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Production1
*
Department of Immunology and Medical Zoology,
Laboratory of Host Defenses, Institute for Advanced Medical Sciences, and
Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
IL-18 is a product of macrophages and with IL-12 strikingly induces
IFN-
production from T, B, and NK cells. Furthermore, IL-18 and
IL-12 synergize for IFN- production from Th1 cells, although this
combination fails to affect Th2 cells. In this study, we show that
IL-12 and IL-18 promptly and synergistically induce T and B cells to
develop into IFN--producing cells without engaging their Ag
receptors. We also studied the mechanism underlying differences
in IL-18 responsiveness between Th1 and Th2 cells. Pretreatment of T or
B cells with IL-12 rendered them responsive to IL-18, which induces
cell proliferation and IFN- production. These IL-12-stimulated cells
had both high and low affinity IL-18R and an increased IL-18R mRNA
expression. In particular, IL-12-stimulated T cells strongly and
continuously expressed IL-18R mRNA. However, when T cells developed
into Th1 cells after stimulation with anti-CD3 and IL-12, they
lowered this IL-12-induced-IL-18R mRNA expression. Then, such T cells
showed a dominant response to anti-CD3 by IFN- production when
they were subsequently stimulated with anti-CD3 and IL-18. In
contrast, Th2 cells did not express IL-18R mRNA and failed to produce
IFN- in response to anti-CD3 and IL-18, although they produced a
substantial amount of IFN- in response to anti-CD3 and IL-12.
However, when Th1 and Th2 cells were stimulated with anti-CD3,
IL-12, and IL-18, only the Th1 cells markedly augmented IFN-
production in response to IL-18, suggesting that IL-18 responsiveness
between Th1 and Th2 cells resulted from their differential expression
of IL-18R.
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D. Durali, M.-G. de Goer de Herve, J. Giron-Michel, B. Azzarone, J.-F. Delfraissy, and Y. Taoufik In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment Blood, December 1, 2003; 102(12): 4084 - 4089. [Abstract] [Full Text] [PDF]
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G. Fantuzzi, N. K. Banda, C. Guthridge, A. Vondracek, S.-H. Kim, B. Siegmund, T. Azam, J. A. Sennello, C. A. Dinarello, and W. P. Arend Generation and characterization of mice transgenic for human IL-18-binding protein isoform a J. Leukoc. Biol., November 1, 2003; 74(5): 889 - 896. [Abstract] [Full Text] [PDF]
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T. W. Gobel, K. Schneider, B. Schaerer, I. Mejri, F. Puehler, S. Weigend, P. Staeheli, and B. Kaspers IL-18 Stimulates the Proliferation and IFN-{gamma} Release of CD4+ T Cells in the Chicken: Conservation of a Th1-Like System in a Nonmammalian Species J. Immunol., August 15, 2003; 171(4): 1809 - 1815. [Abstract] [Full Text] [PDF]
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M. M. Gherardi, J. C. Ramirez, and M. Esteban IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system J. Gen. Virol., August 1, 2003; 84(8): 1961 - 1972. [Abstract] [Full Text] [PDF]
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T. Plitz, P. Saint-Mezard, M. Satho, S. Herren, C. Waltzinger, M. de Carvalho Bittencourt, M. H. Kosco-Vilbois, and Y. Chvatchko IL-18 Binding Protein Protects Against Contact Hypersensitivity J. Immunol., August 1, 2003; 171(3): 1164 - 1171. [Abstract] [Full Text] [PDF]
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E.-M. Boneberg and T. Hartung Febrile Temperatures Attenuate IL-1{beta} Release by Inhibiting Proteolytic Processing of the Proform and Influence Th1/Th2 Balance by Favoring Th2 Cytokines J. Immunol., July 15, 2003; 171(2): 664 - 668. [Abstract] [Full Text] [PDF]
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J. H. Bream, R. E. Curiel, C.-R. Yu, C. E. Egwuagu, M. J. Grusby, T. M. Aune, and H. A. Young IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-{gamma} expression in murine NK cells Blood, July 1, 2003; 102(1): 207 - 214. [Abstract] [Full Text] [PDF]
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C. Wu, P. Sakorafas, R. Miller, D. McCarthy, S. Scesney, R. Dixon, and T. Ghayur IL-18 Receptor {beta}-Induced Changes in the Presentation of IL-18 Binding Sites Affect Ligand Binding and Signal Transduction J. Immunol., June 1, 2003; 170(11): 5571 - 5577. [Abstract] [Full Text] [PDF]
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D. Fairweather, S. Yusung, S. Frisancho, M. Barrett, S. Gatewood, R. Steele, and N. R. Rose IL-12 Receptor {beta}1 and Toll-Like Receptor 4 Increase IL-1{beta}- and IL-18-Associated Myocarditis and Coxsackievirus Replication J. Immunol., May 1, 2003; 170(9): 4731 - 4737. [Abstract] [Full Text] [PDF]
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A. Ito, A. Matejuk, C. Hopke, H. Drought, J. Dwyer, A. Zamora, S. Subramanian, A. A. Vandenbark, and H. Offner Transfer of Severe Experimental Autoimmune Encephalomyelitis by IL-12- and IL-18-Potentiated T Cells Is Estrogen Sensitive J. Immunol., May 1, 2003; 170(9): 4802 - 4809. [Abstract] [Full Text] [PDF]
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T. Yoshimoto, B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, et al. Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice J. Exp. Med., April 21, 2003; 197(8): 997 - 1005. [Abstract] [Full Text] [PDF]
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E. Kikawada, D. M. Lenda, and V. R. Kelley IL-12 Deficiency in MRL-Faslpr Mice Delays Nephritis and Intrarenal IFN-{gamma} Expression, and Diminishes Systemic Pathology J. Immunol., April 1, 2003; 170(7): 3915 - 3925. [Abstract] [Full Text] [PDF]
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M. de Fost, R. A. Hartskeerl, M. R. Groenendijk, and T. van der Poll Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated with Leptospira interrogans Clin. Vaccine Immunol., March 1, 2003; 10(2): 332 - 335. [Abstract] [Full Text] [PDF]
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T. Kambayashi, E. Assarsson, A. E. Lukacher, H.-G. Ljunggren, and P. E. Jensen Memory CD8+ T Cells Provide an Early Source of IFN-{gamma} J. Immunol., March 1, 2003; 170(5): 2399 - 2408. [Abstract] [Full Text] [PDF]
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J. A. Gracie, S. E. Robertson, and I. B. McInnes Interleukin-18 J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224. [Abstract] [Full Text] [PDF]
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H. K. Takahashi, T. Morichika, H. Iwagaki, T. Yoshino, R. Tamura, S. Saito, S. Mori, T. Akagi, N. Tanaka, and M. Nishibori Effect of {beta}2-Adrenergic Receptor Stimulation on Interleukin-18-Induced Intercellular Adhesion Molecule-1 Expression and Cytokine Production J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 634 - 642. [Abstract] [Full Text] [PDF]
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M. H. Qureshi, A. G. Harmsen, and B. A. Garvy IL-10 Modulates Host Responses and Lung Damage Induced by Pneumocystis carinii Infection J. Immunol., January 15, 2003; 170(2): 1002 - 1009. [Abstract] [Full Text] [PDF]
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A. M. Harandi, K. Eriksson, and J. Holmgren A Protective Role of Locally Administered Immunostimulatory CpG Oligodeoxynucleotide in a Mouse Model of Genital Herpes Infection J. Virol., December 20, 2002; 77(2): 953 - 962. [Abstract] [Full Text] [PDF]
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J. A. Symons, E. Adams, D. C. Tscharke, P. C. Reading, H. Waldmann, and G. L. Smith The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model J. Gen. Virol., November 1, 2002; 83(11): 2833 - 2844. [Abstract] [Full Text] [PDF]
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K. Kimura, K. Kakimi, S. Wieland, L. G. Guidotti, and F. V. Chisari Interleukin-18 Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice J. Virol., October 2, 2002; 76(21): 10702 - 10707. [Abstract] [Full Text] [PDF]
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D. Dreher, M. Kok, C. Obregon, S. G. Kiama, P. Gehr, and L. P. Nicod Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells J. Leukoc. Biol., October 1, 2002; 72(4): 743 - 751. [Abstract] [Full Text] [PDF]
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A. Morinobu, M. Gadina, W. Strober, R. Visconti, A. Fornace, C. Montagna, G. M. Feldman, R. Nishikomori, and J. J. O'Shea STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation PNAS, September 17, 2002; 99(19): 12281 - 12286. [Abstract] [Full Text] [PDF]
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H. Konishi, H. Tsutsui, T. Murakami, S. Yumikura-Futatsugi, K.-i. Yamanaka, M. Tanaka, Y. Iwakura, N. Suzuki, K. Takeda, S. Akira, et al. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions PNAS, August 20, 2002; 99(17): 11340 - 11345. [Abstract] [Full Text] [PDF]
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A. Ariel, D. Novick, M. Rubinstein, C. A. Dinarello, O. Lider, and R. Hershkoviz IL-12 and IL-18 induce MAP kinase-dependent adhesion of T cells to extracellular matrix components J. Leukoc. Biol., July 1, 2002; 72(1): 192 - 198. [Abstract] [Full Text] [PDF]
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R. B. Smeltz, J. Chen, R. Ehrhardt, and E. M. Shevach Role of IFN-{gamma} in Th1 Differentiation: IFN-{gamma} Regulates IL-18R{alpha} Expression by Preventing the Negative Effects of IL-4 and by Inducing/Maintaining IL-12 Receptor {beta}2 Expression J. Immunol., June 15, 2002; 168(12): 6165 - 6172. [Abstract] [Full Text] [PDF]
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D. Arnold, C. Wasem, P. Juillard, P. Graber, I. Cima, C. Frutschi, S. Herren, S. Jakob, S. Alouani, C. Mueller, et al. IL-18-independent cytotoxic T lymphocyte activation and IFN-{gamma} production during experimental acute graft-versus-host disease Int. Immunol., May 1, 2002; 14(5): 503 - 511. [Abstract] [Full Text] [PDF]
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