HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Frenkel, S. Articles by Razin, E. Search for Related Content PubMed PubMed Citation Articles by Frenkel, S. Articles by Razin, E.

Nuclear Translocation of Upstream Stimulating Factor 2 (USF2) in Activated Mast Cells: A Possible Role in Their Survival¹

Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Multiple transcription factors are activated in the cytoplasm and translocated to the nucleus where they exert positive or negative control over cellular genes. Such subcellular traffic of transcription factors usually requires the presence of a positively charged nuclear localization sequence (NLS). Upstream stimulating factor 2 (USF2) is one of the few transcription factors that contain two potential domains for nuclear localization. In addition to the conventional basic NLS, USF2 contains a highly conserved USF-specific region that is involved in its nuclear translocation. In the present work, the induction of translocation of USF2 into the mast cell nucleus was observed and found to be dependent on activation of the cells either by IL-3 or IgE-Ag. It was also observed that the prevention of the translocation of USF2 to the nucleus, using a peptide derived from the specific USF-NLS region, significantly inhibited their IL-3-mediated survival. Thus, our findings show a direct connection between mast cell surface receptor-mediated USF2 nuclear translocation and cell viability.

This article has been cited by other articles:

				K.-Y. Park and A. F. Russo Control of the Calcitonin Gene-related Peptide Enhancer by Upstream Stimulatory Factor in Trigeminal Ganglion Neurons J. Biol. Chem., February 29, 2008; 283(9): 5441 - 5451. [Abstract] [Full Text] [PDF]

				Y.-N. Lee and E. Razin Nonconventional Involvement of LysRS in the Molecular Mechanism of USF2 Transcriptional Activity in Fc{varepsilon}RI-Activated Mast Cells Mol. Cell. Biol., October 15, 2005; 25(20): 8904 - 8912. [Abstract] [Full Text] [PDF]

				W. G. Chen, A. E. West, X. Tao, G. Corfas, M. N. Szentirmay, M. Sawadogo, C. Vinson, and M. E. Greenberg Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons J. Neurosci., April 1, 2003; 23(7): 2572 - 2581. [Abstract] [Full Text] [PDF]

				Y. Fei and T. E. Hughes Nuclear Trafficking of Photoreceptor Protein Crx: The Targeting Sequence and Pathologic Implications Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 2849 - 2856. [Abstract] [Full Text]