| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RIIB1 Activates Src Homology 2-Containing Protein Tyrosine Phosphatase-11
The John P. Robarts Research Institute and Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
Fc
RIIB1 (CD32) is a receptor that binds the Fc domain of
Ag-complexed IgG. Coaggregation of B cell receptor (BCR) and FcRIIB1
generates a dominant negative signal that inhibits B cell activation.
In Ag-specific Id-positive B cells, the co-cross-linking of BCR and
FcRIIB1 by anti-Id Ab resulted in the association of both Src
homology 2-containing protein tyrosine phosphatase (SHP-1) and Src
homology 2-containing inositol phosphatase (SHIP) with the FcRIIB1;
however, only SHIP activity was detected. "Superclustering" of the
BCR and FcRIIB1 complex induced by stimulation with anti-Id Ab
plus polyvalent Ag synergistically activated SHP-1. The degree of
co-cross-linking between BCR and FcRIIB1 may determine the
activation status of SHP-1 and SHIP.
This article has been cited by other articles:
|
|
 |
|
  A. R. Crow, S. Song, J. Freedman, C. D. Helgason, R. K. Humphries, K. A. Siminovitch, and A. H. Lazarus IVIg-mediated amelioration of murine ITP via Fc{gamma}RIIB is independent of SHIP1, SHP-1, and Btk activity Blood, July 15, 2003; 102(2): 558 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brauweiler, I. Tamir, S. Marschner, C. D. Helgason, and J. C. Cambier Partially Distinct Molecular Mechanisms Mediate Inhibitory Fc{{gamma}}RIIB Signaling in Resting and Activated B Cells J. Immunol., July 1, 2001; 167(1): 204 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages Int. Immunol., February 1, 2001; 13(2): 167 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Fong, A. Brauweiler, S. A. Minskoff, P. Bruhns, I. Tamir, I. Mellman, M. Daeron, and J. C. Cambier Mutational Analysis Reveals Multiple Distinct Sites Within Fc{gamma} Receptor IIB That Function in Inhibitory Signaling J. Immunol., October 15, 2000; 165(8): 4453 - 4462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura, A. Brauweiler, and J. C. Cambier Effects of Src Homology Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on Fc{gamma}RIIB1-Effector Interactions and Inhibitory Functions J. Immunol., January 15, 2000; 164(2): 631 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Nagayama, and T. A. Takahashi Aberrant CD3- and CD28-Mediated Signaling Events in Cord Blood T Cells Are Associated with Dysfunctional Regulation of Fas Ligand-Mediated Cytotoxicity J. Immunol., April 15, 1999; 162(8): 4464 - 4471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Nagayama, K. Tadokoro, T. Juji, and T. A. Takahashi Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapk Are Involved in IL-10-Mediated Selective Repression of TNF-{alpha}-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells J. Immunol., April 1, 1999; 162(7): 3865 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.C. FONG and J.C. CAMBIER Inhibitory Receptors and Their Modes of Action Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 329 - 334. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Bruhns, F. Vely, O. Malbec, W. H. Fridman, E. Vivier, and M. Daeron Molecular Basis of the Recruitment of the SH2 Domain-containing Inositol 5-Phosphatases SHIP1 and SHIP2 by Fcgamma RIIB J. Biol. Chem., November 22, 2000; 275(48): 37357 - 37364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lesourne, P. Bruhns, W. H. Fridman, and M. Daeron Insufficient Phosphorylation Prevents Fcgamma RIIB from Recruiting the SH2 Domain-containing Protein-tyrosine Phosphatase SHP-1 J. Biol. Chem., February 23, 2001; 276(9): 6327 - 6336. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
