| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland; Departments of
Immunology and
§
Virology, University Hospital, Utrecht, The Netherlands; and
¶
Unité de Biologie Moléculaire du Gène, Institut Pasteur, Paris, France
T cell maturation in Tcf-1-/- mice deteriorates progressively and halts completely around 6 mo of age. During fetal development thymocyte subpopulations seem normal, although total cell numbers are lower. By 4 to 6 wk of age, obvious blockades in the differentiation of CD4-8- thymocytes are observed at two distinct stages (CD44+25+ and CD44-25-), both of which are normally characterized by extensive proliferation. This lack of thymocyte expansion and/or differentiation was also observed when Tcf-1-/- progenitor cells from the aorta-gonad-mesonephros region (embryonic day 11.5), fetal liver (embryonic day 12.5/14.5), and fetal bone marrow (embryonic day 18.5) were allowed to differentiate in normal thymic lobes (fetal thymic organ cultures) or were injected intrathymically into normal recipients. Despite these apparent defects in thymocyte differentiation and expansion, adult Tcf-1-/- mice are immunocompetent, as they generate virus neutralizing Abs at normal titers. Furthermore, their peripheral T cells have an activated phenotype (increased CD44 and decreased CD62L expression) and proliferate normally in response to Ag or mitogen, suggesting that these cells may have arisen from the early wave of development during embryogenesis and are either long lived or have subsequently been maintained by peripheral expansion. As Tcf-1 is a critical component in the Wnt/ß-catenin signaling pathway, these data suggest that Wnt-like factors play a role in the expansion of double-negative thymocytes.
This article has been cited by other articles:
|
|
 |
|
  D. Kovalovsky, Y. Yu, M. Dose, A. Emmanouilidou, T. Konstantinou, K. Germar, K. Aghajani, Z. Guo, M. Mandal, and F. Gounari {beta}-Catenin/Tcf Determines the Outcome of Thymic Selection in Response to {alpha}{beta}TCR Signaling J. Immunol., September 15, 2009; 183(6): 3873 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-L. Wu, C. Zierold, and E. A. Ranheim Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia Blood, March 26, 2009; 113(13): 3031 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xu, A. Sharma, D. L. Wiest, and J. M. Sen Pre-TCR-Induced {beta}-Catenin Facilitates Traversal through {beta}-Selection J. Immunol., January 15, 2009; 182(2): 751 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Xu, A. Sharma, M. Z. Hossain, D. L. Wiest, and J. M. Sen Sustained Expression of Pre-TCR Induced {beta}-Catenin in Post-{beta}-Selection Thymocytes Blocks T Cell Development J. Immunol., January 15, 2009; 182(2): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Malhotra, Y. Baba, K. P. Garrett, F. J. T. Staal, R. Gerstein, and P. W. Kincade Contrasting Responses of Lymphoid Progenitors to Canonical and Noncanonical Wnt Signals J. Immunol., September 15, 2008; 181(6): 3955 - 3964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W.J. Groen, M. E.C.M. Oud, E. J.M. Schilder-Tol, M. B. Overdijk, D. ten Berge, R. Nusse, M. Spaargaren, and S. T. Pals Illegitimate WNT Pathway Activation by {beta}-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies Cancer Res., September 1, 2008; 68(17): 6969 - 6977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hebenstreit, M. Giaisi, M. K. Treiber, X.-B. Zhang, H.-F. Mi, J. Horejs-Hoeck, K. G. Andersen, P. H. Krammer, A. Duschl, and M. Li-Weber LEF-1 Negatively Controls Interleukin-4 Expression through a Proximal Promoter Regulatory Element J. Biol. Chem., August 15, 2008; 283(33): 22490 - 22497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Z. Hossain, Q. Yu, M. Xu, and J. M. Sen ICAT expression disrupts {beta}-catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells Int. Immunol., July 1, 2008; 20(7): 925 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Huang, R. Wang, H. Xie, W. Shang, S. Manicassamy, and Z. Sun Stabilized {beta}-Catenin Potentiates Fas-Mediated T Cell Apoptosis J. Immunol., May 15, 2008; 180(10): 6586 - 6592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xu, Q. Yu, R. Subrahmanyam, M. J. Difilippantonio, T. Ried, and J. M. Sen {beta}-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo Mol. Cell. Biol., March 1, 2008; 28(5): 1713 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Koch, A. Wilson, M. Cobas, R. Kemler, H. R. MacDonald, and F. Radtke Simultaneous loss of - and {gamma}-catenin does not perturb hematopoiesis or lymphopoiesis Blood, January 1, 2008; 111(1): 160 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jeannet, M. Scheller, L. Scarpellino, S. Duboux, N. Gardiol, J. Back, F. Kuttler, I. Malanchi, W. Birchmeier, A. Leutz, et al. Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin Blood, January 1, 2008; 111(1): 142 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Liang, A. H. Coles, Z. Zhu, J. Zayas, R. Jurecic, J. Kang, and S. N. Jones Noncanonical Wnt signaling promotes apoptosis in thymocyte development J. Exp. Med., December 24, 2007; 204(13): 3077 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, M. Dose, D. Kovalovsky, R. Chang, J. O'Neil, A. T. Look, H. von Boehmer, K. Khazaie, and F. Gounari {beta}-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation Blood, June 15, 2007; 109(12): 5463 - 5472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Melichar, K. Narayan, S. D. Der, Y. Hiraoka, N. Gardiol, G. Jeannet, W. Held, C. A. Chambers, and J. Kang Regulation of {gamma}{delta} Versus {alpha}{beta} T Lymphocyte Differentiation by the Transcription Factor SOX13 Science, January 12, 2007; 315(5809): 230 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Choi, M. W. Park, S. Y. Lee, M.