|
|
||||||||
-Galactosylceramide Specifically Stimulates V
14+ NK T Lymphocytes1



*
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;
Pharmaceutical Research laboratory, Kirin Brewery Co., Takasaki-shi, Gumna, Japan;
Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, MA 02115;
§
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111; and
¶
CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, Chuo, Chiba, Japan
Mouse CD1 (mCD1) glycoproteins are known to present peptides, while
human CD1 molecules present glycolipids. In mice, mCD1-autoreactive NK
T cells play critical roles in various immune responses, through the
secretion of high amounts of cytokines. This study was initiated to
determine whether glycolipids are involved in the autorecognition of
mCD1 by NK T cells.
-Galactosylceramide (
-GalCer) was the only
glycolipid tested capable of eliciting an mCD1-restricted response by
splenic T cells. Moreover, splenic T cells derived from mCD1-deficient
mice were not stimulated by
-GalCer, suggesting that the responsive
T cells are selected by mCD1. Using cytoflow techniques, we confirmed
that, in response to
-GalCer, IFN-
-secreting cells displayed an
NK T cell phenotype. The predominance of IFN-
vs IL-4, however, is
determined by the type of mCD1+ APC, suggesting the
potential for APC regulation of cytokine production by NK T cells.
Among a panel of 10 mCD1-autoreactive T cell hybridomas, only the ones
that express the typical V
14J
281 TCR rearrangement of NK T cells
responded to
-GalCer. Fixation or treatment of mCD1+
APCs with an inhibitor of endosomal acidification and the use of mCD1
mutants unable to traffic through endosome still allowed
-GalCer to
stimulate NK T cells. Thus, endosomal trafficking and Ag processing are
not required for glycolipid recognition. In summary,
-GalCer might
be the autologous ligand, or a mimic of a glycolipid ligand, involved
in the mCD1-mediated stimulation of NK T cells.
This article has been cited by other articles:
![]() |
A. Mencarelli, B. Renga, M. Migliorati, S. Cipriani, E. Distrutti, L. Santucci, and S. Fiorucci The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis J. Immunol., November 15, 2009; 183(10): 6657 - 6666. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Lindqvist, J. Persson, K. Thorn, and A. M. Harandi The Mucosal Adjuvant Effect of {alpha}-Galactosylceramide for Induction of Protective Immunity to Sexually Transmitted Viral Infection J. Immunol., May 15, 2009; 182(10): 6435 - 6443. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. J. Renukaradhya, M. A. Khan, D. Shaji, and R. R. Brutkiewicz Vesicular Stomatitis Virus Matrix Protein Impairs CD1d-Mediated Antigen Presentation through Activation of the p38 MAPK Pathway J. Virol., December 15, 2008; 82(24): 12535 - 12542. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. J. Webb, R. L. Giuntoli II, O. Rogers, J. Schneck, and M. Oelke Ascites Specific Inhibition of CD1d-Mediated Activation of Natural Killer T Cells Clin. Cancer Res., December 1, 2008; 14(23): 7652 - 7658. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Vas, J. Mattner, S. Richardson, R. Ndonye, J. P. Gaughan, A. Howell, and M. Monestier Regulatory Roles for NKT Cell Ligands in Environmentally Induced Autoimmunity J. Immunol., November 15, 2008; 181(10): 6779 - 6788. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Williams, J. M. Lumsden, X. Yu, L. Feigenbaum, J. Zhang, S. M. Steinberg, and R. J. Hodes Regulation of Thymic NKT Cell Development by the B7-CD28 Costimulatory Pathway J. Immunol., July 15, 2008; 181(2): 907 - 917. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Tsukamoto, M. Ohtsuji, W. Shiroiwa, Q. Lin, K. Nakamura, H. Tsurui, Y. Jiang, K. Sudo, H. Nishimura, T. Shirai, et al. Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis J. Immunol., April 1, 2008; 180(7): 4530 - 4539. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Torres, C. Paget, J. Fontaine, T. Mallevaey, T. Matsuoka, T. Maruyama, S. Narumiya, M. Capron, P. Gosset, C. Faveeuw, et al. Prostaglandin D2 Inhibits the Production of IFN-{gamma} by Invariant NK T Cells: Consequences in the Control of B16 Melanoma J. Immunol., January 15, 2008; 180(2): 783 - 792. