HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Offner, H. Articles by Vandenbark, A. A. Search for Related Content PubMed PubMed Citation Articles by Offner, H. Articles by Vandenbark, A. A.

Vaccination with BV8S2 Protein Amplifies TCR-Specific Regulation and Protection Against Experimental Autoimmune Encephalomyelitis in TCR BV8S2 Transgenic Mice¹

Halina Offner^2,*,, Kirsten Adlard^*, Bruce F. Bebo, Jr.^*,, Jeanette Schuster^*, Gregory G. Burrows^*,,, Abigail C. Buenafe and Arthur A. Vandenbark^*,,§

^* Neuroimmunology Research R&D-31, Portland Veterans Affairs Medical Center, and Departments of Neurology, Biochemistry and Molecular Biology, and ^§ Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201

TCR determinants overexpressed by autopathogenic Th1 cells can naturally induce a second set of TCR-specific regulatory T cells. We addressed the question of whether immune regulation could be induced naturally in a genetically restricted model in which a major portion of TCR-specific regulatory T cells expressed the same target TCR BV8S2 chain as the pathogenic T cells specific for myelin basic protein (MBP). We found vigorous T cell responses to BV8S2 determinants in naive mice that could be further potentiated by vaccination with heterologous BV8S2 proteins, resulting in the selective inhibition of MBP-specific Th1 cells and protection against experimental encephalomyelitis. Moreover, coculture with BV8S2-specific T cells or their supernatants reduced proliferation, IFN- secretion, and encephalitogenic activity of MBP-specific T cells. These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism.

This article has been cited by other articles:

				R. H. McMahan, L. Watson, R. Meza-Romero, G. G. Burrows, D. N. Bourdette, and A. C. Buenafe Production, Characterization, and Immunogenicity of a Soluble Rat Single Chain T Cell Receptor Specific for an Encephalitogenic Peptide J. Biol. Chem., August 15, 2003; 278(33): 30961 - 30970. [Abstract] [Full Text] [PDF]

				A. Matejuk, A. A. Vandenbark, G. G. Burrows, B. F. Bebo Jr., and H. Offner Reduced Chemokine and Chemokine Receptor Expression in Spinal Cords of TCR BV8S2 Transgenic Mice Protected Against Experimental Autoimmune Encephalomyelitis with BV8S2 Protein J. Immunol., April 1, 2000; 164(7): 3924 - 3931. [Abstract] [Full Text] [PDF]