| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa College of Medicine, and Veterans Administrations Medical Center, Iowa City, IA 52242
Hypersensitivity pneumonitis (HP) is a granulomatous, inflammatory
lung disease caused by inhalation of organic Ags, most commonly
thermophilic actinomycetes. Only a minority of individuals exposed to
these Ags develops disease, suggesting that host factors are important
for the expression of HP. We compared the expression of HP in a
sensitive strain of mice, C57BL/6, and in a resistant strain of mice,
DBA/2. They were exposed to the thermophilic bacteria
Saccharopolyspora rectivirgula (SR) or to saline alone for
3 consecutive days/week for 3 wk. After exposure to Ag, C57BL/6 mice,
but not DBA/2 mice, developed granulomatous inflammation with an
increase in lung index (lung weight). Both strains had similar amounts
of Ag delivered to the lungs after intranasal installation, as
determined with 14C-labeled Ag. Both also had similar
increases in total bronchoalveolar cells after Ag exposure, but the
C57BL/6 mice had more lymphocytes. Compared with the resistant strain,
the sensitive strain had a significantly greater Ag-induced increase in
IL-12 and IFN-
gene expression. DBA/2 mice resembled sensitive,
C57BL/6 mice if they received IL-12 augmentation therapy at the time of
Ag exposure. These findings were not limited to lung, since both
unstimulated and SR-stimulated spleen cells from C57BL/6 mice released
significantly more IL-12 than cells from DBA/2 mice. However, spleen
cells from DBA/2 mice made more IFN- when exposed to IL-12, than
cells from C57BL/6 mice. These results suggest that the IL-12 response
to Ag may modulate in part the expression of HP.
This article has been cited by other articles:
|
|
 |
|
  Y. Park, S. J. Oh, and D. H. Chung CD4+CD25+ regulatory T cells attenuate hypersensitivity pneumonitis by suppressing IFN-{gamma} production by CD4+ and CD8+ T cells J. Leukoc. Biol., December 1, 2009; 86(6): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Joshi, D. J. Fong, S. R. Oak, G. Trujillo, K. R. Flaherty, F. J. Martinez, and C. M. Hogaboam Interleukin-17-mediated Immunopathogenesis in Experimental Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 705 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Simonian, C. L. Roark, F. Wehrmann, A. K. Lanham, F. Diaz del Valle, W. K. Born, R. L. O'Brien, and A. P. Fontenot Th17-Polarized Immune Response in a Murine Model of Hypersensitivity Pneumonitis and Lung Fibrosis J. Immunol., January 1, 2009; 182(1): 657 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bogaert, K. G. Tournoy, T. Naessens, and J. Grooten Where Asthma and Hypersensitivity Pneumonitis Meet and Differ: Noneosinophilic Severe Asthma Am. J. Pathol., January 1, 2009; 174(1): 3 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Kishi, Y Miyazaki, T Jinta, H Furusawa, Y Ohtani, N Inase, and Y Yoshizawa Pathogenesis of cBFL in common with IPF? Correlation of IP-10/TARC ratio with histological patterns Thorax, September 1, 2008; 63(9): 810 - 816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Kugathasan, L J Saubermann, L Smith, D Kou, J Itoh, D G Binion, A D Levine, R S Blumberg, and C Fiocchi Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease Gut, December 1, 2007; 56(12): 1696 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Misra, H. Lee, A. Singh, K. Huang, R. K. Thimmulappa, W. Mitzner, S. Biswal, and C. G. Tankersley Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes Physiol Genomics, November 14, 2007; 31(3): 429 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Korosec, K. Osolnik, I. Kern, M. Silar, K. Mohorcic, and M. Kosnik Expansion of Pulmonary CD8+CD56+ Natural Killer T-Cells in Hypersensitivity Pneumonitis Chest, October 1, 2007; 132(4): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Hwang, S. Kim, W. S. Park, and D. H. Chung IL-4-Secreting NKT Cells Prevent Hypersensitivity Pneumonitis by Suppressing IFN-{gamma}-Producing Neutrophils J. Immunol., October 15, 2006; 177(8): 5258 - 5268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Thorne, A. Adamcakova-Dodd, K. M. Kelly, M. E. O'Neill, and C. Duchaine Metalworking Fluid with Mycobacteria and Endotoxin Induces Hypersensitivity Pneumonitis in Mice Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 759 - 768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Kim, H. Y. Kim, B. K. Kim, S. Kim, and D. H. Chung Engagement of Glucocorticoid-Induced TNF Receptor Costimulates NKT Cell Activation In Vitro and In Vivo J. Immunol., March 15, 2006; 176(6): 3507 - 3515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Fink, H. G. Ortega, H. Y. Reynolds, Y. F. Cormier, L. L. Fan, T. J. Franks, K. Kreiss, S. Kunkel, D. Lynch, S. Quirce, et al. Needs and Opportunities for Research in Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 792 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Morris Gold, Silver, and Bronze: Metals, Medals, and Standards in Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 909 - 910. [Full Text] [PDF]
|
|
|
|
|
|
Y. Matsunaga, Y. Usui, and Y. Yoshizawa TA-19, a Novel Protein Antigen of Trichosporon asahii, in Summer-type Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., April 1, 2003; 167(7): 991 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Butler, M. M. Monick, T. O. Yarovinsky, L. S. Powers, and G. W. Hunninghake Altered IL-4 mRNA Stability Correlates with Th1 and Th2 Bias and Susceptibility to Hypersensitivity Pneumonitis in Two Inbred Strains of Mice J. Immunol., October 1, 2002; 169(7): 3700 - 3709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Todt, J. Sonstein, T. Polak, G. D. Seitzman, B. Hu, and J. L. Curtis Repeated Intratracheal Challenge with Particulate Antigen Modulates Murine Lung Cytokines ,2 J. Immunol., April 15, 2000; 164(8): 4037 - 4047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Israel-Assayag, M. Fournier, and Y. Cormier Blockade of T Cell Costimulation by CTLA4-Ig Inhibits Lung Inflammation in Murine Hypersensitivity Pneumonitis J. Immunol., December 15, 1999; 163(12): 6794 - 6799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamasaki, M. Ando, W. Brazer, D. M. Center, and W. W. Cruikshank Polarized Type 1 Cytokine Profile in Bronchoalveolar Lavage T Cells of Patients with Hypersensitivity Pneumonitis J. Immunol., September 15, 1999; 163(6): 3516 - 3523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gudmundsson, M. M. Monick, and G. W. Hunninghake Viral Infection Modulates Expression of Hypersensitivity Pneumonitis J. Immunol., June 15, 1999; 162(12): 7397 - 7401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. ISRAËL-ASSAYAG, A. DAKHAMA, S. LAVIGNE, M. LAVIOLETTE, and Y. CORMIER Expression of Costimulatory Molecules on Alveolar Macrophages in Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1830 - 1834. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