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Hager, A. Hawwari, J. L. Matsuda, M. S. Krangel, and L. Gapin Multiple Constraints at the Level of TCR{alpha} Rearrangement Impact V{alpha}14i NKT Cell Development J. Immunol., August 15, 2007; 179(4): 2228 - 2234. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Coppieters, K. Van Beneden, P. Jacques, P. Dewint, A. Vervloet, B. Vander Cruyssen, S. Van Calenbergh, G. Chen, R. W. Franck, G. Verbruggen, et al. A Single Early Activation of Invariant NK T Cells Confers Long-Term Protection against Collagen-Induced Arthritis in a Ligand-Specific Manner J. Immunol., August 15, 2007; 179(4): 2300 - 2309. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, and A. L. Yu Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids PNAS, June 19, 2007; 104(25): 10299 - 10304. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Kishimoto, T. Ohteki, N. Yajima, K. Kawahara, M. Natsui, S. Kawarasaki, K. Hamada, Y. Horie, Y. Kubo, S. Arase, et al. The Pten/PI3K pathway governs the homeostasis of V{alpha}14iNKT cells Blood, April 15, 2007; 109(8): 3316 - 3324. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Coppieters, P. Dewint, K. Van Beneden, P. Jacques, S. Seeuws, G. Verbruggen, D. Deforce, and D. Elewaut NKT cells: manipulable managers of joint inflammation Rheumatology, April 1, 2007; 46(4): 565 - 571. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Cheng, A. Ueno, S. Cho, J. S. Im, S. Golby, S. Hou, S. A. Porcelli, and Y. Yang Efficient Activation of V{alpha}14 Invariant NKT Cells by Foreign Lipid Antigen Is Associated with Concurrent Dendritic Cell-Specific Self Recognition J. Immunol., March 1, 2007; 178(5): 2755 - 2762. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Paduraru, L. Spiridon, W. Yuan, G. Bricard, X. Valencia, S. A. Porcelli, P. A. Illarionov, G. S. Besra, S. M. Petrescu, A.-J. Petrescu, et al. An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and beta2-Microglobulin J. Biol. Chem., December 29, 2006; 281(52): 40369 - 40378. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Yanagisawa, M. A. Exley, X. Jiang, N. Ohkochi, M. Taniguchi, and K.-i. Seino Hyporesponsiveness to Natural Killer T-Cell Ligand {alpha}-Galactosylceramide in Cancer-Bearing State Mediated by CD11b+ Gr-1+ Cells Producing Nitric Oxide Cancer Res., December 1, 2006; 66(23): 11441 - 11446. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Ueda, H. Kuki, D. Kamimura, S. Sawa, K. Seino, T. Tashiro, K.-i. Fushuku, M. Taniguchi, T. Hirano, and M. Murakami CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4 Int. Immunol., September 1, 2006; 18(9): 1397 - 1404. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Nagaraj, C Ziske, J Strehl, D Messmer, T Sauerbruch, and I. Schmidt-Wolf Dendritic cells pulsed with alpha-galactosylceramide induce anti-tumor immunity against pancreatic cancer in vivo Int. Immunol., August 1, 2006; 18(8): 1279 - 1283. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. S. Franki, K. Van Beneden, P. Dewint, K. J. L. Hammond, S. Lambrecht, G. Leclercq, M. Kronenberg, D. Deforce, and D. Elewaut A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells PNAS, June 13, 2006; 103(24): 9160 - 9165. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Kjer-Nielsen, N. A. Borg, D. G. Pellicci, T. Beddoe, L. Kostenko, C. S. Clements, N. A. Williamson, M. J. Smyth, G. S. Besra, H. H. Reid, et al. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition J. Exp. Med., March 20, 2006; 203(3): 661 - 673. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Schumann, M. P. Mycko, P. Dellabona, G. Casorati, and H. R. MacDonald Cutting Edge: Influence of the TCR Vbeta Domain on the Selection of Semi-Invariant NKT Cells by Endogenous Ligands J. Immunol., February 15, 2006; 176(4): 2064 - 2068. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Cain, J. A. Smith, J. K. Ondr, B. Wang, and J. D. Katz NKT Cells and IFN-{gamma} Establish the Regulatory Environment for the Control of Diabetogenic T Cells in the Nonobese Diabetic Mouse J. Immunol., February 1, 2006; 176(3): 1645 - 1654. