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1
*
Departament de Fisiologia (Immunologia), Facultat de Biologia and Fundacio August Pi i Sunyer, Campus de Bellvitge, Universitat de Barcelona, Barcelona, Spain; and
Basel Institute for Immunology, Basel, Switzerland and Department of Immunology and Oncology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
MHC class II molecules are expressed in a limited number of cell
types, including B lymphocytes and macrophages (M
). IFN-
increases the surface expression of class II molecules in a murine B
cell line without inducing detectable changes in either I-A or I-A mRNA
levels. In bone marrow-derived M, IFN- causes an increase in
class II expression at both the mRNA and surface levels. In addition to
the increase in transcription rates described for M, IFN-
increases the rate of synthesis of IA
and IAß proteins and the
ribosome loading for both mRNA molecules in both cell types.
Interestingly, there is a significant peak of free I-A mRNA in
noninduced cells. Therefore, IFN- regulates the expression of MHC
class II molecules at the translational level in both B cells and M
and, as already reported, at the transcriptional level only in M.
The actual mechanism of regulation causes changes in the translation
initiation rates in both cell types, as demonstrated by an increase in
ribosome loading in polysome gradients.
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