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*
Cell Adhesion Laboratory, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije University, Amsterdam, The Netherlands; and
Department of Neuroscience, SmithKline Beecham, Harlow, United Kingdom
Signal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC, and a cytoplasmic domain with two immunoreceptor with tyrosine-based inhibition motifs that can interact with src homology 2 domain-containing phosphatases. SIRP have previously been shown to inhibit signaling through receptor tyrosine kinases, but their physiologic function is unknown. Here we demonstrate by expression cloning that the mAbs ED9, ED17, and MRC-OX41 recognize rat SIRP. In addition, we show for the first time that rat SIRP is selectively expressed by myeloid cells (macrophages, monocytes, granulocytes, dendritic cells) and neurons. Moreover, SIRP ligation induces nitric oxide production by macrophages. This implicates SIRP as a putative recognition/signaling receptor in both immune and nervous systems.
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H. Yoshida, Y. Tomiyama, J. Ishikawa, K. Oritani, I. Matsumura, M. Shiraga, T. Yokota, Y. Okajima, M. Ogawa, J.-i. Miyagawa, et al. Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42 Blood, July 1, 2000; 96(1): 234 - 241. [Abstract] [Full Text] [PDF]
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I. Babic, A. Schallhorn, F. P. Lindberg, and F. R. Jirik SHPS-1 Induces Aggregation of Ba/F3 Pro-B Cells Via an Interaction with CD47 J. Immunol., April 1, 2000; 164(7): 3652 - 3658. [Abstract] [Full Text] [PDF]
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F.-P. Huang, N. Platt, M. Wykes, J. R. Major, T. J. Powell, C. D. Jenkins, and G. G. MacPherson A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes J. Exp. Med., February 7, 2000; 191(3): 435 - 444. [Abstract] [Full Text] [PDF]
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J. Dietrich, M. Cella, M. Seiffert, H.-J. Buhring, and M. Colonna Cutting Edge: Signal-Regulatory Protein {beta}1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells J. Immunol., January 1, 2000; 164(1): 9 - 12. [Abstract] [Full Text] [PDF]
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M. Seiffert, C. Cant, Z. Chen, I. Rappold, W. Brugger, L. Kanz, E. J. Brown, A. Ullrich, and H.-J. Buhring Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47 Blood, December 1, 1999; 94(11): 3633 - 3643. [Abstract] [Full Text] [PDF]
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H. Lienard, P. Bruhns, O. Malbec, W. H. Fridman, and M. Daeron Signal Regulatory Proteins Negatively Regulate Immunoreceptor-dependent Cell Activation J. Biol. Chem., November 5, 1999; 274(45): 32493 - 32499. [Abstract] [Full Text] [PDF]
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P. Jiang, C. F. Lagenaur, and V. Narayanan Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule J. Biol. Chem., January 8, 1999; 274(2): 559 - 562. [Abstract] [Full Text] [PDF]
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R. A. Rebres, J. M. Green, M. I. Reinhold, M. Ticchioni, and E. J. Brown Membrane Raft Association of CD47 Is Necessary for Actin Polymerization and Protein Kinase C theta Translocation in Its Synergistic Activation of T Cells J. Biol. Chem., March 2, 2001; 276(10): 7672 - 7680. [Abstract] [Full Text] [PDF]
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R. A. Rebres, L. E. Vaz, J. M. Green, and E. J. Brown Normal Ligand Binding and Signaling by CD47 (Integrin-associated Protein) Requires a Long Range Disulfide Bond between the Extracellular and Membrane-spanning Domains J. Biol. Chem., September 7, 2001; 276(37): 34607 - 34616. [Abstract] [Full Text] [PDF]
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