The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, R.
Right arrow Articles by Shi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, R.
Right arrow Articles by Shi, Y.
The Journal of Immunology, 1998, 161: 2201-2207.
Copyright © 1998 by The American Association of Immunologists

Protein Kinase C Regulates Fas (CD95/APO-1) Expression1

Ruoxiang Wang, Liying Zhang, Deling Yin, R. Allan Mufson2 and Yufang Shi3

Department of Immunology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD 20855

Fas (CD95/APO-1) is a transmembrane protein of the TNF/neuron growth factor receptor family. Ligation of Fas by specific Abs or Fas ligand (FasL/CD95 ligand) induces rapid apoptotic cell death in a variety of cell types. Despite progress in understanding the death signals transduced from Fas, very little is known with regard to the mechanisms by which Fas expression is regulated. Using our previously established murine T cell hybridoma model A1.1, we show that specific protein kinase C (PKC) inhibitors could block activation-induced Fas expression and apoptosis. The activation of PKC with PMA or 1-oleoyl-2-acetyl-sn-glycerol could mimic the TCR signal by inducing the expression of Fas but not FasL. PKC-dependent Fas expression was also observed in several murine and human tumor cell lines. Since the inhibition of Ca2+ redistribution by an inhibitor of intracellular Ca2+ mobilization, 8-(diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride, inhibited TCR-induced FasL but not Fas, the expression of Fas appears to be independent of Ca2+ mobilization. Significantly, expression of the newly identified Fas-regulatory gene, TDAG51, was found to be dependent upon the activity of PKC. PKC activation only induced Fas expression in cells expressing wild-type TDAG51. Thus, Fas expression is likely mediated by PKC through TDAG51.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. R. Skinner, T. M. Shew, D. M. Schwartz, A. Tzekov, C. M. Lepus, N. A. Abumrad, and N. E. Wolins
Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization
J. Biol. Chem., November 6, 2009; 284(45): 30941 - 30948.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. M. Tillman, K. Izeradjene, K. S. Szucs, L. Douglas, and J. A. Houghton
Rottlerin Sensitizes Colon Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis via Uncoupling of the Mitochondria Independent of Protein Kinase C
Cancer Res., August 15, 2003; 63(16): 5118 - 5125.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
A. Dutta and S. K. Dutta
Vitamin E and its Role in the Prevention of Atherosclerosis and Carcinogenesis: A Review
J. Am. Coll. Nutr., August 1, 2003; 22(4): 258 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
M. Gomez-Angelats and J. A. Cidlowski
Invited Review: Cell Volume Control and Signal Transduction in Apoptosis
Toxicol Pathol, August 1, 2002; 30(5): 541 - 551.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
F. C. Mooren, D. Bloming, A. Lechtermann, M. M. Lerch, and K. Volker
Lymphocyte apoptosis after exhaustive and moderate exercise
J Appl Physiol, July 1, 2002; 93(1): 147 - 153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Li, X. Qi, M. Williams, Y. Shi, and A. D. Keegan
Overexpression of Insulin Receptor Substrate-1, But Not Insulin Receptor Substrate-2, Protects a T Cell Hybridoma from Activation-Induced Cell Death
J. Immunol., June 15, 2002; 168(12): 6215 - 6223.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Francavilla, P. D'Abrizio, G. Cordeschi, F. Pelliccione, S. Necozione, S. Ulisse, G. Properzi, and F. Francavilla
Fas expression correlates with human germ cell degeneration in meiotic and post-meiotic arrest of spermatogenesis
Mol. Hum. Reprod., March 1, 2002; 8(3): 213 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Rho, S. Gong, N. Kim, and Y. Choi
TDAG51 Is Not Essential for Fas/CD95 Regulation and Apoptosis In Vivo
Mol. Cell. Biol., December 15, 2001; 21(24): 8365 - 8370.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. de Thonel, A. Bettaieb, C. Jean, G. Laurent, and A. Quillet-Mary
Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells
Blood, December 15, 2001; 98(13): 3770 - 3777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. Lemonnier, E. Hay, P. Delannoy, O. Fromigue, A. Lomri, D. Modrowski, and P. J. Marie
Increased Osteoblast Apoptosis in Apert Craniosynostosis : Role of Protein Kinase C and Interleukin-1
Am. J. Pathol., May 1, 2001; 158(5): 1833 - 1842.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. NEUZIL, T. WEBER, A. SCHRODER, M. LU, G. OSTERMANN, N. GELLERT, G. C. MAYNE, B. OLEJNICKA, A. NEGRE-SALVAYRE, M. STICHA, et al.
Induction of cancer cell apoptosis by {alpha}-tocopheryl succinate: molecular pathways and structural requirements
FASEB J, February 1, 2001; 15(2): 403 - 415.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Wang, L. Zhang, X. Zhang, J. Moreno, X. Luo, M. Tondravi, and Y. Shi
Differential Regulation of the Expression of CD95 Ligand, Receptor Activator of Nuclear Factor-{{kappa}}B Ligand (RANKL), TNF-Related Apoptosis-Inducing Ligand (TRAIL), and TNF-{{alpha}} During T Cell Activation
J. Immunol., February 1, 2001; 166(3): 1983 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Delgado and D. Ganea
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Antigen-Induced Apoptosis of Mature T Lymphocytes by Inhibiting Fas Ligand Expression
J. Immunol., February 1, 2000; 164(3): 1200 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. R. Li, A. S.-F. Chong, J. Wu, K. A. Roebuck, A. Kumar, J. E. Parrillo, U. R. Rapp, R. P. Kimberly, J. W. Williams, and X. Xu
Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor{middle dot}CD3 Complex-stimulated T Cells
J. Biol. Chem., December 3, 1999; 274(49): 35203 - 35210.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
M. D. S. Jean, F. Brignole, G. Feldmann, A. Goguel, and C. Baudouin
Interferon-{gamma} Induces Apoptosis and Expression of Inflammation-Related Proteins in Chang Conjunctival Cells
Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2199 - 2212.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
E. E. Prieschl, R. Csonga, V. Novotny, G. E. Kikuchi, and T. Baumruker
The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fcisin Receptor I Triggering
J. Exp. Med., July 1, 1999; 190(1): 1 - 8.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.