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CUTTING EDGE |
*
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;
Department of Surgery, University of Tsukuba School of Medicine, Ibaraki, Japan;
Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan;
§
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; and
¶
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
A recombinant soluble form of human Fas ligand (sFasL) was tested for its chemotactic activity against human and mouse polymorphonuclear neutrophils (PMN) by the Boyden chamber method. sFasL exhibited a potent chemotactic activity against both human and mouse PMN and HL-60 cells when differentiated into neutrophils or monocytes. A neutralizing anti-FasL mAb abolished the chemotactic activity, while control mAb did not. Ligation of Fas by either IgM- or IgG-type anti-Fas mAb also induced PMN migration. PMN derived from lpr mice that express few Fas molecules did not respond to sFasL. In contrast, those derived from lprcg mice that express Fas molecules with a mutated death domain normally responded to sFasL chemotaxis. These results directly indicated a chemotactic activity of sFasL against PMN and suggest a novel signaling function of Fas, which appears to be independent of the death domain-mediated apoptosis.
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 M. D. Josephs, F. R. Bahjat, K. Fukuzuka, R. Ksontini, C. C. Solorzano, C. K. Edwards III, C. L. Tannahill, S. L. D. MacKay, E. M. Copeland III, and L. L. Moldawer Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1196 - R1201. [Abstract] [Full Text] [PDF]
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M. Shimizu, A. Fontana, Y. Takeda, H. Yagita, T. Yoshimoto, and A. Matsuzawa Induction of Antitumor Immunity with Fas/APO-1 Ligand (CD95L)-Transfected Neuroblastoma Neuro-2a Cells J. Immunol., June 15, 1999; 162(12): 7350 - 7357. [Abstract] [Full Text] [PDF]
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L. Ottonello, G. Tortolina, M. Amelotti, and F. Dallegri Soluble Fas Ligand Is Chemotactic for Human Neutrophilic Polymorphonuclear Leukocytes J. Immunol., March 15, 1999; 162(6): 3601 - 3606. [Abstract] [Full Text] [PDF]
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