|
|
||||||||
CUTTING EDGE |




*
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy;
Shionogi Institute for Medical Science, Osaka, Japan; and
Department of Biotechnology, Section of General Pathology, University of Brescia, Italy
Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present Ag. CC chemokines induce chemotactic and transendothelial migration of immature DC, in vitro. Maturation of DC by CD40L, or by LPS, IL-1, and TNF, induces down-regulation of the two main CC chemokine receptors expressed by these cells, CCR1 and CCR5, and abrogates chemotaxis to their ligands. Inhibition was rapid (<1 h) and included the unrelated agent FMLP. Concomitantly, the expression of CCR7 and the migration to its ligand EBI1 ligand chemokine (ELC)/macrophage inflammatory protein (MIP)-3ß, a chemokine expressed in lymphoid organs, were strongly up-regulated, though with slower kinetics (2448 h). Rapid inhibition of responsiveness to chemoattractants present at sites of inflammation and immune reaction may be permissive for leaving peripheral tissues. Conversely, the slower acquisition of responsiveness to ELC/MIP-3ß may guide subsequent localization of DC in lymphoid organs.
This article has been cited by other articles:
![]() |
D. A. Fraser, A. K. Laust, E. L. Nelson, and A. J. Tenner C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells J. Immunol., November 15, 2009; 183(10): 6175 - 6185. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. A. Degar and B. J. Rollins Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one? Dis. Model. Mech., September 1, 2009; 2(9-10): 436 - 439. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Barroso-Gonzalez, N. El Jaber-Vazdekis, L. Garcia-Exposito, J.-D. Machado, R. Zarate, A. G. Ravelo, A. Estevez-Braun, and A. Valenzuela-Fernandez The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities J. Biol. Chem., June 12, 2009; 284(24): 16609 - 16620. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. S. McKimmie, M. Moore, A. R. Fraser, T. Jamieson, D. Xu, C. Burt, N. I. Pitman, R. J. Nibbs, I. B. McInnes, F. Y. Liew, et al. A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration Blood, April 30, 2009; 113(18): 4224 - 4231. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Abt, E. Gassert, and S. Schneider-Schaulies Measles virus modulates chemokine release and chemotactic responses of dendritic cells J. Gen. Virol., April 1, 2009; 90(4): 909 - 914. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Spadaro, C. Caorsi, P. Ceruti, A. Varadhachary, G. Forni, F. Pericle, and M. Giovarelli Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells FASEB J, August 1, 2008; 22(8): 2747 - 2757. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Vasir, Z. Wu, K. Crawford, J. Rosenblatt, C. Zarwan, A. Bissonnette, D. Kufe, and D. Avigan Fusions of Dendritic Cells with Breast Carcinoma Stimulate the Expansion of Regulatory T Cells while Concomitant Exposure to IL-12, CpG Oligodeoxynucleotides, and Anti-CD3/CD28 Promotes the Expansion of Activated Tumor Reactive Cells J. Immunol., July 1, 2008; 181(1): 808 - 821. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. R. Cicinnati, J. Kang, G. C. Sotiropoulos, P. Hilgard, A. Frilling, C. E. Broelsch, G. Gerken, and S. Beckebaum Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of alpha interferon J. Gen. Virol., May 1, 2008; 89(5): 1243 - 1253. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A. Arias, G. Jaramillo, Y. P. Lopez, N. Mejia, C. Mejia, A. E. Pantoja, R. J. Shattock, L. F. Garcia, and G. E. Griffin Mycobacterium tuberculosis Antigens Specifically Modulate CCR2 and MCP-1/CCL2 on Lymphoid Cells from Human Pulmonary Hilar Lymph Nodes J. Immunol., December 15, 2007; 179(12): 8381 - 8391. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Bouma, S. Burns, and A. J. Thrasher Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells Blood, December 15, 2007; 110(13): 4278 - 4284. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Krause, E. Singer, P. I. Darley, J. Klebensberger, M. Groettrup, and D. F. Legler Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO J. Leukoc. Biol., November 1, 2007; 82(5): 1106 - 1114. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Jenkins, G. Perona-Wright, A. G. F. Worsley, N. Ishii, and A. S. MacDonald Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo J. Immunol., September 15, 2007; 179(6): 3515 - 3523. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Schroder, R. N. Pierson III, B.-N. H. Nguyen, D. W. Kawka, L. B. Peterson, G. Wu, T. Zhang, M. S. Springer, S. J. Siciliano, S. Iliff, et al. CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates J. Immunol., August 15, 2007; 179(4): 2289 - 2299. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Mariani, S. Gilles, T. Jakob, M. Thiel, M. J. Mueller, J. Ring, H. Behrendt, and C. Traidl-Hoffmann Immunomodulatory Mediators from Pollen Enhance the Migratory Capacity of Dendritic Cells and License Them for Th2 Attraction J. Immunol., June 15, 2007; 178(12): 7623 - 7631. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. M. Pierce, K. Carpenter, C. Jakubzick, S. L. Kunkel, H. Evanoff, K. R. Flaherty, F. J. Martinez, G. B. Toews, and C. M. Hogaboam Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21 Eur. Respir. J., June 1, 2007; 29(6): 1082 - 1093. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Bertram, S. Baltic, N. L. Misso, K. D. Bhoola, P. S. Foster, P. J. Thompson, and M. Fogel-Petrovic Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration J. Leukoc. Biol., June 1, 2007; 81(6): 1445 - 1454. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-L. del Rio, J.-I. Rodriguez-Barbosa, E. Kremmer, and R. Forster CD103- and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells J. Immunol., June 1, 2007; 178(11): 6861 - 6866. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Courreges, D. Burzyn, I. Nepomnaschy, I. Piazzon, and S. R. Ross Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection J. Virol., April 15, 2007; 81(8): 3769 - 3777. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Bayry, F. Triebel, S. V. Kaveri, and D. F. Tough Human Dendritic Cells Acquire a Semimature Phenotype and Lymph Node Homing Potential through Interaction with CD4+CD25+ Regulatory T Cells J. Immunol., April 1, 2007; 178(7): 4184 - 4193. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Del Prete, W.-H. Shao, S. Mitola, G. Santoro, S. Sozzani, and B. Haribabu Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function Blood, January 15, 2007; 109(2): 626 - 631. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Braun, L. Galibert, T. Nakajima, H. Saito, V. V. Quang, M. Rubio, and M. Sarfati Semimature Stage: A Checkpoint in a Dendritic Cell Maturation Program That Allows for Functional Reversion after Signal-Regulatory Protein-{alpha} Ligation and Maturation Signals J. Immunol., December 15, 2006; 177(12): 8550 - 8559. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. O. Martinez, S. Gordon, M. Locati, and A. Mantovani Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression J. Immunol., November 15, 2006; 177(10): 7303 - 7311. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Velan, E. Bar-Haim, A. Zauberman, E. Mamroud, A. Shafferman, and S. Cohen Discordance in the Effects of Yersinia pestis on the Dendritic Cell Functions Manifested by Induction of Maturation and Paralysis of Migration Infect. Immun., November 1, 2006; 74(11): 6365 - 6376. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Cappello, T. Fraone, L. Barberis, C. Costa, E. Hirsch, A. R. Elia, C. Caorsi, T. Musso, F. Novelli, and M. Giovarelli CC-Chemokine Ligand 16 Induces a Novel Maturation Program in Human Immature Monocyte-Derived Dendritic Cells J. Immunol., November 1, 2006; 177(9): 6143 - 6151. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Otero, M. Groettrup, and D. F. Legler Opposite Fate of Endocytosed CCR7 and Its Ligands: Recycling versus Degradation J. Immunol., August 15, 2006; 177(4): 2314 - 2323. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Dauer, K. Schad, J. Junkmann, C. Bauer, J. Herten, R. Kiefl, M. Schnurr, S. Endres, and A. Eigler IFN-{alpha} promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4 J. Leukoc. Biol., August 1, 2006; 80(2): 278 - 286. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Alfonso-Perez, S. Lopez-Giral, N. E. Quintana, J. Loscertales, P. Martin-Jimenez, and C. Munoz Anti-CCR7 monoclonal antibodies as a novel tool for the treatment of chronic lymphocyte leukemia J. Leukoc. Biol., June 1, 2006; 79(6): 1157 - 1165. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Sanchez-Sanchez, L. Riol-Blanco, and J. L. Rodriguez-Fernandez The Multiple Personalities of the Chemokine Receptor CCR7 in Dendritic Cells J. Immunol., May 1, 2006; 176(9): 5153 - 5159. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Zhou, Y. Luo, C. D. Kaplan, J. A. Kruger, S.-H. Lee, R. Xiang, and R. A. Reisfeld A DNA-based cancer vaccine enhances lymphocyte cross talk by engaging the NKG2D receptor Blood, April 15, 2006; 107(8): 3251 - 3257. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Doni, M. Michela, B. Bottazzi, G. Peri, S. Valentino, N. Polentarutti, C. Garlanda, and A. Mantovani Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-{gamma} J. Leukoc. Biol., April 1, 2006; 79(4): 797 - 802. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Piqueras, J. Connolly, H. Freitas, A. K. Palucka, and J. Banchereau Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors Blood, April 1, 2006; 107(7): 2613 - 2618. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. von Bergwelt-Baildon, A. Shimabukuro-Vornhagen, A. Popov, N. Klein-Gonzalez, F. Fiore, S. Debey, A. Draube, B. Maecker, I. Menezes, L. M. Nadler, et al. CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants Blood, April 1, 2006; 107(7): 2786 - 2789. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Cao, P. Tan, C. H. Lee, H. Zhang, and J. Lu A transforming growth factor-beta-induced protein stimulates endocytosis and is up-regulated in immature dendritic cells Blood, April 1, 2006; 107(7): 2777 - 2785. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Trogan, J. E. Feig, S. Dogan, G. H. Rothblat, V. Angeli, F. Tacke, G. J. Randolph, and E. A. Fisher Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. PNAS, March 7, 2006; 103(10): 3781 - 3786. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. F. Legler, P. Krause, E. Scandella, E. Singer, and M. Groettrup Prostaglandin E2 Is Generally Required for Human Dendritic Cell Migration and Exerts Its Effect via EP2 and EP4 Receptors J. Immunol., January 15, 2006; 176(2): 966 - 973. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. A. Islam, S. Y. Thomas, C. Hess, B. D. Medoff, T. K. Means, C. Brander, C. M. Lilly, A. M. Tager, and A. D. Luster The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans Blood, January 15, 2006; 107(2): 444 - 453. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Vermi, F. Facchetti, E. Riboldi, H. Heine, S. Scutera, S. Stornello, D. Ravarino, P. Cappello, M. Giovarelli, R. Badolato, et al. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma Blood, January 15, 2006; 107(2): 454 - 462. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Hatterer, N. Davoust, M. Didier-Bazes, C. Vuaillat, C. Malcus, M.-F. Belin, and S. Nataf How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes Blood, January 15, 2006; 107(2): 806 - 812. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Rimoldi, M. Chieppa, P. Larghi, M. Vulcano, P. Allavena, and M. Rescigno Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different Blood, October 15, 2005; 106(8): 2818 - 2826. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. W. DePaolo, R. Lathan, B. J. Rollins, and W. J. Karpus The Chemokine CCL2 Is Required for Control of Murine Gastric Salmonella enterica Infection Infect. Immun., October 1, 2005; 73(10): 6514 - 6522. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Vermaelen and R. Pauwels Pulmonary Dendritic Cells Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 530 - 551. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. T. Prechtel, N. M. Turza, D. J. Kobelt, J. I. Eisemann, R. S. Coffin, Y. McGrath, C. Hacker, X. Ju, M. Zenke, and A. Steinkasserer Infection of mature dendritic cells with herpes simplex virus type 1 dramatically reduces lymphoid chemokine-mediated migration J. Gen. Virol., June 1, 2005; 86(6): 1645 - 1657. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. A. Efron, H. Tsujimoto, F. R. Bahjat, R. Ungaro, J. Debernardis, C. Tannahill, H. V. Baker, C. K. Edwards, and L. L. Moldawer Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-{alpha} Innate Immunity, June 1, 2005; 11(3): 145 - 160. [Abstract] [PDF] |
