| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI 53706
We are interested in understanding the molecular basis of
macrophage (M
) differentiation and activation by cytokines.
Recent reports have suggested that the transcription factor STAT5 may
play a role in M differentiation. In the experiments described here,
we assessed the expression of STAT5-related molecules in three M
cell lines, RAW 264.7, WEHI-3, and WEHI-3D+, which
represent different stages of M maturation, and also in primary
peritoneal and bone marrow M from BALB/c mice. The studies revealed
that the previously characterized STAT5a and STAT5b isoforms are
detectable at both the mRNA and protein levels in these M
populations. Additional STAT5-related proteins were detected by
immunoblot analysis and were preferentially expressed in both the
immature WEHI-3 cell population and the adherent bone marrow population
containing immature M. These results identify new isoforms of STAT5
and demonstrate that distinct patterns of expression of STAT5-related
proteins are observed in M at different stages of
maturation.
This article has been cited by other articles:
|
|
 |
|
  Y. Huang, J. Qiu, S. Dong, M. S. Redell, V. Poli, M. A. Mancini, and D. J. Tweardy Stat3 Isoforms, {alpha} and , Demonstrate Distinct Intracellular Dynamics with Prolonged Nuclear Retention of Stat3 Mapping to Its Unique C-terminal End J. Biol. Chem., November 30, 2007; 282(48): 34958 - 34967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Crotti, M. Lusic, R. Lupo, P. M. J. Lievens, E. Liboi, G. D. Chiara, M. Tinelli, A. Lazzarin, B. K. Patterson, M. Giacca, et al. Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression Blood, June 15, 2007; 109(12): 5380 - 5389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dong, D. L. Stenoien, J. Qiu, M. A. Mancini, and D. J. Tweardy Reduced Intranuclear Mobility of APL Fusion Proteins Accompanies Their Mislocalization and Results in Sequestration and Decreased Mobility of Retinoid X Receptor {alpha} Mol. Cell. Biol., May 15, 2004; 24(10): 4465 - 4475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Chee and B. Roizman Herpes Simplex Virus 1 Gene Products Occlude the Interferon Signaling Pathway at Multiple Sites J. Virol., April 15, 2004; 78(8): 4185 - 4196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler Signal transducer and activator of transcription proteins in leukemias Blood, April 15, 2003; 101(8): 2940 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Helander, J.-A. Gustafsson, and A. Mode Possible Involvement of Truncated Signal Transducer and Activator of Transcription-5 in the GH Pattern-Dependent Regulation of CYP2C12 Gene Expression in Rat Liver Mol. Endocrinol., July 1, 2002; 16(7): 1598 - 1611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lehtonen, S. Matikainen, M. Miettinen, and I. Julkunen Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation J. Leukoc. Biol., March 1, 2002; 71(3): 511 - 519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Barber, B. K. Beattie, J. M. Mason, M. H.-H. Nguyen, M. Yoakim, B. G. Neel, A. D. D'Andrea, and D. A. Frank A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation Blood, April 15, 2001; 97(8): 2230 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Piazza, J. Valens, E. Lagasse, and C. Schindler Myeloid differentiation of FdCP1 cells is dependent on Stat5 processing Blood, August 15, 2000; 96(4): 1358 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bovolenta, L. Camorali, A. L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, and G. Poli Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection Blood, December 15, 1999; 94(12): 4202 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lee, F. Piazza, S. Brutsaert, J. Valens, I. Strehlow, M. Jarosinski, C. Saris, and C. Schindler Characterization of the Stat5 Protease J. Biol. Chem., September 17, 1999; 274(38): 26767 - 26775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Revy, C. Hivroz, G. Andreu, P. Graber, C. Martinache, A. Fischer, and A. Durandy Activation of the Janus Kinase 3-STAT5a Pathway After CD40 Triggering of Human Monocytes But Not of Resting B Cells J. Immunol., July 15, 1999; 163(2): 787 - 793. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