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Tachibana, H. Onodera, T. Tsuruyama, A. Mori, S. Nagayama, H. Hiai, and M. Imamura Increased Intratumor V{alpha}24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas Clin. Cancer Res., October 15, 2005; 11(20): 7322 - 7327. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. J. Renukaradhya, T. J. R. Webb, M. A. Khan, Y. L. Lin, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK J. Immunol., October 1, 2005; 175(7): 4301 - 4308. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. C. Yue, A. Shaulov, R. Wang, S. P. Balk, and M. A. Exley CD1d ligation on human monocytes directly signals rapid NF-{kappa}B activation and production of bioactive IL-12 PNAS, August 16, 2005; 102(33): 11811 - 11816. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Matsuda, T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura {alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 22 - 31. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. A. Lang, P. A. Illarionov, A. Glatman-Freedman, G. S. Besra, and M. L. Lang BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments Int. Immunol., July 1, 2005; 17(7): 899 - 908. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Wesley, S. H. Robbins, S. Sidobre, M. Kronenberg, S. Terrizzi, and L. Brossay Cutting Edge: IFN-{gamma} Signaling to Macrophages Is Required for Optimal V{alpha}14i NK T/NK Cell Cross-Talk J. Immunol., April 1, 2005; 174(7): 3864 - 3868. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. P. Lawton, T. I. Prigozy, L. Brossay, B. Pei, A. Khurana, D. Martin, T. Zhu, K. Spate, M. Ozga, S. Honing, et al. The Mouse CD1d Cytoplasmic Tail Mediates CD1d Trafficking and Antigen Presentation by Adaptor Protein 3-Dependent and -Independent Mechanisms J. Immunol., March 15, 2005; 174(6): 3179 - 3186. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Schmieg, G. Yang, R. W. Franck, N. Van Rooijen, and M. Tsuji Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion PNAS, January 25, 2005; 102(4): 1127 - 1132. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Matsumoto, E. Kubota, Y. Omi, U. Lee, and J. M. Penninger Essential Role of LFA-1 in Activating Th2-Like Responses by {alpha}-Galactosylceramide-Activated NKT Cells J. Immunol., October 15, 2004; 173(8): 4976 - 4984. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Amprey, J. S. Im, S. J. Turco, H. W. Murray, P. A. Illarionov, G. S. Besra, S. A. Porcelli, and G. F. Spath A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan J. Exp. Med., October 4, 2004; 200(7): 895 - 904. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. V. Parekh, A. K. Singh, M. T. Wilson, D. Olivares-Villagomez, J. S. Bezbradica, H. Inazawa, H. Ehara, T. Sakai, I. Serizawa, L. Wu, et al. Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct {alpha}- and {beta}-Anomeric Glycolipids J. Immunol., September 15, 2004; 173(6): 3693 - 3706. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Sidobre, K. J. L. Hammond, L. Benazet-Sidobre, S. D. Maltsev, S. K. Richardson, R. M. Ndonye, A. R. Howell, T. Sakai, G. S. Besra, S. A. Porcelli, et al. The T cell antigen receptor expressed by V{alpha}14i NKT cells has a unique mode of glycosphingolipid antigen recognition PNAS, August 17, 2004; 101(33): 12254 - 12259. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Adachi, H. Tsutsui, E. Seki, H. Nakano, K. Takeda, K. Okumura, L. Van Kaer, and K. Nakanishi Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice Int. Immunol., June 1, 2004; 16(6): 787 - 798. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. M. S. Huang, P. Borszcz, S. Sidobre, M. Kronenberg, and K. P. Kane CD1d1 Displayed on Cell Size Beads Identifies and Enriches an NK Cell Population Negatively Regulated by CD1d1 J. Immunol., May 1, 2004; 172(9): 5304 - 5312. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Yamanaka, S. Hamano, Y. Miyazaki, K. Ishii, A. Takeda, T. W. Mak, K. Himeno, A. Yoshimura, and H. Yoshida Hyperproduction of Proinflammatory Cytokines by WSX-1-Deficient NKT Cells in Concanavalin A-Induced Hepatitis J. Immunol., March 15, 2004; 172(6): 3590 - 3596. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Yang, A. Ueno, M. Bao, Z. Wang, J. S. Im, S. Porcelli, and J.