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Department of Oncology and Immunology, Division of Surgery, John Hunter Hospital, Newcastle, New South Wales, Australia
We have previously shown that melanoma cells were resistant to
apoptosis induced by TNF family members Fas ligand (FasL), TNF-
, and
CD40L. FasL also was not involved in CD4 T cell-mediated killing of
melanoma cells. In the present study, we have tested melanoma cells for
their susceptibility to apoptosis induced by human TNF-related
apoptosis-inducing ligand (TRAIL) and the ability of a mAb against
TRAIL to inhibit apoptosis and CD4 CTL-mediated killing of melanoma and
Jurkat target cells. The results show that TRAIL-induced apoptosis in
cells from 7 of 10 melanoma cell lines tested as well as in Jurkat T
cells. Susceptibility to apoptosis was increased in some of the cell
lines by treatment with cyclohexamide or actinomycin D. The melanoma
cells were resistant to apoptosis induced by FasL, TNF-, and CD40L.
mAb M180 against TRAIL inhibited apoptosis induced by TRAIL. It was
also found to inhibit CD4 CTL-mediated killing of Jurkat T cells as
well as autologous and allogeneic melanoma cells. The degree of
inhibition produced by the mAb varied between different clones of CTL
and according to the susceptibility of the target cells to
TRAIL-induced apoptosis. These results suggest that TRAIL is an
important mediator of cell death induced by CTL and may have an
important therapeutic role against human
melanoma.
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D. Siegmund, A. Hausser, N. Peters, P. Scheurich, and H. Wajant Tumor Necrosis Factor (TNF) and Phorbol Ester Induce TNF-related Apoptosis-inducing Ligand (TRAIL) under Critical Involvement of NF-kappa B Essential Modulator (NEMO)/IKKgamma J. Biol. Chem., November 16, 2001; 276(47): 43708 - 43712. [Abstract] [Full Text] [PDF]
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A. E. Tollefson, K. Toth, K. Doronin, M. Kuppuswamy, O. A. Doronina, D. L. Lichtenstein, T. W. Hermiston, C. A. Smith, and W. S. M. Wold Inhibition of TRAIL-Induced Apoptosis and Forced Internalization of TRAIL Receptor 1 by Adenovirus Proteins J. Virol., October 1, 2001; 75(19): 8875 - 8887. [Abstract] [Full Text] [PDF]
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X. D. Zhang, X. Y. Zhang, C. P. Gray, T. Nguyen, and P. Hersey Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis of Human Melanoma Is Regulated by Smac/DIABLO Release from Mitochondria Cancer Res., October 1, 2001; 61(19): 7339 - 7348. [Abstract] [Full Text] [PDF]
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K. Hallermalm, K. Seki, C. Wei, C. Castelli, L. Rivoltini, R. Kiessling, and J. Levitskaya Tumor necrosis factor-{alpha} induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface Blood, August 15, 2001; 98(4): 1108 - 1115. [Abstract] [Full Text] [PDF]
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C. S. Mitsiades, S. P. Treon, N. Mitsiades, Y. Shima, P. Richardson, R. Schlossman, T. Hideshima, and K. C. Anderson TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications Blood, August 1, 2001; 98(3): 795 - 804. [Abstract] [Full Text] [PDF]
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M. Chawla-Sarkar, D. W. Leaman, and E. C. Borden Preferential Induction of Apoptosis by Interferon (IFN)-{beta} Compared with IFN-{{alpha}}2: Correlation with TRAIL/Apo2L Induction in Melanoma Cell Lines Clin. Cancer Res., June 1, 2001; 7(6): 1821 - 1831. [Abstract] [Full Text] [PDF]
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K. Ogawa, K. Tanaka, A. Ishii, Y. Nakamura, S. Kondo, K. Sugamura, S. Takano, M. Nakamura, and K. Nagata A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes J. Immunol., May 15, 2001; 166(10): 6404 - 6412. [Abstract] [Full Text] [PDF]
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S. Liu, Y. Yu, M. Zhang, W. Wang, and X. Cao The Involvement of TNF-{{alpha}}-Related Apoptosis-Inducing Ligand in the Enhanced Cytotoxicity of IFN-{{beta}}-Stimulated Human Dendritic Cells to Tumor Cells J. Immunol., May 1, 2001; 166(9): 5407 - 5415. [Abstract] [Full Text] [PDF]
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C. Schmaltz, O. Alpdogan, K. J. Horndasch, S. J. Muriglan, B. J. Kappel, T. Teshima, J. L. M. Ferrara, S. J. Burakoff, and M. R. M. van den Brink Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect Blood, May 1, 2001; 97(9): 2886 - 2895. [Abstract] [Full Text] [PDF]
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G. Niu, K. H. Shain, M. Huang, R. Ravi, A. Bedi, W. S. Dalton, R. Jove, and H. Yu Overexpression of a Dominant-Negative Signal Transducer and Activator of Transcription 3 Variant in Tumor Cells Leads to Production of SolubleFactors That Induce Apoptosis and Cell Cycle Arrest Cancer Res., April 1, 2001; 61(8): 3276 - 3280. [Abstract] [Full Text]
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N. Mitsiades, V. Poulaki, C. Mitsiades, and M. Tsokos Ewing's Sarcoma Family Tumors Are Sensitive to Tumor Necrosis Factor-related Apoptosis-inducing Ligand and Express Death Receptor 4 and Death Receptor 5 Cancer Res., March 1, 2001; 61(6): 2704 - 2712. [Abstract] [Full Text]
