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Down-Modulation of a Novel Bax-Associated Protein During Apoptosis in Normal Mature B Lymphocytes¹

Huiling He^2,*, Pamela A. Hershberger^3,* and Susan A. McCarthy^4,*,

Departments of ^* Surgery and Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213

We have recently characterized a novel 16-kDa Bax-associated protein. In this study, we investigate the regulation of this protein’s expression during in vitro induction of apoptosis in mature splenic B cells. A panel of biochemically distinct apoptotic stimuli induced the dramatic down-modulation of the 16-kDa protein in B cells; this down-modulation was rapid, and did not require DNA fragmentation. Reciprocally, stimuli that induced protection from apoptosis prevented down-modulation of the 16-kDa protein. These regulatory effects were specific, since Bcl-2 and Bax protein levels were not similarly modulated. Stimuli that reduce expression of the 16-kDa protein may therefore act indirectly to increase the proapoptotic activity of Bax, perhaps by altering Bax binding to other cellular proteins.

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				H. He, P. A. Hershberger, and S. A. McCarthy Down-Modulation of a Novel Bax-Associated Protein During Apoptosis in Normal Mature B Lymphocytes J. Immunol., August 1, 1998; 161(3): 1176 - 1182. [Abstract] [Full Text] [PDF]