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*
Institut National de la Santé et de la Recherche Médicale, Unit 90 and Department of Nephrology, Necker Hospital, Paris, France;
University Hospitals, Cleveland, OH 44106;
Centre National de la Recherche Scientifique, Unité de Recherche Associée 400, Paris, France; and
§
Division of Immunology and Allergy, University Hospital, Geneva, Switzerland
We previously demonstrated the presence of advanced oxidation
protein products (AOPP), a novel marker of oxidative stress in the
plasma of uremic patients receiving maintenance dialysis. The present
study in a cohort of 162 uremic patients showed that plasma
concentrations of AOPP increased with progression of chronic renal
failure and were closely related to advanced glycation end products
(AGE)-pentosidine (r = 0.52, p
< 0.001), taken as a marker of AGE. In vivo, the relevance of AOPP and
AGE-pentosidine in monocyte-mediated inflammatory syndrome associated
with uremia was evidenced by close correlations between AOPP or
AGE-pentosidine and monocyte activation markers, including neopterin,
IL-1R antagonist, TNF-
, and TNF soluble receptors (TNF-sR55 and
TNF-sR75). To determine the mechanisms by which AOPP and AGE could be
directly involved in monocyte activation, AOPP-human serum albumin
(HSA) and AGE-HSA were produced in vitro by treating HSA with oxidants
or glucose, respectively. Spectroscopic analysis confirmed that
AOPP-HSA contains carbonyls and dityrosine. Both AOPP-HSA and AGE-HSA,
but not purified dityrosine, were capable of triggering the oxidative
burst of human monocytes in cultures. The AOPP-HSA-induced respiratory
burst was dependent on the chlorinated nature of the oxidant and on the
molar ratio HSA/HOCl. Collectively, these data first demonstrate that
AOPP act as a mediator of oxidative stress and monocyte respiratory
burst, which points to monocytes as both target and actor in the immune
dysregulation associated with chronic uremia.
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J. van de Kerkhof, C. G. Schalkwijk, C. J. Konings, E. C. Cheriex, F. M. van der Sande, P. G. Scheffer, P. M. ter Wee, K. M. Leunissen, and J. P. Kooman N {epsilon}-(carboxymethyl)lysine, N {epsilon}-(carboxyethyl)lysine and vascular cell adhesion molecule-1 (VCAM-1) in relation to peritoneal glucose prescription and residual renal function; a study in peritoneal dialysis patients Nephrol. Dial. Transplant., April 1, 2004; 19(4): 910 - 916. [Abstract] [Full Text] [PDF]
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T. Boure and R. Vanholder Which dialyser membrane to choose? Nephrol. Dial. Transplant., February 1, 2004; 19(2): 293 - 296. [Full Text] [PDF]
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M. Kalousova, S. Sulkova, L. Fialova, J. Soukupova, I. M. Malbohan, P. Spacek, M. Braun, L. Mikulikova, M. Fortova, M. Horejsi, et al. Glycoxidation and inflammation in chronic haemodialysis patients Nephrol. Dial. Transplant., December 1, 2003; 18(12): 2577 - 2581. [Abstract] [Full Text] [PDF]
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F. Locatelli, B. Canaud, K.-U. Eckardt, P. Stenvinkel, C. Wanner, and C. Zoccali Oxidative stress in end-stage renal disease: an emerging threat to patient outcome Nephrol. Dial. Transplant., July 1, 2003; 18(7): 1272 - 1280. [Abstract] [Full Text] [PDF]
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M. E. Suliman, O. Heimburger, P. Barany, B. Anderstam, R. Pecoits-Filho, E. Rodriguez Ayala, A. R. Qureshi, I. Fehrman-Ekholm, B. Lindholm, and P. Stenvinkel Plasma Pentosidine Is Associated with Inflammation and Malnutrition in End-Stage Renal Disease Patients Starting on Dialysis Therapy J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1614 - 1622. [Abstract] [Full Text] [PDF]
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K. Amann, C. Ritz, M. Adamczak, and E. Ritz Why is coronary heart disease of uraemic patients so frequent and so devastating? Nephrol. Dial. Transplant., April 1, 2003; 18(4): 631 - 640. [Abstract] [Full Text] [PDF]
