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Immunobiology Section, Yale University School of Medicine, New Haven, CT 06520
The liver contains abundant cytotoxic cells, including NK-T cells,
NK cells, and CTLs. However, the regulation of this cytotoxicity is not
fully understood. In this study, we investigated the effect of a
recently described cytokine, IL-18, which is present in large
quantities in the liver, on the cytotoxicity of intrahepatic lymphocyte
subpopulations. This effect of IL-18 was assessed by assaying
the in vitro cytotoxicity of purified NK-T, NK, and T cells against a
CD95- and perforin-sensitive T cell line, Jurkat. The results show that
IL-18 enhances the killing activity of liver NK-T cells by a
CD95-independent, perforin-dependent pathway. IL-18 also augments liver
NK cell activity, but the exact mechanisms of this killing remain to be
elucidated. Finally, the augmentation of the killing activities of
liver NK-T and NK cells by IL-18 is not due to soluble TNF-
, because
none of these cell populations had detectable TNF-
production.
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