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CUTTING EDGE |
*
Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy;
Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304;
Department of Experimental Medicine and Pathology, University of Rome, "La Sapienza", Rome, Italy;
§
Department of Genetics, University of Bari, Bari, Italy;
¶
Laboratory of Vascular Pathology, Istituto Dermopatico dell’Immacolata, Rome, Italy; and
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Roche Institute, Milan, Italy
In this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found most abundantly expressed in activated Th2-polarized cells and in NK1.1+CD4+ T cells. Human CCR8 is also preferentially expressed in human Th2-polarized cells and clones. This pattern of expression suggests that CCR8 is part of a Th2-specific gene expression program. The CCR8 ligands I-309 and its mouse homologue T cell activation gene 3 (TCA-3) are potent chemoattractants for Th2-polarized cells. Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases.
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O. Fahy, S. Senechal, J. Pene, A. Scherpereel, P. Lassalle, A.-B. Tonnel, H. Yssel, B. Wallaert, and A. Tsicopoulos Diesel Exposure Favors Th2 Cell Recruitment by Mononuclear Cells and Alveolar Macrophages from Allergic Patients by Differentially Regulating Macrophage-Derived Chemokine and IFN-{gamma}-Induced Protein-10 Production J. Immunol., June 1, 2002; 168(11): 5912 - 5919. [Abstract] [Full Text] [PDF]
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A. la Sala, S. Sebastiani, D. Ferrari, F. Di Virgilio, M. Idzko, J. Norgauer, and G. Girolomoni Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes Blood, March 1, 2002; 99(5): 1715 - 1722. [Abstract] [Full Text] [PDF]
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M. K. Park, K. F. Hoffmann, A. W. Cheever, D. Amichay, T. A. Wynn, and J. M. Farber Patterns of Chemokine Expression in Models of Schistosoma mansoni Inflammation and Infection Reveal Relationships between Type 1 and Type 2 Responses and Chemokines In Vivo Infect. Immun., November 1, 2001; 69(11): 6755 - 6768. [Abstract] [Full Text] [PDF]
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M. Mack, J. Cihak, C. Simonis, B. Luckow, A. E. I. Proudfoot, H. Bruhl, M. Frink, H.-J. Anders, V. Vielhauer, J. Pfirstinger, et al. Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice J. Immunol., April 1, 2001; 166(7): 4697 - 4704. [Abstract] [Full Text] [PDF]
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S. W. Chensue, N. W. Lukacs, T.-Y. Yang, X. Shang, K. A. Frait, S. L. Kunkel, T. Kung, M. T. Wiekowski, J. A. Hedrick, D. N. Cook, et al. Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice J. Exp. Med., March 5, 2001; 193(5): 573 - 584. [Abstract] [Full Text] [PDF]
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H. Bruhl, J. Cihak, M. Stangassinger, D. Schlondorff, and M. Mack Depletion of CCR5-Expressing Cells with Bispecific Antibodies and Chemokine Toxins: A New Strategy in the Treatment of Chronic Inflammatory Diseases and HIV J. Immunol., February 15, 2001; 166(4): 2420 - 2426. [Abstract] [Full Text] [PDF]
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R. E. Wiley, K. Palmer, B. U. Gajewska, M. R. Stampfli, D. Alvarez, A. J. Coyle, J.-C. Gutierrez-Ramos, and M. Jordana Expression of the Th1 Chemokine IFN-{{gamma}}-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice J. Immunol., February 15, 2001; 166(4): 2750 - 2759. [Abstract] [Full Text] [PDF]
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M. M. Fort, R. Lesley, N. J. Davidson, S. Menon, F. Brombacher, M. W. Leach, and D. M. Rennick IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis J. Immunol., February 15, 2001; 166(4): 2793 - 2800. [Abstract] [Full Text] [PDF]
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S. Sebastiani, P. Allavena, C. Albanesi, F. Nasorri, G. Bianchi, C. Traidl, S. Sozzani, G. Girolomoni, and A. Cavani Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity J. Immunol., January 15, 2001; 166(2): 996 - 1002. [Abstract] [Full Text] [PDF]
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D. P. Andrew, N. Ruffing, C. H. Kim, W. Miao, H. Heath, Y. Li, K. Murphy, J. J. Campbell, E. C. Butcher, and L. Wu C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential J. Immunol., January 1, 2001; 166(1): 103 - 111. [Abstract] [Full Text] [PDF]
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L. Kremer, L. Carramolino, I. Goya, A. Zaballos, J. Gutierrez, M. del Carmen Moreno-Ortiz, C. Martinez-A., and G. Marquez The Transient Expression of C-C Chemokine Receptor 8 in Thymus Identifies a Thymocyte Subset Committed to Become CD4+ Single-Positive T Cells J. Immunol., January 1, 2001; 166(1): 218 - 225. [Abstract] [Full Text] [PDF]