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R. Vanholder, G. Glorieux, and N. Lameire Uraemic toxins and cardiovascular disease Nephrol. Dial. Transplant., March 1, 2003; 18(3): 463 - 466. [Full Text] [PDF]
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 R. De Smet, J. Van Kaer, B. Van Vlem, A. De Cubber, P. Brunet, N. Lameire, and R. Vanholder Toxicity of Free p-Cresol: A Prospective and Cross-Sectional Analysis Clin. Chem., March 1, 2003; 49(3): 470 - 478. [Abstract] [Full Text] [PDF]
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 M. G. Shlipak, L. F. Fried, C. Crump, A. J. Bleyer, T. A. Manolio, R. P. Tracy, C. D. Furberg, and B. M. Psaty Elevations of Inflammatory and Procoagulant Biomarkers in Elderly Persons With Renal Insufficiency Circulation, January 7, 2003; 107(1): 87 - 92. [Abstract] [Full Text] [PDF]
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T. Drueke, V. Witko-Sarsat, Z. Massy, B. Descamps-Latscha, A. P. Guerin, S. J. Marchais, V. Gausson, and G. M. London Iron Therapy, Advanced Oxidation Protein Products, and Carotid Artery Intima-Media Thickness in End-Stage Renal Disease Circulation, October 22, 2002; 106(17): 2212 - 2217. [Abstract] [Full Text] [PDF]
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 S. Delbosc, J.-P. Cristol, B. Descomps, A. Mimran, and B. Jover Simvastatin Prevents Angiotensin II-Induced Cardiac Alteration and Oxidative Stress Hypertension, August 1, 2002; 40(2): 142 - 147. [Abstract] [Full Text] [PDF]
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W. H. Horl Hemodialysis Membranes: Interleukins, Biocompatibility, and Middle Molecules J. Am. Soc. Nephrol., January 1, 2002; 13(90001): S62 - 71. [Abstract] [Full Text] [PDF]
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 L. M. Ruilope, D. J. van Veldhuisen, E. Ritz, and T. F. Luscher Renal function: the Cinderella of cardiovascular risk profile J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1782 - 1787. [Abstract] [Full Text] [PDF]
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G. F. Kormoczi, U. M. Wolfel, A. R. Rosenkranz, W. H. Horl, R. Oberbauer, and G. J. Zlabinger Serum Proteins Modified by Neutrophil-Derived Oxidants as Mediators of Neutrophil Stimulation J. Immunol., July 1, 2001; 167(1): 451 - 460. [Abstract] [Full Text] [PDF]
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G. A. KAYSEN The Microinflammatory State in Uremia: Causes and Potential Consequences J. Am. Soc. Nephrol., July 1, 2001; 12(7): 1549 - 1557. [Abstract] [Full Text] [PDF]
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T. Nguyen-Khoa, Z. A. Massy, J. P. De Bandt, M. Kebede, L. Salama, G. Lambrey, V. Witko-Sarsat, T. B. Drueke, B. Lacour, and M. Thevenin Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment Nephrol. Dial. Transplant., February 1, 2001; 16(2): 335 - 340. [Abstract] [Full Text] [PDF]
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A. Wynckel, C. Randoux, H. Millart, C. Desroches, P. Gillery, E. Canivet, and J. Chanard Kinetics of carbamylated haemoglobin in acute renal failure Nephrol. Dial. Transplant., August 1, 2000; 15(8): 1183 - 1188. [Abstract] [Full Text] [PDF]
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P. Stenvinkel, O. Heimburger, B. Lindholm, G. A. Kaysen, and J. Bergstrom Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome) Nephrol. Dial. Transplant., July 1, 2000; 15(7): 953 - 960. [Full Text] [PDF]
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M. Morena, J.-P. Cristol, T. Dantoine, M.-A. Carbonneau, B. Descomps, and B. Canaud Protective effects of high-density lipoprotein against oxidative stress are impaired in haemodialysis patients Nephrol. Dial. Transplant., March 1, 2000; 15(3): 389 - 395. [Abstract] [Full Text] [PDF]
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| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