||||
![]() |
S. Paoletti, V. Petkovic, S. Sebastiani, M. G. Danelon, M. Uguccioni, and B. O. Gerber A rich chemokine environment strongly enhances leukocyte migration and activities Blood, May 1, 2005; 105(9): 3405 - 3412. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Lagaraine, C. Hoarau, V. Chabot, F. Velge-Roussel, and Y. Lebranchu Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways Int. Immunol., April 1, 2005; 17(4): 351 - 363. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Iizasa, H. Yoneyama, N. Mukaida, Y. Katakoka, M. Naito, N. Yoshida, E. Nakashima, and K. Matsushima Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production J. Immunol., March 15, 2005; 174(6): 3273 - 3280. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. de Noronha, S. Hardy, J. Sinclair, M. P. Blundell, J. Strid, O. Schulz, J. Zwirner, G. E. Jones, D. R. Katz, C. Kinnon, et al. Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein Blood, February 15, 2005; 105(4): 1590 - 1597. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Varani, G. Frascaroli, M. Homman-Loudiyi, S. Feld, M. P. Landini, and C. Soderberg-Naucler Human cytomegalovirus inhibits the migration of immature dendritic cells by down-regulating cell-surface CCR1 and CCR5 J. Leukoc. Biol., February 1, 2005; 77(2): 219 - 228. [Abstract] [Full Text] [PDF] |
||||
![]() |
B.-C. Chiu, C. M. Freeman, V. R. Stolberg, J. S. Hu, K. Zeibecoglou, B. Lu, C. Gerard, I. F. Charo, S. A. Lira, and S. W. Chensue Impaired Lung Dendritic Cell Activation in CCR2 Knockout Mice Am. J. Pathol., October 1, 2004; 165(4): 1199 - 1209. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Avigan Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma Clin. Cancer Res., September 15, 2004; 10(18): 6347S - 6352S. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. L. W. Chang, N. Baumgarth, D. Yu, and P. A. Barry Human Cytomegalovirus-Encoded Interleukin-10 Homolog Inhibits Maturation of Dendritic Cells and Alters Their Functionality J. Virol., August 15, 2004; 78(16): 8720 - 8731. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Ritter, F. Wiede, D. Mielenz, Z. Kiafard, J. Zwirner, and H. Korner Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells J. Leukoc. Biol., August 1, 2004; 76(2): 472 - 476. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Sanchez-Sanchez, L. Riol-Blanco, G. de la Rosa, A. Puig-Kroger, J. Garcia-Bordas, D. Martin, N. Longo, A. Cuadrado, C. Cabanas, A. L. Corbi, et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells Blood, August 1, 2004; 104(3): 619 - 625. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. D'Amico, M. Vulcano, C. Bugarin, G. Bianchi, G. Pirovano, M. Bonamino, V. Marin, P. Allavena, E. Biagi, and A. Biondi CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy Blood, August 1, 2004; 104(3): 744 - 751. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-C. Yang, S. Hillinger, K. Riedl, L. Zhang, L. Zhu, M. Huang, K. Atianzar, B. Y. Kuo, B. Gardner, R. K. Batra, et al. Intratumoral Administration of Dendritic Cells Overexpressing CCL21 Generates Systemic Antitumor Responses and Confers Tumor Immunity Clin. Cancer Res., April 15, 2004; 10(8): 2891 - 2901. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Moutaftsi, P. Brennan, S. A. Spector, and Z. Tabi Impaired Lymphoid Chemokine-Mediated Migration due to a Block on the Chemokine Receptor Switch in Human Cytomegalovirus-Infected Dendritic Cells J. Virol., March 15, 2004; 78(6): 3046 - 3054. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Baize, J. Kaplon, C. Faure, D. Pannetier, M.-C. Georges-Courbot, and V. Deubel Lassa Virus Infection of Human Dendritic Cells and Macrophages Is Productive but Fails to Activate Cells J. Immunol., March 1, 2004; 172(5): 2861 - 2869. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Guo, M. Zhang, H. An, W. Chen, S. Liu, J. Guo, Y. Yu, and X. Cao Fas ligation induces IL-1{beta}-dependent maturation and IL-1{beta}-independent survival of dendritic cells: different roles of ERK and NF-{kappa}B signaling pathways Blood, December 15, 2003; 102(13): 4441 - 4447. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Russo, B. Bussolati, I. Deambrosis, F. Mariano, and G. Camussi Platelet-Activating Factor Mediates CD40-Dependent Angiogenesis and Endothelial-Smooth Muscle Cell Interaction J. Immunol., November 15, 2003; 171(10): 5489 - 5497. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Jing, E. Vassiliou, and D. Ganea Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells J. Leukoc. Biol., November 1, 2003; 74(5): 868 - 879. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Chieppa, G. Bianchi, A. Doni, A. Del Prete, M. Sironi, G. Laskarin, P. Monti, L. Piemonti, A. Biondi, A. Mantovani, et al. Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program J. Immunol., November 1, 2003; 171(9): 4552 - 4560. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Wittamer, J.-D. Franssen, M. Vulcano, J.-F. Mirjolet, E. Le Poul, I. Migeotte, S. Brezillon, R. Tyldesley, C. Blanpain, M. Detheux, et al. Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids J. Exp. Med., October 6, 2003; 198(7): 977 - 985. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Matsuyama, M. Faure, and T. Yoshimura Activation of Discoidin Domain Receptor 1 Facilitates the Maturation of Human Monocyte-Derived Dendritic Cells Through the TNF Receptor Associated Factor 6/TGF-{beta}-Activated Protein Kinase 1 Binding Protein 1{beta}/p38{alpha} Mitogen-Activated Protein Kinase Signaling Cascade J. Immunol., October 1, 2003; 171(7): 3520 - 3532. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Grolleau, D. E. Misek, R. Kuick, S. Hanash, and J. J. Mule Inducible Expression of Macrophage Receptor Marco by Dendritic Cells Following Phagocytic Uptake of Dead Cells Uncovered by Oligonucleotide Arrays J. Immunol., September 15, 2003; 171(6): 2879 - 2888. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Jefford, M. Schnurr, T. Toy, K.-A. Masterman, A. Shin, T. Beecroft, T. Y. Tai, K. Shortman, M. Shackleton, I. D. Davis, et al. Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli Blood, September 1, 2003; 102(5): 1753 - 1763. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Skelton, M. Cooper, M. Murphy, and A. Platt Human Immature Monocyte-Derived Dendritic Cells Express the G Protein-Coupled Receptor GPR105 (KIAA0001, P2Y14) and Increase Intracellular Calcium in Response to its Agonist, Uridine Diphosphoglucose J. Immunol., August 15, 2003; 171(4): 1941 - 1949. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. E. Annels, C. E.T. da Costa, F. A. Prins, A. Willemze, P. C.W. Hogendoorn, and R. M. Egeler Aberrant Chemokine Receptor Expression and Chemokine Production by Langerhans Cells Underlies the Pathogenesis of Langerhans Cell Histiocytosis J. Exp. Med., May 19, 2003; 197(10): 1385 - 1390. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. de la Rosa, N. Longo, J. L. Rodriguez-Fernandez, A. Puig-Kroger, A. Pineda, A. L. Corbi, and P. Sanchez-Mateos Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration J. Leukoc. Biol., May 1, 2003; 73(5): 639 - 649. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. TURECI, H. BIAN, F. O. NESTLE, L. RADDRIZZANI, J. A. ROSINSKI, A. TASSIS, H. HILTON, M. WALSTEAD, U. SAHIN, and J. HAMMER Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis FASEB J, May 1, 2003; 17(8): 836 - 847. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Dauer, B. Obermaier, J. Herten, C. Haerle, K. Pohl, S. Rothenfusser, M. Schnurr, S. Endres, and A. Eigler Mature Dendritic Cells Derived from Human Monocytes Within 48 Hours: A Novel Strategy for Dendritic Cell Differentiation from Blood Precursors J. Immunol., April 15, 2003; 170(8): 4069 - 4076. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Schlienger, C. S. Chu, E. Y. Woo, P. M. Rivers, A. J. Toll, B. Hudson, M. V. Maus, J. L. Riley, Y. Choi, G. Coukos, et al. TRANCE- and CD40 Ligand-matured Dendritic Cells Reveal MHC Class I-restricted T Cells Specific for Autologous Tumor in Late-Stage Ovarian Cancer Patients Clin. Cancer Res., April 1, 2003; 9(4): 1517 - 1527. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Vulcano, S. Struyf, P. Scapini, M. Cassatella, S. Bernasconi, R. Bonecchi, A. Calleri, G. Penna, L. Adorini, W. Luini, et al. Unique Regulation of CCL18 Production by Maturing Dendritic Cells J. Immunol., April 1, 2003; 170(7): 3843 - 3849. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. D. Fleming, J. L. Pinkus, S. W. Alexander, C. Tam, M. Loda, S. E. Sallan, K. E. Nichols, D. F. Carpentieri, G. S. Pinkus, and B. J. Rollins Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis Blood, April 1, 2003; 101(7): 2473 - 2475. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Vuckovic, M. Kim, D. Khalil, C. J. Turtle, G. V. Crosbie, N. Williams, L. Brown, K. Williams, C. Kelly, P. Stravos, et al. Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression Blood, March 15, 2003; 101(6): 2314 - 2317. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Abe, F. O. Yarovinsky, T. Murakami, A. N. Shakhov, A. V. Tumanov, D. Ito, L. N. Drutskaya, K. Pfeffer, D. V. Kuprash, K. L. Komschlies, et al. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo Blood, February 15, 2003; 101(4): 1477 - 1483. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nakae, Y. Komiyama, S. Narumi, K. Sudo, R. Horai, Y.-i. Tagawa, K. Sekikawa, K. Matsushima, M. Asano, and Y. Iwakura IL-1-induced tumor necrosis factor-{alpha} elicits inflammatory cell infiltration in the skin by inducing IFN-{gamma}-inducible protein 10 in the elicitation phase of the contact hypersensitivity response Int. Immunol., February 1, 2003; 15(2): 251 - 260. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Ferrero, D. Belloni, P. Contini, C. Foglieni, M. E. Ferrero, M. Fabbri, A. Poggi, and M. R. Zocchi Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation Blood, January 1, 2003; 101(1): 186 - 193. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Verbovetski, H. Bychkov, U. Trahtemberg, I. Shapira, M. Hareuveni, O. Ben-Tal, I. Kutikov, O. Gill, and D. Mevorach Opsonization of Apoptotic Cells by Autologous iC3b Facilitates Clearance by Immature Dendritic Cells, Down-regulates DR and CD86, and Up-regulates CC Chemokine Receptor 7 J. Exp. Med., December 16, 2002; 196(12): 1553 - 1561. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Weigel, N. Nath, P. A. Taylor, A. Panoskaltsis-Mortari, W. Chen, A. M. Krieg, K. Brasel, and B. R. Blazar Comparative analysis of murine marrow-derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo induction of antileukemia responses Blood, December 1, 2002; 100(12): 4169 - 4176. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Tolba, W. J. Bowers, J. Muller, V. Housekneckt, R. E. Giuliano, H. J. Federoff, and J. D. Rosenblatt Herpes Simplex Virus (HSV) Amplicon-mediated Codelivery of Secondary Lymphoid Tissue Chemokine and CD40L Results in Augmented Antitumor Activity Cancer Res., November 15, 2002; 62(22): 6545 - 6551. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Messmer, J.-M. Jacque, C. Santisteban, C. Bristow, S.-Y. Han, L. Villamide-Herrera, E. Mehlhop, P. A. Marx, R. M. Steinman, A. Gettie, et al. Endogenously Expressed nef Uncouples Cytokine and Chemokine Production from Membrane Phenotypic Maturation in Dendritic Cells J. Immunol., October 15, 2002; 169(8): 4172 - 4182. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Cui, Y. Le, H. Yazawa, W. Gong, and J. M. Wang Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease J. Leukoc. Biol., October 1, 2002; 72(4): 628 - 635. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Matsue, C. Yang, K. Matsue, D. Edelbaum, M. Mummert, and A. Takashima Contrasting Impacts of Immunosuppressive Agents (Rapamycin, FK506, Cyclosporin A, and Dexamethasone) on Bidirectional Dendritic Cell-T Cell Interaction During Antigen Presentation J. Immunol., October 1, 2002; 169(7): 3555 - 3564. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Beaulieu, D. F. Robbiani, X. Du, E. Rodrigues, R. Ignatius, Y. Wei, P. Ponath, J. W. Young, M. Pope, R. M. Steinman, et al. Expression of a Functional Eotaxin (CC Chemokine Ligand 11) Receptor CCR3 by Human Dendritic Cells J. Immunol., September 15, 2002; 169(6): 2925 - 2936. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Scandella, Y. Men, S. Gillessen, R. Forster, and M. Groettrup Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells Blood, July 30, 2002; 100(4): 1354 - 1361. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Idzko, S. Dichmann, D. Ferrari, F. Di Virgilio, A. la Sala, G. Girolomoni, E. Panther, and J. Norgauer Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors Blood, July 18, 2002; 100(3): 925 - 932. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. D. Richters, I. Mayen, C. E. G. Havenith, R. H. J. Beelen, and E. W. A. Kamperdijk Rat monocyte-derived dendritic cells function and migrate in the same way as isolated tissue dendritic cells J. Leukoc. Biol., April 1, 2002; 71(4): 582 - 587. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. la Sala, S. Sebastiani, D. Ferrari, F. Di Virgilio, M. Idzko, J. Norgauer, and G. Girolomoni Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes Blood, March 1, 2002; 99(5): 1715 - 1722. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-H. Cui, Y. Le, W. Gong, P. Proost, J. Van Damme, W. J. Murphy, and J. M. Wang Bacterial Lipopolysaccharide Selectively Up-Regulates the Function of the Chemotactic Peptide Receptor Formyl Peptide Receptor 2 in Murine Microglial Cells J. Immunol., January 1, 2002; 168(1): 434 - 442. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Parlato, S. M. Santini, C. Lapenta, T. Di Pucchio, M. Logozzi, M. Spada, A. M. Giammarioli, W. Malorni, S. Fais, and F. Belardelli Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities Blood, November 15, 2001; 98(10): 3022 - 3029. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bouchon, C. Hernandez-Munain, M. Cella, and M. Colonna A Dap12-Mediated Pathway Regulates Expression of Cc Chemokine Receptor 7 and Maturation of Human Dendritic Cells J. Exp. Med., October 15, 2001; 194(8): 1111 - 1122. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Sharma, M. Stolina, L. Zhu, Y. Lin, R. Batra, M. Huang, R. Strieter, and S. M. Dubinett Secondary Lymphoid Organ Chemokine Reduces Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma Cancer Res., September 1, 2001; 61(17): 6406 - 6412. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. PANTHER, M. IDZKO, Y. HEROUY, H. RHEINEN, P. J. GEBICKE-HAERTER, U. MROWIETZ, S. DICHMANN, and J. NORGAUER Expression and function of adenosine receptors in human dendritic cells FASEB J, September 1, 2001; 15(11): 1963 - 1970. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Penna, S. Sozzani, and L. Adorini Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells J. Immunol., August 15, 2001; 167(4): 1862 - 1866. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-A. Kellermann and L. M. McEvoy The Peyer's Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli J. Immunol., July 15, 2001; 167(2): 682 - 690. [Abstract] [Full Text] [PDF] |
||||
![]() |
G.B. Toews Cytokines and the lung Eur. Respir. J., July 2, 2001; 18(34_suppl): 3S - 17s. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Takayama, A. E. Morelli, N. Onai, M. Hirao, K. Matsushima, H. Tahara, and A. W. Thomson Mammalian and Viral IL-10 Enhance C-C Chemokine Receptor 5 but Down-Regulate C-C Chemokine Receptor 7 Expression by Myeloid Dendritic Cells: Impact on Chemotactic Responses and In Vivo Homing Ability J. Immunol., June 15, 2001; 166(12): 7136 - 7143. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |