| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520; and
University of Utrecht, Department of Cell Biology, Medical School ACU, Utrecht, The Netherlands
In specialized APCs, MHC class II molecules are synthesized in the endoplasmic reticulum and transported through the Golgi apparatus to organelles of the endocytic pathway collectively called MHC class II compartments (MIICs). There, the class II-associated invariant chain is degraded, and peptides derived from internalized Ag bind to empty class II in a reaction that is facilitated by the class II-like molecule HLA-DM. An mAb raised to highly purified, immunoisolated MIICs from human B lymphoblastoid cells recognized CD82, a member of the tetraspan family of integral membrane proteins. Subcellular fractionation, immunofluorescence microscopy, and immunoelectron microscopy showed that CD82 is highly enriched in MIICs, particularly in their internal membranes. Coprecipitation analysis showed that CD82 associates in MIICs with class II, DM, and HLA-DO (an inhibitor of peptide loading that binds DM). Similar experiments showed CD63, another tetraspan protein found in MIICs, also associates with these molecules in the compartment and that CD82 and CD63 associate with each other. Preclearing experiments demonstrated that both CD82 and CD63 form complexes with DM-associated class II and DM-associated DO. The ability of CD82 and CD63 to form complexes with class II, DM, and DO in MIICs suggests that the tetraspan proteins may play an important role in the late stages of MHC class II maturation.
This article has been cited by other articles:
|
|
 |
|
  C. Xu, Y. H. Zhang, M. Thangavel, M. M. Richardson, L. Liu, B. Zhou, Y. Zheng, R. S. Ostrom, and X. A. Zhang CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts FASEB J, October 1, 2009; 23(10): 3273 - 3288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Yuan, S.-J. Kang, J. E. Evans, and P. Cresswell Natural Lipid Ligands Associated with Human CD1d Targeted to Different Subcellular Compartments J. Immunol., April 15, 2009; 182(8): 4784 - 4791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schroder, R. Lullmann-Rauch, N. Himmerkus, I. Pleines, B. Nieswandt, Z. Orinska, F. Koch-Nolte, B. Schroder, M. Bleich, and P. Saftig Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function Mol. Cell. Biol., February 15, 2009; 29(4): 1083 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Fallas, W. Yi, N. A. Draghi, H. M. O'Rourke, and L. K. Denzin Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function J. Immunol., February 1, 2007; 178(3): 1488 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Unternaehrer, A. Chow, M. Pypaert, K. Inaba, and I. Mellman The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface PNAS, January 2, 2007; 104(1): 234 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Artavanis-Tsakonas, J. C. Love, H. L. Ploegh, and J. M. Vyas Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification PNAS, October 24, 2006; 103(43): 15945 - 15950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Poloso, L. K. Denzin, and P. A. Roche CDw78 Defines MHC Class II-Peptide Complexes That Require Ii Chain-Dependent Lysosomal Trafficking, Not Localization to a Specific Tetraspanin Membrane Microdomain J. Immunol., October 15, 2006; 177(8): 5451 - 5458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Karacsonyi, T. Bedke, N. Hinrichsen, R. Schwinzer, and R. Lindner MHC II molecules and invariant chain reside in membranes distinct from conventional lipid rafts J. Leukoc. Biol., November 1, 2005; 78(5): 1097 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Lehmann, N. M. Sherer, C. B. Marks, M. Pypaert, and W. Mothes Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells J. Cell Biol., July 18, 2005; 170(2): 317 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Modiano, Y. E. Lu, and P. Cresswell Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-{gamma}-inducible cofactor PNAS, June 14, 2005; 102(24): 8680 - 8685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Kim, D. Guo, and D. B. Sant'Angelo Coevolution of TCR-MHC interactions: Conserved MHC tertiary structure is not sufficient for interactions with the TCR PNAS, May 17, 2005; 102(20): 7263 - 7267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Deshaies, A. Brunet, D. A. Diallo, L. K. Denzin, A. Samaan, and J. Thibodeau A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM PNAS, May 3, 2005; 102(18): 6443 - 6448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lin, L. A. Kimpler, T. V. Naismith, J. M. Lauer, and P. I. Hanson Interaction of the Mammalian Endosomal Sorting Complex Required for Transport (ESCRT) III Protein hSnf7-1 with Itself, Membranes, and the AAA+ ATPase SKD1 J. Biol. Chem., April 1, 2005; 280(13): 12799 - 12809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Delaguillaumie, J. Harriague, S. Kohanna, G. Bismuth, E. Rubinstein, M. Seigneuret, and H. Conjeaud Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation J. Cell Sci., October 15, 2004; 117(22): 5269 - 5282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Mantegazza, M. M. Barrio, S. Moutel, L. Bover, M. Weck, P. Brossart, J.-L. Teillaud, and J. Mordoh CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells Blood, August 15, 2004; 104(4): 1183 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Karacsonyi, R. Knorr, A. Fulbier, and R. Lindner Association of Major Histocompatibility Complex II with Cholesterol- and Sphingolipid-rich Membranes Precedes Peptide Loading J. Biol. Chem., August 13, 2004; 279(33): 34818 - 34826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Fallas, H. M. Tobin, O. Lou, D. Guo, D. B. Sant'Angelo, and L. K. Denzin Ectopic Expression of HLA-DO in Mouse Dendritic Cells Diminishes MHC Class II Antigen Presentation J. Immunol., August 1, 2004; 173(3): 1549 - 1560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Wilson, D. El-Sukkari, and J. A. Villadangos Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis Blood, March 15, 2004; 103(6): 2187 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duffield, E.-J. Kamsteeg, A. N. Brown, P. Pagel, and M. J. Caplan The tetraspanin CD63 enhances the internalization of the H,K-ATPase {beta}-subunit PNAS, December 23, 2003; 100(26): 15560 - 15565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Ackerman, C. Kyritsis, R. Tampe, and P. Cresswell Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens PNAS, October 28, 2003; 100(22): 12889 - 12894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kretschmer, A. Jungebloud, J. Stopkowicz, B. Stoermann, R. Hoffmann, and S. Weiss Antibody Repertoire and Gene Expression Profile: Implications for Different Developmental and Functional Traits of Splenic and Peritoneal B-1 Lymphocytes J. Immunol., August 1, 2003; 171(3): 1192 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. A. Zhang, B. He, B. Zhou, and L. Liu Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration J. Biol. Chem., July 11, 2003; 278(29): 27319 - 27328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. A. Zhang, W. S. Lane, S. Charrin, E. Rubinstein, and L. Liu EWI2/PGRL Associates with the Metastasis Suppressor KAI1/CD82 and Inhibits the Migration of Prostate Cancer Cells Cancer Res., May 15, 2003; 63(10): 2665 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Ackerman and P. Cresswell Regulation of MHC Class I Transport in Human Dendritic Cells and the Dendritic-Like Cell Line KG-1 J. Immunol., April 15, 2003; 170(8): 4178 - 4188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wubbolts, R. S. Leckie, P. T. M. Veenhuizen, G. Schwarzmann, W. Mobius, J. Hoernschemeyer, J.-W. Slot, H. J. Geuze, and W. Stoorvogel Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes. POTENTIAL IMPLICATIONS FOR THEIR FUNCTION AND MULTIVESICULAR BODY FORMATION J. Biol. Chem., March 21, 2003; 278(13): 10963 - 10972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Hegde, R. A. Tomazin, T. W. Wisner, C. Dunn, J. M. Boname, D. M. Lewinsohn, and D. C. Johnson Inhibition of HLA-DR Assembly, Transport, and Loading by Human Cytomegalovirus Glycoprotein US3: a Novel Mechanism for Evading Major Histocompatibility Complex Class II Antigen Presentation J. Virol., October 2, 2002; 76(21): 10929 - 10941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Cebulla, D. M. Miller, Y. Zhang, B. M. Rahill, P. Zimmerman, J. M. Robinson, and D. D. Sedmak Human Cytomegalovirus Disrupts Constitutive MHC Class II Expression J. Immunol., July 1, 2002; 169(1): 167 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yang, C. Claas, S.