| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases,
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, and the
Immunology Service, Clinical Center, National Institutes of Health, Bethesda, MD 20892
IL-12 and IL-10, respectively, stimulate Th1 and Th2 immune responses. The development of some allergic reactions, infections, and tumors are associated with excessive histamine production and a shift toward Th2 responses. Here we address the possibility that this association is causally linked, at least in part, to modulation of IL-12 and IL-10 production by histamine. We report that histamine dose-dependently inhibited the secretion of human IL-12 (p70) and increased the production of IL-10 in LPS-stimulated whole blood cultures. These effects of histamine were antagonized by cimetidine, an H2 receptor antagonist, but not by selective H1 and H3 receptor blockers, and were mimicked by an H2 receptor agonist. The effects of histamine on IL-12 and IL-10 secretion were independent of endogenous secretion of IL-10 or exogenous addition of IL-12, while Ro 20–1724, a phosphodiesterase inhibitor, potentiated the effects of histamine on IL-12 and IL-10 production, implicating cAMP in its actions. Similar modulatory effects of histamine on IL-12 and IL-10 production, which were reversed by the H2 antagonist cimetidine, were observed in PBMC and isolated monocytes stimulated by Staphylococcus aureus Cowan strain 1 and LPS, respectively. Thus, histamine, via stimulation of H2 receptors on peripheral monocytes and subsequent elevation of cAMP, suppresses IL-12 and stimulates IL-10 secretion, changes that may result in a shift of Th1/Th2 balance toward Th2-dominance. This may represent a novel mechanism by which excessive secretion of histamine potentiates Th2-mediated allergic reactions and contributes to the development of certain infections and tumors normally eliminated by Th1-dependent immune mechanisms.
This article has been cited by other articles:
|
|
 |
|
  I. J. Elenkov, R. Kvetnansky, A. Hashiramoto, V. K. Bakalov, A. A. Link, K. Zachman, M. Crane, D. Jezova, J. Rovensky, M. A. Dimitrov, et al. Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans? J. Immunol., August 1, 2008; 181(3): 1737 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Beghdadi, A. Porcherie, B. S. Schneider, D. Dubayle, R. Peronet, M. Huerre, T. Watanabe, H. Ohtsu, J. Louis, and S. Mecheri Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease J. Exp. Med., February 18, 2008; 205(2): 395 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Tan, S. Essengue, J. Talreja, J. Reese, D. J. Stechschulte, and K. N. Dileepan Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells J. Immunol., December 1, 2007; 179(11): 7899 - 7906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Polumuri, V. Y. Toshchakov, and S. N. Vogel Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fc{gamma} Receptor Ligation in Murine Macrophages J. Immunol., July 1, 2007; 179(1): 236 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E Fit and P. C Williams Use of Histamine2-Antagonists for the Treatment of Verruca Vulgaris Ann. Pharmacother., July 1, 2007; 41(7): 1222 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Depinay, F. Hacini, W. Beghdadi, R. Peronet, and S. Mecheri Mast Cell-Dependent Down-Regulation of Antigen-Specific Immune Responses by Mosquito Bites J. Immunol., April 1, 2006; 176(7): 4141 - 4146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Musio, B. Gallo, S. Scabeni, M. Lapilla, P. L. Poliani, G. Matarese, H. Ohtsu, S. J. Galli, R. Mantegazza, L. Steinman, et al. A Key Regulatory Role for Histamine in Experimental Autoimmune Encephalomyelitis: Disease Exacerbation in Histidine Decarboxylase-Deficient Mice J. Immunol., January 1, 2006; 176(1): 17 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Masaki, S. Chiba, H. Tatsukawa, H. Noguchi, T. Kakuma, M. Endo, M. Seike, T. Watanabe, and H. Yoshimatsu The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury FASEB J, August 1, 2005; 19(10): 1245 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gutzmer, C. Diestel, S. Mommert, B. Kother, H. Stark, M. Wittmann, and T. Werfel Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells J. Immunol., May 1, 2005; 174(9): 5224 - 5232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Munford Invited review: Detoxifying endotoxin: time, place and person Innate Immunity, April 1, 2005; 11(2): 69 - 84. [Abstract] [PDF]
|
|
|
|
|
|
