HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Banerjee, A. Articles by Rothman, P. Search for Related Content PubMed PubMed Citation Articles by Banerjee, A. Articles by Rothman, P.

IL-7 Reconstitutes Multiple Aspects of v-Abl-Mediated Signaling¹

Arnob Banerjee^* and Paul Rothman^2,

^* Integrated Program in Cellular, Molecular, and Biophysical Studies and Departments of Medicine and Microbiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032

The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown. Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl. To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined. Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation. IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-x_L that occur upon loss of v-Abl kinase activity. IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-B and RAG gene transcription was unaffected by IL-7. These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.

This article has been cited by other articles:

				J.-L. Chen, A. Limnander, and P. B. Rothman Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene Blood, February 1, 2008; 111(3): 1677 - 1685. [Abstract] [Full Text] [PDF]

				E. A. Jacobsen, O. Ananieva, M. L. Brown, and Y. Chang Growth, Differentiation, and Malignant Transformation of Pre-B Cells Mediated by Inducible Activation of v-Abl Oncogene. J. Immunol., June 1, 2006; 176(11): 6831 - 6838. [Abstract] [Full Text] [PDF]

				L. Gong, I. Unnikrishnan, A. Raghavan, K. Parmar, and N. Rosenberg Active Akt and Functional p53 Modulate Apoptosis in Abelson Virus-Transformed Pre-B Cells J. Virol., February 15, 2004; 78(4): 1636 - 1644. [Abstract] [Full Text] [PDF]

				E. J. Noronha, K. H. Sterling, and K. L. Calame Increased Expression of Bcl-xL and c-Myc Is Associated with Transformation by Abelson Murine Leukemia Virus J. Biol. Chem., December 19, 2003; 278(51): 50915 - 50922. [Abstract] [Full Text] [PDF]

				K. Johnson, C. Angelin-Duclos, S. Park, and K. L. Calame Changes in Histone Acetylation Are Associated with Differences in Accessibility of VH Gene Segments to V-DJ Recombination during B-Cell Ontogeny and Development Mol. Cell. Biol., April 1, 2003; 23(7): 2438 - 2450. [Abstract] [Full Text] [PDF]

				S. Oki, A. Limnander, N. N. Danial, and P. B. Rothman Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells Blood, July 18, 2002; 100(3): 966 - 973. [Abstract] [Full Text] [PDF]

				C. Wuchter, V. Ruppert, M. Schrappe, B. Dorken, W.-D. Ludwig, and L. Karawajew In vitro susceptibility to dexamethasone- and doxorubicin-induced apoptotic cell death in context of maturation stage, responsiveness to interleukin 7, and early cytoreduction in vivo in childhood T-cell acute lymphoblastic leukemia Blood, May 13, 2002; 99(11): 4109 - 4115. [Abstract] [Full Text] [PDF]

				V. Sexl, R. Piekorz, R. Moriggl, J. Rohrer, M. P. Brown, K. D. Bunting, K. Rothammer, M. F. Roussel, and J. N. Ihle Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of Stat5 Blood, September 15, 2000; 96(6): 2277 - 2283. [Abstract] [Full Text] [PDF]

				X. Zou and K. Calame Signaling Pathways Activated by Oncogenic Forms of Abl Tyrosine Kinase J. Biol. Chem., June 25, 1999; 274(26): 18141 - 18144. [Full Text] [PDF]