-Y. Jeon, M. Y. Kim, H. K. Lee, J. Yu, H.-J. Kim, K. Han, H. Lee, et al. Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer. Mol. Cancer Ther., September 1, 2006; 5(9): 2428 - 2434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Huang, H. Xie, V. Ioannidis, W. Held, H. Clevers, M. S. Sadim, and Z. Sun Transcriptional Regulation of CD4 Gene Expression by T Cell Factor-1/beta-Catenin Pathway. J. Immunol., April 15, 2006; 176(8): 4880 - 4887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Weerkamp, M. R. M. Baert, B. A. E. Naber, E. E. L. Koster, E. F. E. de Haas, K. R. Atkuri, J. J. M. van Dongen, L. A. Herzenberg, and F. J. T. Staal Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules PNAS, February 28, 2006; 103(9): 3322 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Willinger, T. Freeman, M. Herbert, H. Hasegawa, A. J. McMichael, and M. F. C. Callan Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo J. Immunol., February 1, 2006; 176(3): 1439 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xie, Z. Huang, M. S. Sadim, and Z. Sun Stabilized {beta}-Catenin Extends Thymocyte Survival by Up-Regulating Bcl-xL J. Immunol., December 15, 2005; 175(12): 7981 - 7988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goux, J. D. Coudert, D. Maurice, L. Scarpellino, G. Jeannet, S. Piccolo, K. Weston, J. Huelsken, and W. Held Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival Blood, September 1, 2005; 106(5): 1726 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Terra, I. Louis, R. Le Blanc, S. Ouellet, J. C. Zuniga-Pflucker, and C. Perreault T-cell generation by lymph node resident progenitor cells Blood, July 1, 2005; 106(1): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Ranheim, H. C. K. Kwan, T. Reya, Y.-K. Wang, I. L. Weissman, and U. Francke Frizzled 9 knock-out mice have abnormal B-cell development Blood, March 15, 2005; 105(6): 2487 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. van Amerongen, M. Nawijn, J. Franca-Koh, J. Zevenhoven, H. van der Gulden, J. Jonkers, and A. Berns Frat is dispensable for canonical Wnt signaling in mammals Genes & Dev., February 15, 2005; 19(4): 425 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Everly Jr., S. Kusano, and N. Raab-Traub Accumulation of Cytoplasmic {beta}-Catenin and Nuclear Glycogen Synthase Kinase 3{beta} in Epstein-Barr Virus-Infected Cells J. Virol., November 1, 2004; 78(21): 11648 - 11655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hoflinger, K. Kesavan, M. Fuxa, C. Hutter, B. Heavey, F. Radtke, and M. Busslinger Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors J. Immunol., September 15, 2004; 173(6): 3935 - 3944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tournoy, X. Bossuyt, A. Snellinx, M. Regent, M. Garmyn, L. Serneels, P. Saftig, K. Craessaerts, B. De Strooper, and D. Hartmann Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice Hum. Mol. Genet., July 1, 2004; 13(13): 1321 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. B. Derksen, E. Tjin, H. P. Meijer, M. D. Klok, H. D. Mac Gillavry, M. H. J. van Oers, H. M. Lokhorst, A. C. Bloem, H. Clevers, R. Nusse, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells PNAS, April 20, 2004; 101(16): 6122 - 6127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Coletta, A. M. Muller, E. A. Jones, B. Muhl, S. Holwell, D. Clarke, J. L. Meade, G. P. Cook, G. Hawcroft, F. Ponchel, et al. Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis Blood, February 1, 2004; 103(3): 1050 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cobas, A. Wilson, B. Ernst, S. J.C. Mancini, H. R. MacDonald, R. Kemler, and F. Radtke {beta}-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis J. Exp. Med., January 20, 2004; 199(2): 221 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. T. Staal, F. Weerkamp, M. R. M. Baert, C. M. M. van den Burg, M. van Noort, E. F. E. de Haas, and J. J. M. van Dongen Wnt Target Genes Identified by DNA Microarrays in Immature CD34+ Thymocytes Regulate Proliferation and Cell Adhesion J. Immunol., January 15, 2004; 172(2): 1099 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Kaufman, P. Zhou, H. A. Pasolli, M. Rendl, D. Bolotin, K.-C. Lim, X. Dai, M.-L. Alegre, and E. Fuchs GATA-3: an unexpected regulator of cell lineage determination in skin Genes & Dev., September 1, 2003; 17(17): 2108 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Dorfman, H. A. Greisman, and A. Shahsafaei Loss of Expression of the WNT/{beta}-Catenin-Signaling Pathway Transcription Factors Lymphoid Enhancer Factor-1 (LEF-1) and T Cell Factor-1 (TCF-1) in a Subset of Peripheral T Cell Lymphomas Am. J. Pathol., May 1, 2003; 162(5): 1539 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ferrero, W. Held, A. Wilson, F. Tacchini-Cottier, F. Radtke, and H. R. MacDonald Mouse CD11c+ B220+ Gr1+ plasmacytoid dendritic cells develop independently of the T-cell lineage Blood, September 26, 2002; 100(8): 2852 - 2857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Kieper and S. C. Jameson Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands PNAS, November 9, 1999; 96(23): 13306 - 13311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Roose, G. Huls, M. v. Beest, P. Moerer, K. v. d. Horn, R. Goldschmeding, T. Logtenberg, and H. Clevers Synergy Between Tumor Suppressor APC and the -Catenin-Tcf4 Target Tcf1 Science, September 17, 1999; 285(5435): 1923 - 1926. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. MURRE Role of Helix-Loop-Helix Proteins in Lymphocyte Development Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 39 - 44. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