S.-W. Qiao, J. Piper, G. Haraldsen, I. Oynebraten, B. Fleckenstein, O. Molberg, C. Khosla, and L. M. Sollid Tissue Transglutaminase-Mediated Formation and Cleavage of Histamine-Gliadin Complexes: Biological Effects and Implications for Celiac Disease J. Immunol., February 1, 2005; 174(3): 1657 - 1663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nemmar, P. H.M. Hoet, J. Vermylen, B. Nemery, and M. F. Hoylaerts Pharmacological Stabilization of Mast Cells Abrogates Late Thrombotic Events Induced by Diesel Exhaust Particles in Hamsters Circulation, September 21, 2004; 110(12): 1670 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Couillin, I. Maillet, B. B. Vargaftig, M. Jacobs, G. C. Paesen, P. A. Nuttall, J. Lefort, R. Moser, W. Weston-Davies, and B. Ryffel Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma J. Immunol., September 1, 2004; 173(5): 3281 - 3286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Schneider, M.-B. Tonanny, M. Lisbonne, M. Leite-de-Moraes, and M. Dy Pro-Th1 Cytokines Promote Fas-Dependent Apoptosis of Immature Peripheral Basophils J. Immunol., May 1, 2004; 172(9): 5262 - 5268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Teuscher, M. E. Poynter, H. Offner, A. Zamora, T. Watanabe, P. D. Fillmore, J. F. Zachary, and E. P. Blankenhorn Attenuation of Th1 Effector Cell Responses and Susceptibility to Experimental Allergic Encephalomyelitis in Histamine H2 Receptor Knockout Mice Is Due to Dysregulation of Cytokine Production by Antigen-Presenting Cells Am. J. Pathol., March 1, 2004; 164(3): 883 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Morrison, C. B. Wilson, M. Ray, and P. H. Correll Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-{gamma} and Lipopolysaccharide J. Immunol., February 1, 2004; 172(3): 1825 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Diks, J. C. Hardwick, R. M. Diab, M. M. van Santen, H. H. Versteeg, S. J. H. van Deventer, D. J. Richel, and M. P. Peppelenbosch Activation of the Canonical {beta}-Catenin Pathway by Histamine J. Biol. Chem., December 26, 2003; 278(52): 52491 - 52496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Masci, M. Galgani, S. Cassano, S. De Simone, A. Gallo, V. De Rosa, S. Zappacosta, and L. Racioppi HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling J. Leukoc. Biol., December 1, 2003; 74(6): 1117 - 1124. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. A. Holly and P. M. Bracci Population-based Study of Non-Hodgkin Lymphoma, Histology, and Medical History among Human Immunodeficiency Virus-negative Participants in San Francisco Am. J. Epidemiol., August 15, 2003; 158(4): 316 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Munoz, R. Hernandez-Pando, S. N. Abraham, and J. A. Enciso Mast Cell Activation by Mycobacterium tuberculosis: Mediator Release and Role of CD48 J. Immunol., June 1, 2003; 170(11): 5590 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Morichika, H. K. Takahashi, H. Iwagaki, T. Yoshino, R. Tamura, M. Yokoyama, S. Mori, T. Akagi, M. Nishibori, and N. Tanaka Histamine Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-{alpha} Production in an Intercellular Adhesion Molecule-1- and B7.1-Dependent Manner J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 624 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kuroda and U. Yamashita Mechanisms of Enhanced Macrophage-Mediated Prostaglandin E2 Production and Its Suppressive Role in Th1 Activation in Th2-Dominant BALB/c Mice J. Immunol., January 15, 2003; 170(2): 757 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Upham, P. T. Lee, B. J. Holt, T. Heaton, S. L. Prescott, M. J. Sharp, P. D. Sly, and P. G. Holt Development of Interleukin-12-Producing Capacity throughout Childhood Infect. Immun., December 1, 2002; 70(12): 6583 - 6588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vigano, E. Somigliana, S. Mangioni, M. Vignali, M. Vignali, and A. M. Di Blasio Expression of Interleukin-10 and Its Receptor Is Up-Regulated in Early Pregnant Versus Cycling Human Endometrium J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5730 - 5736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gantner, K. Sakai, M. W. Tusche, W. W. Cruikshank, D. M. Center, and K. B. Bacon Histamine H4 and H2 Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8+ T Cells J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 300 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Suarez, L. Mozo, and C. Gutierrez Generation of CD4+CD45RA+ Effector T Cells by Stimulation in the Presence of Cyclic Adenosine 5'-Monophosphate- Elevating Agents J. Immunol., August 1, 2002; 169(3): 1159 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Czuprynski, N. G. Faith, and H. Steinberg Ability of the Listeria monocytogenes Strain Scott A To Cause Systemic Infection in Mice Infected by the Intragastric Route Appl. Envir. Microbiol., June 1, 2002; 68(6): 2893 - 2900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Takahashi, H. Iwagaki, T. Yoshino, S. Mori, T. Morichika, H. Itoh, M. Yokoyama, S. Kubo, E. Kondo, T. Akagi, et al. Prostaglandin E2 Inhibits