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*
Department of Immunology, Lerner Research Institute; and Departments of
Hematology-Oncology and
Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195
The role of the non-ELR-containing CXC chemokines IP-10 and Mig in
antitumor activity induced by systemic treatment with IL-12 was
examined in mice bearing the murine renal adenocarcinoma RENCA. IL-12
treatment produces a potent antitumor effect that is associated with
tumor infiltration by CD8+ T lymphocytes. The
regression of tumor is associated with the elevated expression of the
IFN-
-inducible chemokines IP-10 and Mig within the tumor tissue.
IP-10 and Mig have been shown to function as chemoattractants for
activated T lymphocytes. In animals treated with rabbit polyclonal Abs
specific for IP-10 and for Mig, the IL-12-induced regression of RENCA
tumors was partially abrogated. This effect was associated with a
dramatic inhibition of T cell infiltration. Thus, it appears that
IL-12-dependent, T cell-mediated antitumor activity requires the
intermediate expression of IP-10 and Mig to recruit antitumor effector
T cells to the tumor site.
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S. J. Ha, C. H. Lee, S. B. Lee, C. M. Kim, K. L. Jang, H. S. Shin, and Y. C. Sung A Novel Function of IL-12p40 as a Chemotactic Molecule for Macrophages J. Immunol., September 1, 1999; 163(5): 2902 - 2908. [Abstract] [Full Text] [PDF]
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