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W. D. Thomas, X. D. Zhang, A. V. Franco, T. Nguyen, and P. Hersey TNF-Related Apoptosis-Inducing Ligand-Induced Apoptosis of Melanoma Is Associated with Changes in Mitochondrial Membrane Potential and Perinuclear Clustering of Mitochondria J. Immunol., November 15, 2000; 165(10): 5612 - 5620. [Abstract] [Full Text] [PDF]
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I. Petak, L. Douglas, D. M. Tillman, R. Vernes, and J. A. Houghton Pediatric Rhabdomyosarcoma Cell Lines Are Resistant to Fas-induced Apoptosis and Highly Sensitive to TRAIL-induced Apoptosis Clin. Cancer Res., October 1, 2000; 6(10): 4119 - 4127. [Abstract] [Full Text]
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X. D. Zhang, A. V. Franco, T. Nguyen, C. P. Gray, and P. Hersey Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells J. Immunol., April 15, 2000; 164(8): 3961 - 3970. [Abstract] [Full Text] [PDF]
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S. H. Lee, M. S. Shin, H. S. Kim, H. K. Lee, W. S. Park, S. Y. Kim, J. H. Lee, S. Y. Han, J. Y. Park, R. R. Oh, et al. Alterations of the DR5/TRAIL Receptor 2 Gene in Non-Small Cell Lung Cancers Cancer Res., November 1, 1999; 59(22): 5683 - 5686. [Abstract] [Full Text] [PDF]
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H. Winter, H.-M. Hu, W. J. Urba, and B. A. Fox Tumor Regression After Adoptive Transfer of Effector T Cells Is Independent of Perforin or Fas Ligand (APO-1L/CD95L) J. Immunol., October 15, 1999; 163(8): 4462 - 4472. [Abstract] [Full Text] [PDF]
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S.-i. Wakamatsu, M. Makino, C. Tei, and M. Baba Monocyte-Driven Activation-Induced Apoptotic Cell Death of Human T-Lymphotropic Virus Type I-Infected T Cells J. Immunol., October 1, 1999; 163(7): 3914 - 3919. [Abstract] [Full Text] [PDF]
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N. Kayagaki, N. Yamaguchi, M. Nakayama, K. Takeda, H. Akiba, H. Tsutsui, H. Okamura, K. Nakanishi, K. Okumura, and H. Yagita Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells J. Immunol., August 15, 1999; 163(4): 1906 - 1913. [Abstract] [Full Text] [PDF]
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 C. Beltinger, S. Fulda, T. Kammertoens, E. Meyer, W. Uckert, and K.-M. Debatin Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases PNAS, July 20, 1999; 96(15): 8699 - 8704. [Abstract] [Full Text] [PDF]
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X. D. Zhang, A. Franco, K. Myers, C. Gray, T. Nguyen, and P. Hersey Relation of TNF-related Apoptosis-inducing Ligand (TRAIL) Receptor and FLICE-inhibitory Protein Expression to TRAIL-induced Apoptosis of Melanoma Cancer Res., June 1, 1999; 59(11): 2747 - 2753. [Abstract] [Full Text] [PDF]
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N. Kayagaki, N. Yamaguchi, M. Nakayama, H. Eto, K. Okumura, and H. Yagita Type I Interferons (IFNs) Regulate Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs J. Exp. Med., May 3, 1999; 189(9): 1451 - 1460. [Abstract] [Full Text] [PDF]
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S. Mori, K. Murakami-Mori, S. Nakamura, A. Ashkenazi, and B. Bonavida Sensitization of AIDS-Kaposi's Sarcoma Cells to Apo-2 Ligand-Induced Apoptosis by Actinomycin D J. Immunol., May 1, 1999; 162(9): 5616 - 5623. [Abstract] [Full Text] [PDF]
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 L. L. Perry, K. Feilzer, S. Hughes, and H. D. Caldwell Clearance of Chlamydia trachomatis from the Murine Genital Mucosa Does Not Require Perforin-Mediated Cytolysis or Fas-Mediated Apoptosis Infect. Immun., March 1, 1999; 67(3): 1379 - 1385. [Abstract] [Full Text] [PDF]
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N. Kayagaki, N. Yamaguchi, M. Nakayama, A. Kawasaki, H. Akiba, K. Okumura, and H. Yagita Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity J. Immunol., March 1, 1999; 162(5): 2639 - 2647. [Abstract] [Full Text] [PDF]
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L. Zamai, M. Ahmad, I. M. Bennett, L. Azzoni, E. S. Alnemri, and B. Perussia Natural Killer (NK) Cell-mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells J. Exp. Med., December 21, 1998; 188(12): 2375 - 2380. [Abstract] [Full Text] [PDF]
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C. A. Benedict, P. S. Norris, T. I. Prigozy, J.-L. Bodmer, J. A. Mahr, C. T. Garnett, F. Martinon, J. Tschopp, L. R. Gooding, and C. F. Ware Three Adenovirus E3 Proteins Cooperate to Evade Apoptosis by Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor-1 and -2 J. Biol. Chem., January 26, 2001; 276(5): 3270 - 3278. [Abstract] [Full Text] [PDF]
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A. K. Simon, O. Williams, J. Mongkolsapaya, B. Jin, X. N. Xu, H. Walczak, and G. R. Screaton Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes PNAS, April 24, 2001; 98(9): 5158 - 5163. [Abstract] [Full Text] [PDF]
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