-W. Yoon Control of NKT Cell Differentiation by Tissue-Specific Microenvironments J. Immunol., December 1, 2003; 171(11): 5913 - 5920. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Rauch, J. Gumperz, C. Robinson, M. Skold, C. Roy, D. C. Young, M. Lafleur, D. B. Moody, M. B. Brenner, C. E. Costello, et al. Structural Features of the Acyl Chain Determine Self-phospholipid Antigen Recognition by a CD1d-restricted Invariant NKT (iNKT) Cell J. Biol. Chem., November 28, 2003; 278(48): 47508 - 47515. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. F. Hermans, J. D. Silk, U. Gileadi, M. Salio, B. Mathew, G. Ritter, R. Schmidt, A. L. Harris, L. Old, and V. Cerundolo NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells J. Immunol., November 15, 2003; 171(10): 5140 - 5147. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. K. Stanic, R. Shashidharamurthy, J. S. Bezbradica, N. Matsuki, Y. Yoshimura, S. Miyake, E. Y. Choi, T. D. Schell, L. Van Kaer, S. S. Tevethia, et al. Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR J. Immunol., November 1, 2003; 171(9): 4539 - 4551. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Elewaut, A. P. Lawton, N. A. Nagarajan, E. Maverakis, A. Khurana, S. Honing, C. A. Benedict, E. Sercarz, O. Bakke, M. Kronenberg, et al. The Adaptor Protein AP-3 Is Required for CD1d-Mediated Antigen Presentation of Glycosphingolipids and Development of V{alpha}14i NKT Cells J. Exp. Med., October 20, 2003; 198(8): 1133 - 1146. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Y. Crowe, A. P. Uldrich, K. Kyparissoudis, K. J. L. Hammond, Y. Hayakawa, S. Sidobre, R. Keating, M. Kronenberg, M. J. Smyth, and D. I. Godfrey Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells J. Immunol., October 15, 2003; 171(8): 4020 - 4027. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Skold and S. M. Behar Role of CD1d-Restricted NKT Cells in Microbial Immunity Infect. Immun., October 1, 2003; 71(10): 5447 - 5455. [Full Text] [PDF] |
||||
![]() |
J. L. Matsuda, L. Gapin, J. L. Baron, S. Sidobre, D. B. Stetson, M. Mohrs, R. M. Locksley, and M. Kronenberg Mouse V{alpha}14i natural killer T cells are resistant to cytokine polarization in vivo PNAS, July 8, 2003; 100(14): 8395 - 8400. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Y. Wu, N. H. Segal, S. Sidobre, M. Kronenberg, and P. B. Chapman Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells J. Exp. Med., July 7, 2003; 198(1): 173 - 181. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Sivakumar, K. J.L. Hammond, N. Howells, K. Pfeffer, and F. Weih Differential Requirement for Rel/Nuclear Factor {kappa}B Family Members in Natural Killer T Cell Development J. Exp. Med., June 16, 2003; 197(12): 1613 - 1621. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Elewaut, R. B. Shaikh, K. J. L. Hammond, H. De Winter, A. J. Leishman, S. Sidobre, O. Turovskaya, T. I. Prigozy, L. Ma, T. A. Banks, et al. NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of V{alpha}14i NKT Cells J. Exp. Med., June 16, 2003; 197(12): 1623 - 1633. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Schumann, R. B. Voyle, B.-Y. Wei, and H. R. MacDonald Cutting Edge: Influence of the TCR V{beta} Domain on the Avidity of CD1d:{alpha}-Galactosylceramide Binding by Invariant V{alpha}14 NKT Cells J. Immunol., June 15, 2003; 170(12): 5815 - 5819. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. H. Robbins, S. C. Terrizzi, B. C. Sydora, T. Mikayama, and L. Brossay Differential Regulation of Killer Cell Lectin-Like Receptor G1 Expression on T Cells J. Immunol., June 15, 2003; 170(12): 5876 - 5885. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Capone, D. Cantarella, J. Schumann, O. V. Naidenko, C. Garavaglia, F. Beermann, M. Kronenberg, P. Dellabona, H. R. MacDonald, and G. Casorati Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice J. Immunol., March 1, 2003; 170(5): 2390 - 2398. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. K. Stanic, A. D. De Silva, J.-J. Park, V. Sriram, S. Ichikawa, Y. Hirabyashi, K. Hayakawa, L. Van Kaer, R. R. Brutkiewicz, and S. Joyce Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta -D-glucosylceramide synthase deficiency PNAS, February 18, 2003; 100(4): 1849 - 1854. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. L. H. van Dommelen, H. A. Tabarias, M. J. Smyth, and M. A. Degli-Esposti Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection Enhances the Antiviral Response Mediated by NK Cells J. Virol., February 1, 2003; 77(3): 1877 - 1884. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-J. Kang and P. Cresswell Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain J. Biol. Chem., November 15, 2002; 277(47): 44838 - 44844. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Chackerian, J. Alt, V. Perera, and S. M. Behar Activation of NKT Cells Protects Mice from Tuberculosis Infect. Immun., November 1, 2002; 70(11): 6302 - 6309. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Oikawa, A. Shimada, S. Yamada, Y. Motohashi, Y. Nakagawa, J.-i. Irie, T. Maruyama, and T. Saruta High Frequency of V{alpha}24+ V{beta}11+ T-Cells Observed in Type 1 Diabetes Diabetes Care, October 1, 2002; 25(10): 1818 - 1823. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. O. Procopio, I. C. Almeida, A. C. T. Torrecilhas, J. E. Cardoso, L. Teyton, L. R. Travassos, A. Bendelac, and R. T. Gazzinelli Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins from Trypanosoma cruzi Bind to CD1d but Do Not Elicit Dominant Innate or Adaptive Immune Responses Via the CD1d/NKT Cell Pathway J. Immunol., October 1, 2002; 169(7): 3926 - 3933. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. S. Davis, H. Li, C.-C. Chen, Y.-H. Wang, M. D. Cooper, and P. D. Burrows Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells Int. Immunol., September 1, 2002; 14(9): 1075 - 1083. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Hayakawa, K. Takeda, H. Yagita, M. J. Smyth, L. Van Kaer, K. Okumura, and I. Saiki IFN-gamma -mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha -galactosylceramide Blood, August 13, 2002; 100(5): 1728 - 1733. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Sidobre, O. V. Naidenko, B.-C. Sim, N. R. J. Gascoigne, K. C. Garcia, and M. Kronenberg The V{alpha}14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex J. Immunol., August 1, 2002; 169(3): 1340 - 1348. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Sriram, S. Cho, P. Li, P. W. O'Donnell, C. Dunn, K. Hayakawa, J. S. Blum, and R. R. Brutkiewicz Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells PNAS, June 11, 2002; 99(12): 8197 - 8202. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. J. Roberts, V. Sriram, P. M. Spence, M. Gui, K. Hayakawa, I. Bacik, J. R. Bennink, J. W. Yewdell, and R. R. Brutkiewicz Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells J. Immunol., June 1, 2002; 168(11): 5409 - 5414. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Balmer and E. Devaney NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi Infect. Immun., April 1, 2002; 70(4): 2215 - 2219. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. R. Johnson, S. Hong, L. Van Kaer, Y. Koezuka, and B. S. Graham NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus J. Virol., March 27, 2002; 76(9): 4294 - 4303. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. J. Smyth, N. Y. Crowe, D. G. Pellicci, K. Kyparissoudis, J. M. Kelly, K. Takeda, H. Yagita, and D. I. Godfrey Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramide Blood, February 15, 2002; 99(4): 1259 - 1266. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. D. De Silva, J.-J. Park, N. Matsuki, A. K. Stanic, R. R. Brutkiewicz, M. E. Medof, and S. Joyce Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum J. Immunol., January 15, 2002; 168(2): 723 - 733. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Mempel, C. Ronet, F. Suarez, M. Gilleron, G. Puzo, L. Van Kaer, A. Lehuen, P. Kourilsky, and G. Gachelin Natural Killer T Cells Restricted by the Monomorphic MHC Class 1b CD1d1 Molecules Behave Like Inflammatory Cells J. Immunol., January 1, 2002; 168(1): 365 - 371. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis J. Exp. Med., December 17, 2001; 194(12): 1801 - 1811. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Gui, J. Li, L.