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Mapping Quantitative Trait Loci for Immune Capacity in the Pig¹

Inger Edfors-Lilja^2,*,, Eva Wattrang^3,, Lena Marklund, Maria Moller, Lena Andersson-Eklund, Leif Andersson and Caroline Fossum

^* Department of Engineering and Natural Sciences, University of Växjö, Växjö, Sweden; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden; and Department of Veterinary Microbiology, Division of Immunology, Swedish University of Agricultural Sciences, Uppsala, Sweden

Immune capacity traits show considerable genetic variation in outbred populations. To identify quantitative trait loci (QTLs) for immune capacity in the pig, various measures of immune function (total and differential leukocyte counts, neutrophil phagocytosis, mitogen-induced proliferation, IL-2 production, and virus induced IFN- production in whole blood cultures, and Ab responses to two Escherichia coli antigens) were determined in 200 F₂ animals from a wild pig–Swedish Yorkshire intercross. The pedigree has been typed for 236 genetic markers covering all autosomes, the X chromosome and the X/Y pseudoautosomal region. Through interval mapping using a least-squares method, four QTLs with significant effects were identified; one for total leukocyte counts, one for mitogen-induced proliferation, one for prevaccination levels of Abs to E. coli Ag K88, and one for Ab response to the O149 Ag. In addition, several putative QTLs were indicated. The results from the present study conclusively show that it is possible to identify QTLs for immune capacity traits in outbred pig populations by genome analysis.

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