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,
Departments of
*
Neurology and
Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201;
Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201; and
§
R. S. Dow Neurological Sciences Institute, Legacy Good Samaritan Hospital and Medical Center, Portland, OR 97209.
T cells infiltrating the iris/ciliary body of Lewis rats with
anterior uveitis (AU) that had been induced by myelin basic protein
(MBP) immunization were previously found to share surface markers
common to the T cells that cause experimental autoimmune
encephalomyelitis (EAE). To determine whether these AU-associated T
cells are in fact the same as those that infiltrate the central nervous
system to cause EAE, we examined TCR V gene expression in T cells
infiltrating the anterior chamber in rats with AU. As with EAE, we
found a biased expression of Vß8.2 and V
2 in the iris/ciliary body
and, although one would expect an influx of nonspecific inflammatory T
cells, these biases were still evident at the peak of AU. An analysis
of the TCR Vß8.2 and V2 sequences derived from the iris/ciliary
body demonstrated the presence of the same complementarity determining
region 3 motifs found in MBP-specific T cells that are pathogenic for
EAE and found in T cells derived from the central nervous system of
rats with EAE. Finally, T cells isolated from the iris/ciliary
body of rats with AU were found to proliferate in a specific fashion to
MBP Ags. Thus, it appears that MBP-specific T cells are pathogenic for
AU as well as EAE in the Lewis rat. In addition, the long-term presence
of this highly restricted MBP response in the iris/ciliary body
indicates that distinct immunoregulatory mechanisms exist in the
environment of the eye. This provides an interesting model with which
to address questions pertaining to the nature of T cells infiltrating
the eye and their regulation during EAE and other systemic
diseases.
This article has been cited by other articles:
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 F. Mor, F. Quintana, A. Mimran, and I. R. Cohen Autoimmune Encephalomyelitis and Uveitis Induced by T Cell Immunity to Self {beta}-Synuclein J. Immunol., January 1, 2003; 170(1): 628 - 634. [Abstract] [Full Text] [PDF]
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X. Zhang, S. Jiang, M. Manczak, B. Sugden, and G. Adamus Phenotypes of T Cells Infiltrating the Eyes in Autoimmune Anterior Uveitis Associated with EAE Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1499 - 1508. [Abstract] [Full Text] [PDF]
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A. F. de Vos, A. D. Dick, J. Klooster, L. Broersma, P. G. McMenamin, and A. Kijlstra Analysis of the Cellular Infiltrate in the Iris during Experimental Autoimmune Encephalomyelitis Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3001 - 3010. [Abstract] [Full Text]
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