-J. Wen, R. R. Hardy, and K. Hayakawa TCR{beta} Chain Influences But Does Not Solely Control Autoreactivity of V{alpha}14J281T Cells J. Immunol., December 1, 2001; 167(11): 6239 - 6246. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kawakami, Y. Kinjo, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Nakayama, M. Taniguchi, and A. Saito Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection J. Immunol., December 1, 2001; 167(11): 6525 - 6532. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Hobbs, S. Cho, T. J. Roberts, V. Sriram, J. Zhang, M. Xu, and R. R. Brutkiewicz Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus J. Virol., November 15, 2001; 75(22): 10746 - 10754. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Ikarashi, R. Mikami, A. Bendelac, M. Terme, N. Chaput, M. Terada, T. Tursz, E. Angevin, F. A. Lemonnier, H. Wakasugi, et al. Dendritic Cell Maturation Overrules H-2d-Mediated Natural Killer T (Nkt) Cell Inhibition: Critical Role for B7 in Cd1d-Dependent Nkt Cell Interferon {gamma} Production J. Exp. Med., October 15, 2001; 194(8): 1179 - 1186. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. S. Metelitsa, O. V. Naidenko, A. Kant, H.-W. Wu, M. J. Loza, B. Perussia, M. Kronenberg, and R. C. Seeger Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells J. Immunol., September 15, 2001; 167(6): 3114 - 3122. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Trobonjaca, F. Leithauser, P. Moller, R. Schirmbeck, and J. Reimann Activating Immunity in the Liver. I. Liver Dendritic Cells (but Not Hepatocytes) Are Potent Activators of IFN-{gamma} Release by Liver NKT Cells J. Immunol., August 1, 2001; 167(3): 1413 - 1422. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Kamada, H. Iijima, K. Kimura, M. Harada, E. Shimizu, S.-i. Motohashi, T. Kawano, H. Shinkai, T. Nakayama, T. Sakai, et al. Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to V{{alpha}}14 NKT cells Int. Immunol., July 1, 2001; 13(7): 853 - 861. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Hayakawa, K. Takeda, H. Yagita, L. Van Kaer, I. Saiki, and K. Okumura Differential Regulation of Th1 and Th2 Functions of NKT Cells by CD28 and CD40 Costimulatory Pathways J. Immunol., May 15, 2001; 166(10): 6012 - 6018. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Shiina, A. Ando, Y. Suto, F. Kasai, A. Shigenari, N. Takishima, E. Kikkawa, K. Iwata, Y. Kuwano, Y. Kitamura, et al. Genomic Anatomy of a Premier Major Histocompatibility Complex Paralogous Region on Chromosome 1q21-q22 Genome Res., May 1, 2001; 11(5): 789 - 802. [Abstract] [Full Text] |
||||
![]() |
S.-H. Park, A. Weiss, K. Benlagha, T. Kyin, L. Teyton, and A. Bendelac The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families J. Exp. Med., April 16, 2001; 193(8): 893 - 904. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. J. Smyth, E. Cretney, K. Takeda, R. H. Wiltrout, L. M. Sedger, N. Kayagaki, H. Yagita, and K. Okumura Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon {gamma}-Dependent Natural Killer Cell Protection from Tumor Metastasis J. Exp. Med., March 19, 2001; 193(6): 661 - 670. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Laloux, L. Beaudoin, D. Jeske, C. Carnaud, and A. Lehuen NK T Cell-Induced Protection Against Diabetes in V{{alpha}}14-J{{alpha}}281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen J. Immunol., March 15, 2001; 166(6): 3749 - 3756. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Trobonjaca, F. Leithauser, P. Moller, H. Bluethmann, Y. Koezuka, H. R. MacDonald, and J. Reimann MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG-/- Hosts J. Immunol., March 15, 2001; 166(6): 3804 - 3812. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kronenberg, O. Naidenko, and F. Koning Right on target: Novel approaches for the direct visualization of CD1-specific T cell responses PNAS, March 13, 2001; 98(6): 2950 - 2952. [Full Text] [PDF] |
||||
![]() |
M. del C. Salamone, G. A. Rabinovich, A. K. Mendiguren, G. V. Salamone, and L. Fainboim Activation-induced expression of CD1d antigen on mature T cells J. Leukoc. Biol., February 1, 2001; 69(2): 207 - 214. [Abstract] [Full Text] |
