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The Journal of Immunology, 1998, 161: 4161-4168.
Copyright © 1998 by The American Association of Immunologists

Dermal Endothelial Cells and Keratinocytes Produce IL-7 In Vivo After Human Schistosoma mansoni Percutaneous Infection1

Olivier Roye2,*, Nadirah Delhem{dagger}, François Trottein{ddagger}, Franck Remoué{ddagger},§, Sophie Nutten{ddagger}, Jean-Pierre Decavel{ddagger}, Myriam Delacre*, Véronique Martinot,||, Jean-Yves Cesbron{dagger},||, Claude Auriault* and Isabelle Wolowczuk*

* Centre National de la Recherche Scientifique, Unité de Recherche Associée 1854, Institut de Biologie de Lille, Lille, France; {dagger} Institut National de la Santé et de la Recherche Médicale, Unité 167, Physiopathologie des Affections Neurodégénératives Transmissibles, Institut Pasteur, Lille, France; {ddagger} Institut National de la Santé et de la Recherche Médicale, Unité 167, Institut Pasteur, Lille, France; § Laboratoire de SOR, European Special Program for Operational and Integrated Research, Saint Louis, Sénégal; Service de Chirurgie Plastique et Reconstructive, Hôpital Roger Salengro, Lille, France; and || Université de Lille II, Lille, France

The parasite Schistosoma mansoni infects its definitive mammalian host through an obligatory cutaneous penetration. In this work, we studied early immune response following migration of larvae through human skin, the first immunocompetent organ encountered by the parasite. For this purpose we used an experimental model of severe combined immunodeficient mice engrafted with human skin and injected with autologous PBL. Six days after percutaneous infection, we observed an infiltration of lymphocytes within the human skin, predominantly composed of CD4+ T cells. Moreover, among the cytokines potentially present in the infected skin, immunohistochemistry analysis revealed an in vivo expression of IL-7 in the epidermal layers and strikingly at the level of vascular endothelium. Using an in vitro coculture system, we showed that the S. mansoni larvae directly trigger IL-7 production by human dermal microvascular endothelial cells but not by keratinocytes. Finally, measurements of IL-7 concentrations in plasma of 187 S. mansoni-infected individuals showed that the youngest, which are also the most infected, displayed the highest IL-7 levels. Together, these findings describe dermal endothelial cells as a novel source of IL-7, a cytokine particularly important in schistosomiasis.




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I. Wolowczuk, S. Nutten, O. Roye, M. Delacre, M. Capron, R. M. Murray, F. Trottein, and C. Auriault
Infection of Mice Lacking Interleukin-7 (IL-7) Reveals an Unexpected Role for IL-7 in the Development of the Parasite Schistosoma mansoni
Infect. Immun., August 1, 1999; 67(8): 4183 - 4190.
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