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The Journal of Immunology, 1998, 161: 927-932.
Copyright © 1998 by The American Association of Immunologists

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor1

Charles S. Tannenbaum2,*, Raymond Tubbs*,{ddagger}, David Armstrong*, James H. Finke*, Ronald M. Bukowski*,{dagger} and Thomas A. Hamilton*

* Department of Immunology, Lerner Research Institute; and Departments of {dagger} Hematology-Oncology and {ddagger} Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195

The role of the non-ELR-containing CXC chemokines IP-10 and Mig in antitumor activity induced by systemic treatment with IL-12 was examined in mice bearing the murine renal adenocarcinoma RENCA. IL-12 treatment produces a potent antitumor effect that is associated with tumor infiltration by CD8+ T lymphocytes. The regression of tumor is associated with the elevated expression of the IFN-{gamma}-inducible chemokines IP-10 and Mig within the tumor tissue. IP-10 and Mig have been shown to function as chemoattractants for activated T lymphocytes. In animals treated with rabbit polyclonal Abs specific for IP-10 and for Mig, the IL-12-induced regression of RENCA tumors was partially abrogated. This effect was associated with a dramatic inhibition of T cell infiltration. Thus, it appears that IL-12-dependent, T cell-mediated antitumor activity requires the intermediate expression of IP-10 and Mig to recruit antitumor effector T cells to the tumor site.




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B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR {alpha}-chemokine
Int. Immunol., May 1, 2000; 12(5): 677 - 689.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. Sharma, M. Stolina, J. Luo, R. M. Strieter, M. Burdick, L. X. Zhu, R. K. Batra, and S. M. Dubinett
Secondary Lymphoid Tissue Chemokine Mediates T Cell-Dependent Antitumor Responses In Vivo
J. Immunol., May 1, 2000; 164(9): 4558 - 4563.
[Abstract] [Full Text] [PDF]


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BloodHome page
K. Dunussi-Joannopoulos, K. Runyon, J. Erickson, R. G. Schaub, R. G. Hawley, and J. P. Leonard
Vaccines With Interleukin-12-Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity
Blood, December 15, 1999; 94(12): 4263 - 4273.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
R. M. Bukowski, P. Rayman, L. Molto, C. S. Tannenbaum, T. Olencki, D. Peereboom, R. Tubbs, D. McLain, G. T. Budd, T. Griffin, et al.
Interferon-{{gamma}} and CXC Chemokine Induction by Interleukin 12 in Renal Cell Carcinoma
Clin. Cancer Res., October 1, 1999; 5(10): 2780 - 2789.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
S. J. Ha, C. H. Lee, S. B. Lee, C. M. Kim, K. L. Jang, H. S. Shin, and Y. C. Sung
A Novel Function of IL-12p40 as a Chemotactic Molecule for Macrophages
J. Immunol., September 1, 1999; 163(5): 2902 - 2908.
[Abstract] [Full Text] [PDF]


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JEMHome page
S. E. Pike, L. Yao, K. D. Jones, B. Cherney, E. Appella, K. Sakaguchi, H. Nakhasi, J. Teruya-Feldstein, P. Wirth, G. Gupta, et al.
Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth
J. Exp. Med., December 21, 1998; 188(12): 2349 - 2356.
[Abstract] [Full Text] [PDF]




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