||||
![]() |
C. Ronet, M. Mempel, N. Thieblemont, A. Lehuen, P. Kourilsky, and G. Gachelin Role of the Complementarity-Determining Region 3 (CDR3) of the TCR-{{beta}} Chains Associated with the V{{alpha}}14 Semi-Invariant TCR {{alpha}}-Chain in the Selection of CD4+ NK T Cells J. Immunol., February 1, 2001; 166(3): 1755 - 1762. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. I. Prigozy, O. Naidenko, P. Qasba, D. Elewaut, L. Brossay, A. Khurana, T. Natori, Y. Koezuka, A. Kulkarni, and M. Kronenberg Glycolipid Antigen Processing for Presentation by CD1d Molecules Science, January 26, 2001; 291(5504): 664 - 667. [Abstract] [Full Text] |
||||
![]() |
M. C. Leite-de-Moraes, A. Hameg, M. Pacilio, Y. Koezuka, M. Taniguchi, L. Van Kaer, E. Schneider, M. Dy, and A. Herbelin IL-18 Enhances IL-4 Production by Ligand-Activated NKT Lymphocytes: A Pro-Th2 Effect of IL-18 Exerted Through NKT Cells J. Immunol., January 15, 2001; 166(2): 945 - 951. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Pal, T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of V{{alpha}}14 NK T Cells J. Immunol., January 1, 2001; 166(1): 662 - 668. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. J. Andrews, A. Ribas, L. H. Butterfield, C. M. Vollmer, F. C. Eilber, V. B. Dissette, S. D. Nelson, P. Shintaku, S. Mekhoubad, T. Nakayama, et al. Adenovirus-Interleukin-12-mediated Tumor Regression in a Murine Hepatocellular Carcinoma Model Is Not Dependent on CD1-restricted Natural Killer T Cells Cancer Res., November 1, 2000; 60(22): 6457 - 6464. [Abstract] [Full Text] |
||||
![]() |
L. M. Araujo, A. Puel, C. Gouarin, A. Hameg, J.-C. Mevel, Y. Koezuka, J.-F. Bach, D. Mouton, and A. Herbelin NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes Int. Immunol., November 1, 2000; 12(11): 1613 - 1622. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Hameg, I. Apostolou, M. Leite-de-Moraes, J.-M. Gombert, C. Garcia, Y. Koezuka, J.-F. Bach, and A. Herbelin A Subset of NKT Cells That Lacks the NK1.1 Marker, Expresses CD1d Molecules, and Autopresents the {alpha}-Galactosylceramide Antigen J. Immunol., November 1, 2000; 165(9): 4917 - 4926. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Leite-de-Moraes, A. Herbelin, C. Gouarin, Y. Koezuka, E. Schneider, and M. Dy Fas/Fas Ligand Interactions Promote Activation-Induced Cell Death of NK T Lymphocytes J. Immunol., October 15, 2000; 165(8): 4367 - 4371. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kakimi, L. G. Guidotti, Y. Koezuka, and F. V. Chisari Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo J. Exp. Med., October 2, 2000; 192(7): 921 - 930. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Bonish, D. Jullien, Y. Dutronc, B. B. Huang, R. Modlin, F. M. Spada, S. A. Porcelli, and B. J. Nickoloff Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-{gamma} Production by NK-T Cells J. Immunol., October 1, 2000; 165(7): 4076 - 4085. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Matsuda, O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C.-R. Wang, Y. Koezuka, and M. Kronenberg Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers J. Exp. Med., September 5, 2000; 192(5): 741 - 754. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Apostolou, A. Cumano, G. Gachelin, and P. Kourilsky Evidence for Two Subgroups of CD4-CD8- NKT Cells with Distinct TCR{alpha}{beta} Repertoires and Differential Distribution in Lymphoid Tissues J. Immunol., September 1, 2000; 165(5): 2481 - 2490. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Burdin, L. Brossay, M. Degano, H. Iijima, M. Gui, I. A. Wilson, and M. Kronenberg Structural requirements for antigen presentation by mouse CD1 PNAS, August 29, 2000; 97(18): 10156 - 10161. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ishihara, M. Nieda, J. Kitayama, T. Osada, T. Yabe, A. Kikuchi, Y. Koezuka, S. A. Porcelli, K. Tadokoro, H. Nagawa, et al. {alpha}-Glycosylceramides Enhance the Antitumor Cytotoxicity of Hepatic Lymphocytes Obtained from Cancer Patients by Activating CD3-CD56+ NK Cells In Vitro J. Immunol., August 1, 2000; 165(3): 1659 - 1664. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |