24(1): 258 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shen, K. Schlessinger, X. Zhu, E. Meffre, F. Quimby, D. E. Levy, and J. E. Darnell Jr. Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation Mol. Cell. Biol., January 1, 2004; 24(1): 407 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kano, M. J. Wolfgang, Q. Gao, J. Jacoby, G.-X. Chai, W. Hansen, Y. Iwamoto, J. S. Pober, R. A. Flavell, and X.-Y. Fu Endothelial Cells Require STAT3 for Protection against Endotoxin-induced Inf lammation J. Exp. Med., November 17, 2003; 198(10): 1517 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Percario, E. Olivetta, G. Fiorucci, G. Mangino, S. Peretti, G. Romeo, E. Affabris, and M. Federico Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery J. Leukoc. Biol., November 1, 2003; 74(5): 821 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tomita, H.-B. Jiang, T. Ueno, S. Takagi, K. Tohi, S.-i. Maekawa, A. Miyatake, A. Furukawa, F. J. Gonzalez, J. Takeda, et al. T Cell-Specific Disruption of Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Gene Causes Resistance to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Thymic Involution J. Immunol., October 15, 2003; 171(8): 4113 - 4120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Waxman, K. Mahboubi, R. G. Knickelbein, L. L. Mantell, N. Manzo, J. S. Pober, and J. A. Elias Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H2O2-Induced Cell Death Am. J. Respir. Cell Mol. Biol., October 1, 2003; 29(4): 513 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Bharti, N. Donato, and B. B. Aggarwal Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells J. Immunol., October 1, 2003; 171(7): 3863 - 3871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Shillingford, K. Miyoshi, G. W. Robinson, B. Bierie, Y. Cao, M. Karin, and L. Hennighausen Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions J. Histochem. Cytochem., May 1, 2003; 51(5): 555 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler Signal transducer and activator of transcription proteins in leukemias Blood, April 15, 2003; 101(8): 2940 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Welte, S. S. M. Zhang, T. Wang, Z. Zhang, D. G. T. Hesslein, Z. Yin, A. Kano, Y. Iwamoto, E. Li, J. E. Craft, et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity PNAS, February 18, 2003; 100(4): 1879 - 1884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sanjo, K. Takeda, T. Tsujimura, J. Ninomiya-Tsuji, K. Matsumoto, and S. Akira TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling Mol. Cell. Biol., February 15, 2003; 23(4): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamada, N. Ishii, H. Asao, K. Murata, C. Kanazawa, H. Sasaki, and K. Sugamura Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival Mol. Cell. Biol., December 15, 2002; 22(24): 8648 - 8658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Scott, C. J. Godshall, and W. G. Cheadle Jaks, STATs, Cytokines, and Sepsis Clin. Vaccine Immunol., November 1, 2002; 9(6): 1153 - 1159. [Full Text] [PDF]
|
|
|
|
|
|
T. Atsumi, K. Ishihara, D. Kamimura, H. Ikushima, T. Ohtani, S. Hirota, H. Kobayashi, S.-J. Park, Y. Saeki, Y. Kitamura, et al. A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis J. Exp. Med., October 7, 2002; 196(7): 979 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Humphreys, B. Bierie, L. Zhao, R. Raz, D. Levy, and L. Hennighausen Deletion of Stat3 Blocks Mammary Gland Involution and Extends Functional Competence of the Secretory Epithelium in the Absence of Lactogenic Stimuli Endocrinology, September 1, 2002; 143(9): 3641 - 3650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Li, X. Liang, C. Kellendonk, V. Poli, and R. Taub STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration J. Biol. Chem., August 2, 2002; 277(32): 28411 - 28417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shen and M. H. Kaplan The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27Kip1 J. Immunol., July 15, 2002; 169(2): 714 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sun and B. M. Steinberg PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells J. Gen. Virol., June 1, 2002; 83(7): 1651 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kirito, M. Osawa, H. Morita, R. Shimizu, M. Yamamoto, A. Oda, H. Fujita, M. Tanaka, K. Nakajima, Y. Miura, et al. A functional role of Stat3 in in vivo megakaryopoiesis Blood, May 1, 2002; 99(9): 3220 - 3227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Vancurova, R. Wu, V. Miskolci, and S. Sun Increased p50/p50 NF-{kappa}B Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue J. Virol., February 1, 2002; 76(3): 1533 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Narimatsu, H. Maeda, S. Itoh, T. Atsumi, T. Ohtani, K. Nishida, M. Itoh, D. Kamimura, S.-J. Park, K. Mizuno, et al. Tissue-Specific Autoregulation of the stat3 Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells Mol. Cell. Biol., October 1, 2001; 21(19): 6615 - 6625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Ning, J. Li, and R. J. Arceci Signal transducer and activator of transcription 3 activation is required for Asp816 mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells Blood, June 1, 2001; 97(11): 3559 - 3567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Suter, I. R. Hendry, L. Ndjountche, K. Obholz, J. K. Pru, J. S. Davis, and B. R. Rueda Mediators of Interferon {{gamma}}-Initiated Signaling in Bovine Luteal Cells Biol Reprod, May 1, 2001; 64(5): 1481 - 1486. [Abstract] [Full Text]
|
|
|
|
|
|
T. Alonzi, D. Maritano, B. Gorgoni, G. Rizzuto, C. Libert, and V. Poli Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver Mol. Cell. Biol., March 1, 2001; 21(5): 1621 - 1632. [Abstract] [Full Text]
|
|
|
|
|
|
A. Suzuki, T. Hanada, K. Mitsuyama, T. Yoshida, S. Kamizono, T. Hoshino, M. Kubo, A. Yamashita, M. Okabe, K. Takeda, et al. Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation J. Exp. Med., February 19, 2001; 193(4): 471 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shen, G. Devgan, J. E. Darnell Jr., and J. F. Bromberg Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1 PNAS, February 1, 2001; (2001) 41588198. [Abstract] [Full Text]
|
|
|
|
|
|
J. Domen and I. L. Weissman Hematopoietic Stem Cells Need Two Signals to Prevent Apoptosis; Bcl-2 Can Provide One of These, Kitl/C-KIT Signaling the Other J. Exp. Med., December 18, 2000; 192(12): 1707 - 1718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. GALLUCCI, P. P. SIMEONOVA, J. M. MATHESON, C. KOMMINENI, J. L. GURIEL, T. SUGAWARA, and M. I. LUSTER Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice FASEB J, December 1, 2000; 14(15): 2525 - 2531. [Abstract] [Full Text]
|
|
|
|
|
|
A. S. K. de Hooge, F. A. J. van de Loo, O. J. Arntz, and W. B. van den Berg Involvement of IL-6, Apart from Its Role in Immunity, in Mediating a Chronic Response during Experimental Arthritis Am. J. Pathol., December 1, 2000; 157(6): 2081 - 2091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Ahmed and L. B. Ivashkiv Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways J. Immunol., November 1, 2000; 165(9): 5227 - 5237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Fantuzzi and R. Faggioni Leptin in the regulation of immunity, inflammation, and hematopoiesis J. Leukoc. Biol., October 1, 2000; 68(4): 437 - 446. [Abstract] [Full Text]
|
|
|
|
|
|
C. Kawamura, M. Kizaki, K. Yamato, H. Uchida, Y. Fukuchi, Y. Hattori, T. Koseki, T. Nishihara, and Y. Ikeda Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3 Blood, September 15, 2000; 96(6): 2005 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, T. Naka, R. Nakagawa, Y. Kawazoe, Y. Morita, A. Tateishi, K. Okumura, M. Narazaki, and T. Kishimoto Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice J. Immunol., August 15, 2000; 165(4): 1799 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hess, H. Smola, U. Sandaradura de Silva, D. Hadaschik, D. Kube, S. E. Baldus, U. Flucke, and H. Pfister Loss of IL-6 Receptor Expression in Cervical Carcinoma Cells Inhibits Autocrine IL-6 Stimulation: Abrogation of Constitutive Monocyte Chemoattractant Protein-1 Production J. Immunol., August 15, 2000; 165(4): 1939 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K L STREETZ, T LUEDDE, M P MANNS, and C TRAUTWEIN Interleukin 6 and liver regeneration Gut, August 1, 2000; 47(2): 309 - 312. [Full Text] [PDF]
|
|
|
|
|
|
D. DUVAL, B. REINHARDT, C. KEDINGER, and H. BOEUF Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) -dependent embryonic stem cell survival FASEB J, August 1, 2000; 14(11): 1577 - 1584. [Abstract] [Full Text]
|
|
|
|
|
|
L. Rui, D. R. Gunter, J. Herrington, and C. Carter-Su Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bbeta Mol. Cell. Biol., May 1, 2000; 20(9): 3168 - 3177. [Abstract] [Full Text]
|
|
|
|
|
|
E. S. Park, H. Kim, J. M. Suh, S. J. Park, S. H. You, H. K. Chung, K. W. Lee, O-Y. Kwon, B. Y. Cho, Y. K. Kim, et al. Involvement of JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) in the Thyrotropin Signaling Pathway Mol. Endocrinol., May 1, 2000; 14(5): 662 - 670. [Abstract] [Full Text]
|
|
|
|
|
|
H. Daino, I. Matsumura, K. Takada, J. Odajima, H. Tanaka, S. Ueda, H. Shibayama, H. Ikeda, M. Hibi, T. Machii, et al. Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleukin 6-dependent hematopoietic cells Blood, April 15, 2000; 95(8): 2577 - 2585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Grandis, S. D. Drenning, Q. Zeng, S. C. Watkins, M. F. Melhem, S. Endo, D. E. Johnson, L. Huang, Y. He, and J. D. Kim Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo PNAS, April 11, 2000; 97(8): 4227 - 4232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kato, T. Miyazaki, T. Nakamura, and A. Kudo Inducible differentiation and apoptosis of the pre-B cell receptor-positive pre-B cell line Int. Immunol., March 1, 2000; 12(3): 325 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuki, H. Nakajima, Y. Saito, T. Saito, W. J. Leonard, and I. Iwamoto Janus kinase 3 (Jak3) is essential for common cytokine receptor {gamma} chain ({gamma}c)-dependent signaling: comparative analysis of {gamma}c, Jak3, and {gamma}c and Jak3 double-deficient mice Int. Immunol., February 1, 2000; 12(2): 123 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kieslinger, I. Woldman, R. Moriggl, J. Hofmann, J.-C. Marine, J. N. Ihle, H. Beug, and T. Decker Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation Genes & Dev., January 15, 2000; 14(2): 232 - 244. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