-K. Kraeft, L. B. Chen, Z. Wang, J. A. Kreidberg, and M. E. Hemler Palmitoylation of Tetraspanin Proteins: Modulation of CD151 Lateral Interactions, Subcellular Distribution, and Integrin-dependent Cell Morphology Mol. Biol. Cell, March 1, 2002; 13(3): 767 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Delaguillaumie, C. Lagaudriere-Gesbert, M. R. Popoff, and H. Conjeaud Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes J. Cell Sci., January 15, 2002; 115(2): 433 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Weber, C. T. Dao, J. Jun, J. L. Wigal, and P. E. Jensen Transmembrane Domain-Mediated Colocalization of HLA-DM and HLA-DR Is Required for Optimal HLA-DM Catalytic Activity J. Immunol., November 1, 2001; 167(9): 5167 - 5174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Seigneuret, A. Delaguillaumie, C. Lagaudriere-Gesbert, and H. Conjeaud Structure of the Tetraspanin Main Extracellular Domain. A PARTIALLY CONSERVED FOLD WITH A STRUCTURALLY VARIABLE DOMAIN INSERTION J. Biol. Chem., October 19, 2001; 276(43): 40055 - 40064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qi and S. Ostrand-Rosenberg H2-O Inhibits Presentation of Bacterial Superantigens, but Not Endogenous Self Antigens J. Immunol., August 1, 2001; 167(3): 1371 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Lith, M. van Ham, A. Griekspoor, E. Tjin, D. Verwoerd, J. Calafat, H. Janssen, E. Reits, L. Pastoors, and J. Neefjes Regulation of MHC Class II Antigen Presentation by Sorting of Recycling HLA-DM/DO and Class II within the Multivesicular Body J. Immunol., July 15, 2001; 167(2): 884 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Gondre-Lewis, A. E. Moquin, and J. R. Drake Prolonged Antigen Persistence Within Nonterminal Late Endocytic Compartments of Antigen-Specific B Lymphocytes J. Immunol., June 1, 2001; 166(11): 6657 - 6664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Engering and J. Pieters Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells Int. Immunol., February 1, 2001; 13(2): 127 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Baron, G Raposo, S. Scholl, H Bausinger, D Tenza, A Bohbot, P Pouillart, B Goud, D Hanau, and J Salamero Modulation of MHC class II transport and lysosome distribution by macrophage-colony stimulating factor in human dendritic cells derived from monocytes J. Cell Sci., January 3, 2001; 114(5): 999 - 1010. [Abstract] [PDF]
|
|
|
|
|
|
K.-P. Knobeloch, M. D. Wright, A. F. Ochsenbein, O. Liesenfeld, J. Löhler, R. M. Zinkernagel, I. Horak, and Z. Orinska Targeted Inactivation of the Tetraspanin CD37 Impairs T-Cell-Dependent B-Cell Response under Suboptimal Costimulatory Conditions Mol. Cell. Biol., August 1, 2000; 20(15): 5363 - 5369. [Abstract] [Full Text]
|
|
|
|
|
|
K. Denzer, M. van Eijk, M. J. Kleijmeer, E. Jakobson, C. de Groot, and H. J. Geuze Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface J. Immunol., August 1, 2000; 165(3): 1259 - 1265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kobayashi, U. M. Vischer, C. Rosnoblet, C. Lebrand, M. Lindsay, R. G. Parton, E. K. O. Kruithof, and J. Gruenberg The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells Mol. Biol. Cell, May 1, 2000; 11(5): 1829 - 1843. [Abstract] [Full Text]
|
|
|
|
|
|
B. Arunachalam, U. T. Phan, H. J. Geuze, and P. Cresswell Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) PNAS, January 18, 2000; 97(2): 745 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Denzer, M. Kleijmeer, H. Heijnen, W Stoorvogel, and H. Geuze Exosome: from internal vesicle of the multivesicular body to intercellular signaling device J. Cell Sci., January 10, 2000; 113(19): 3365 - 3374. [Abstract] [PDF]
|
|
|
|
|
|
C. Thery, A. Regnault, J. Garin, J. Wolfers, L. Zitvogel, P. Ricciardi-Castagnoli, G. Raposo, and S. Amigorena Molecular Characterization of Dendritic Cell-Derived Exosomes: Selective Accumulation of the Heat Shock Protein Hsc73 J. Cell Biol., November 1, 1999; 147(3): 599 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Antoine, T Lang, E Prina, N Courret, and R Hellio H-2M molecules, like MHC class II molecules, are targeted to parasitophorous vacuoles of Leishmania-infected macrophages and internalized by amastigotes of L. amazonensis and L. mexicana J. Cell Sci., January 8, 1999; 112(15): 2559 - 2570. [Abstract] [PDF]
|
|
|
|
|
|
A. Brunet, A. Samaan, F. Deshaies, T. J. Kindt, and J. Thibodeau Functional Characterization of a Lysosomal Sorting Motif in the Cytoplasmic Tail of HLA-DObeta J. Biol. Chem., November 17, 2000; 275(47): 37062 - 37071. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
