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T and 
ß T Cells Coinfiltrating in Early B16 Melanoma Lesions
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
We examined whether 
T and 
ß T cells accumulating in
early B16 melanoma lesions regulate NK and NK T cells that attack tumor
cells. Freshly isolated and cultured tumor-infiltrating lymphocyte
(TIL) populations of NK and NK T cells lysed B16 and produced IFN-,
whereas T and a large part of ß T cell populations had no
substantial cytotoxicity against B16 and secreted Th2 cytokines.
Furthermore, the freshly isolated NK1.1+ TIL population
exhibited a higher anti-B16 effect than did splenocytes. T
and ß T cell populations dramatically inhibited the cytotoxicity
of NK and NK T cells in an MHC Kb-dependent manner. Culture
supernatant from T and ß T cell populations inhibited the
proliferation of NK and NK T cell populations but did not affect their
cytotoxicity, suggesting that the released Th2 cytokines are merely
partly involved in the down-modulation of NK-lineage cells.
NK1.1+ cells obtained from TIL of T cell-depleted
mice significantly lysed B16 cells compared with those from control
mice. Finally, anti-Kb Fab mAb injected intralesionally
at an early, but not at a late, stage of development of B16 melanoma
inhibited tumor growth. These findings suggest that Th2-type T
and ß T cells infiltrating in early B16 development inhibit the
tumoricidal activity of NK-lineage cells using their class I molecules
and partly their suppressive cytokines.
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