| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pathology (Neuropathology), Albert Einstein College of Medicine, Bronx, NY 10461
Because IL-1 is implicated in the pathogenesis of multiple
sclerosis, and IFNs are known to alter disease course, we sought to
determine whether IFNs can regulate the expression of IL-1 and IL-1R
antagonist (IL-1Ra) in primary cultures of human microglia and
astrocytes. We found that IL-1 and IL-1Ra are products of microglia but
not astrocytes, and IFN-ß and IFN-
differentially modulate LPS-
and cytokine-induced IL-1 and IL-1Ra. IFN-ß induces IL-1Ra and
augments LPS- and IL-4-induced IL-1Ra, but suppresses LPS- and
IL-1-induced IL-1, shifting the balance toward the expression of the
IL-1Ra. Like IFN-ß, IFN- suppresses the expression of both LPS and
IL-1-induced IL-1ß. However, IFN- also suppresses the expression
of IFN-ß- and IL-4-induced IL-1Ra so that IFN- may enhance or
suppress IL-1 activity depending on the other cytokines present. IL-4
has similar effects to IFN-ß; however, other anti-inflammatory
cytokines, did not regulate IL-1 or IL-1Ra in human microglia. Our data
demonstrate a novel suppressive effect of IFN-ß and IL-4 on IL-1
activity in human microglia, suggesting that IFN-ß, a therapeutic
agent used for multiple sclerosis, could have wider applications in the
treatment of other central nervous system disorders in which IL-1
activity has been implicated in the
pathogenesis.
This article has been cited by other articles:
|
|
 |
|
  H.-S. Suh, M.-L. Zhao, M. Rivieccio, S. Choi, E. Connolly, Y. Zhao, O. Takikawa, C. F. Brosnan, and S. C. Lee Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the TLR3 Ligand Poly(I:C): Mechanism of Induction and Role in Antiviral Response J. Virol., September 15, 2007; 81(18): 9838 - 9850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Si, M.-L. Zhao, A. C. A. Morgan, C. F. Brosnan, and S. C. Lee 15-Deoxy-{Delta}12,14-Prostaglandin J2 Inhibits IFN-Inducible Protein 10/CXC Chemokine Ligand 10 Expression in Human Microglia: Mechanisms and Implications J. Immunol., September 1, 2004; 173(5): 3504 - 3513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Palmer, F Mezin, C E Juge-Aubry, C Plater-Zyberk, C Gabay, and P-A Guerne Interferon {beta} stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts Ann Rheum Dis, January 1, 2004; 63(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. John, S. C. Lee, and C. F. Brosnan Cytokines: Powerful Regulators of Glial Cell Activation Neuroscientist, February 1, 2003; 9(1): 10 - 22. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Haspolat, B. Anlar, G. Kose, M. Coskun, and O. Yegin Interleukin-1{beta}, Interleukin-1 Receptor Antagonist Levels in Patients With Subacute Sclerosing Panencephalitis and the Effects of Different Treatment Protocols J Child Neurol, June 1, 2001; 16(6): 417 - 420. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Kumpfel, F. T. Bergh, T. Pollmacher, F. Holsboer, and C. Trenkwalder Acute effects of interferon beta-1a on plasma cytokine levels in patients with MS Neurology, October 24, 2000; 55(8): 1231 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. H. Liu, G. R. John, A. Sikora, S. C. Lee, and C. F. Brosnan Modulation of Interleukin-1beta and Tumor Necrosis Factor alpha Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes J. Neurosci., July 15, 2000; 20(14): 5292 - 5299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hu, H. Ali, W. S. Sheng, L. C. Ehrlich, P. K. Peterson, and C. C. Chao Gp-41-Mediated Astrocyte Inducible Nitric Oxide Synthase mRNA Expression: Involvement of Interleukin-1beta Production by Microglia J. Neurosci., August 1, 1999; 19(15): 6468 - 6474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Reznikov, S.-H. Kim, J. Y. Westcott, J. Frishman, G. Fantuzzi, D. Novick, M. Rubinstein, and C. A. Dinarello IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma PNAS, February 29, 2000; 97(5): 2174 - 2179. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