IL-18-Induced ICAM-1 and B7.2 Expression Through EP2/EP4 Receptors in Human Peripheral Blood Mononuclear Cells J. Immunol., May 1, 2002; 168(9): 4446 - 4454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wittmann, P. Kienlin, S. Mommert, A. Kapp, and T. Werfel Suppression of IL-12 Production by Soluble CD40 Ligand: Evidence for Involvement of the p44/42 Mitogen-Activated Protein Kinase Pathway J. Immunol., April 15, 2002; 168(8): 3793 - 3800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Czuprynski and N. G. Faith Sodium Bicarbonate Enhances the Severity of Infection in Neutropenic Mice Orally Inoculated with Listeria monocytogenes EGD Clin. Vaccine Immunol., March 1, 2002; 9(2): 477 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Takahashi, A. Yoshida, H. Iwagaki, T. Yoshino, H. Itoh, T. Morichika, M. Yokoyama, T. Akagi, N. Tanaka, S. Mori, et al. Histamine Regulation of Interleukin-18-Initiating Cytokine Cascade Is Associated with Down-Regulation of Intercellular Adhesion Molecule-1 Expression in Human Peripheral Blood Mononuclear Cells J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 227 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Elenkov, R. L. Wilder, V. K. Bakalov, A. A. Link, M. A. Dimitrov, S. Fisher, M. Crane, K. S. Kanik, and G. P. Chrousos IL-12, TNF-{alpha}, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4933 - 4938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caron, Y. Delneste, E. Roelandts, C. Duez, J.-Y. Bonnefoy, J. Pestel, and P. Jeannin Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells J. Immunol., October 1, 2001; 167(7): 3682 - 3686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Fleming, H. He, A. Ciota, D. Perkins, and P. W. Finn Administration of Pentoxifylline During Allergen Sensitization Dissociates Pulmonary Allergic Inflammation from Airway Hyperresponsiveness J. Immunol., August 1, 2001; 167(3): 1703 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Caron, Y. Delneste, E. Roelandts, C. Duez, N. Herbault, G. Magistrelli, J.-Y. Bonnefoy, J. Pestel, and P. Jeannin Histamine Induces CD86 Expression and Chemokine Production by Human Immature Dendritic Cells J. Immunol., May 15, 2001; 166(10): 6000 - 6006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Triggiani, M. Gentile, A. Secondo, F. Granata, A. Oriente, M. Taglialatela, L. Annunziato, and G. Marone Histamine Induces Exocytosis and IL-6 Production from Human Lung Macrophages Through Interaction with H1 Receptors J. Immunol., March 15, 2001; 166(6): 4083 - 4091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System Pharmacol. Rev., December 1, 2000; 52(4): 595 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Klein, C. A. Newton, N. Nakachi, and H. Friedman {Delta}9-Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-{gamma}, IL-12, and IL-12 Receptor {beta}2 Responses to Legionella pneumophila Infection J. Immunol., June 15, 2000; 164(12): 6461 - 6466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kohka, M. Nishibori, H. Iwagaki, N. Nakaya, T. Yoshino, K. Kobashi, K. Saeki, N. Tanaka, and T. Akagi Histamine Is a Potent Inducer of IL-18 and IFN-{gamma} in Human Peripheral Blood Mononuclear Cells J. Immunol., June 15, 2000; 164(12): 6640 - 6646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. BONT, C. J. HEIJNEN, A. KAVELAARS, W. M. C. van AALDEREN, F. BRUS, J. Th. M. DRAAISMA, S. M. GEELEN, and J. L. L. KIMPEN Monocyte IL-10 Production during Respiratory Syncytial Virus Bronchiolitis Is Associated with Recurrent Wheezing in a One-Year Follow-up Study Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1518 - 1523. [Abstract] [Full Text]
|
|
|
|
|
|
J. Sirois, G. Menard, A. S. Moses, and E. Y. Bissonnette Importance of Histamine in the Cytokine Network in the Lung Through H2 and H3 Receptors: Stimulation of IL-10 Production J. Immunol., March 15, 2000; 164(6): 2964 - 2970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wessler, M. Hocker, W. Fischer, T. C. Wang, S. Rosewicz, R. Haas, B. Wiedenmann, T. F. Meyer, and M. Naumann Helicobacter pylori Activates the Histidine Decarboxylase Promoter through a Mitogen-activated Protein Kinase Pathway Independent of Pathogenicity Island-encoded Virulence Factors J. Biol. Chem., February 4, 2000; 275(5): 3629 - 3636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Link, T. Kino, J. A. Worth, J. L. McGuire, M. L. Crane, G. P. Chrousos, R. L. Wilder, and I. J. Elenkov Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes J. Immunol., January 1, 2000; 164(1): 436 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Banu and T. Watanabe Augmentation of Antigen Receptor-mediated Responses by Histamine H1 Receptor Signaling J. Exp. Med., February 15, 1999; 189(4): 673 - 682. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
