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CUTTING EDGE |
5 Surrogate Light Chains and Reduced Development Within the Pre-B Cell Compartment1
* Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33101
Although senescent BALB/c mice (
2 years old) have reduced
numbers of small pre-B cells, early pre-B cells
(CD43+CD25+B220+) are present in
comparable numbers within the bone marrow of both young
(3–6-month-old) and senescent BALB/c mice. The transition of
CD43+ pre-B cells to the CD43- pre-B cell
compartments is dependent on proliferation and clonal maturation
dictated by the pre-B cell receptor (µ/
5/VpreB). In vivo,
senescent CD43+B220+ pro-B/early pre-B cells
demonstrated reduction of 5 mRNA, by RT-PCR analysis, and of both
surface and cytoplasmic 5 protein. Decreased 5 protein expression
was also seen among pro-B/pre-B cells derived from senescent bone
marrow after stimulation in vitro with IL-7. We propose that diminished
expression of the 5 surrogate light chain results in decreased pre-B
cell receptor formation and contributes to reduced recruitment of
nascent CD43+ pre-B cells into the CD43- large
and small pre-B cell compartments.
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