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CUTTING EDGE |
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI 53706
We are interested in understanding the molecular basis of
macrophage (M
) differentiation and activation by cytokines.
Recent reports have suggested that the transcription factor STAT5 may
play a role in M differentiation. In the experiments described here,
we assessed the expression of STAT5-related molecules in three M
cell lines, RAW 264.7, WEHI-3, and WEHI-3D+, which
represent different stages of M maturation, and also in primary
peritoneal and bone marrow M from BALB/c mice. The studies revealed
that the previously characterized STAT5a and STAT5b isoforms are
detectable at both the mRNA and protein levels in these M
populations. Additional STAT5-related proteins were detected by
immunoblot analysis and were preferentially expressed in both the
immature WEHI-3 cell population and the adherent bone marrow population
containing immature M. These results identify new isoforms of STAT5
and demonstrate that distinct patterns of expression of STAT5-related
proteins are observed in M at different stages of
maturation.
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