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N. S. Haque, J. T. Fallon, M. B. Taubman, and P. C. Harpel The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium Blood, January 1, 2001; 97(1): 39 - 45. [Abstract] [Full Text] [PDF]
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J. Yamamoto, Y. Adachi, Y. Onoue, Y. S. Adachi, Y. Okabe, T. Itazawa, M. Toyoda, T. Seki, M. Morohashi, K. Matsushima, et al. Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells J. Leukoc. Biol., October 1, 2000; 68(4): 568 - 574. [Abstract] [Full Text]
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F. SINIGAGLIA and D. D'AMBROSIO Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S157 - 160. [Abstract] [Full Text] [PDF]
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 Y. C. Q. Zang, A. K. Samanta, J. B. Halder, J. Hong, M. V. Tejada-Simon, V. M. Rivera, and J. Z. Zhang Aberrant T cell migration toward RANTES and MIP-1{alpha} in patients with multiple sclerosis: Overexpression of chemokine receptor CCR5 Brain, September 1, 2000; 123(9): 1874 - 1882. [Abstract] [Full Text] [PDF]
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 Y.-j. Zhang, B. Lou, R. B. Lal, A. Gettie, P. A. Marx, and J. P. Moore Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells J. Virol., August 1, 2000; 74(15): 6893 - 6910. [Abstract] [Full Text]
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S. Lee, H. L. Tiffany, L. King, P. M. Murphy, H. Golding, and M. B. Zaitseva CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor J. Virol., August 1, 2000; 74(15): 6946 - 6952. [Abstract] [Full Text]
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 L. H. Glimcher and K. M. Murphy Lineage commitment in the immune system: the T helper lymphocyte grows up Genes & Dev., July 15, 2000; 14(14): 1693 - 1711. [Full Text]
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D. Jones, C. O'Hara, M. D. Kraus, A. R. Perez-Atayde, A. Shahsafaei, L. Wu, and D. M. Dorfman Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma Blood, July 15, 2000; 96(2): 685 - 690. [Abstract] [Full Text] [PDF]
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R. A. Tripp, L. Jones, and L. J. Anderson Respiratory Syncytial Virus G and/or SH Glycoproteins Modify CC and CXC Chemokine mRNA Expression in the BALB/c Mouse J. Virol., July 1, 2000; 74(13): 6227 - 6229. [Abstract] [Full Text]
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S. Zhang, N. W. Lukacs, V. A. Lawless, S. L. Kunkel, and M. H. Kaplan Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat4 J. Immunol., July 1, 2000; 165(1): 10 - 14. [Abstract] [Full Text] [PDF]
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C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
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M. Inngjerdingen, B. Damaj, and A. A. Maghazachi Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-309 J. Immunol., April 15, 2000; 164(8): 4048 - 4054. [Abstract] [Full Text] [PDF]
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 P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]
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E. H. Tran, E. N. Prince, and T. Owens IFN-{gamma} Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines J. Immunol., March 1, 2000; 164(5): 2759 - 2768. [Abstract] [Full Text] [PDF]
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R. J. B. Nibbs, T. W. Salcedo, J. D. M. Campbell, X.-T. Yao, Y. Li, B. Nardelli, H. S. Olsen, T. S. Morris, A. E. I. Proudfoot, V. P. Patel, et al. C-C Chemokine Receptor 3 Antagonism by the {beta}-Chemokine Macrophage Inflammatory Protein 4, a Property Strongly Enhanced by an Amino-Terminal Alanine-Methionine Swap J. Immunol., February 1, 2000; 164(3): 1488 - 1497. [Abstract] [Full Text] [PDF]
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H. R. Luttichau, J. Stine, T. P. Boesen, A. H. Johnsen, D. Chantry, J. Gerstoft, and T. W. Schwartz A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum J. Exp. Med., January 3, 2000; 191(1): 171 - 180. [Abstract] [Full Text] [PDF]
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N. Sato, W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja Defects in the Generation of IFN-{gamma} Are Overcome to Control Infection with Leishmania donovani in CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1{alpha}-, or CCR2-Deficient Mice J. Immunol., November 15, 1999; 163(10): 5519 - 5525. [Abstract] [Full Text] [PDF]
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B. A. Zabel, W. W. Agace, J. J. Campbell, H. M. Heath, D. Parent, A. I. Roberts, E. C. Ebert, N. Kassam, S. Qin, M. Zovko, et al. Human G Protein-Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine-Mediated Chemotaxis J. Exp. Med., November 1, 1999; 190(9): 1241 - 1256. [Abstract] [Full Text] [PDF]
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L. Colantonio, A. Iellem, B. Clissi, R. Pardi, L. Rogge, F. Sinigaglia, and D. D'Ambrosio Upregulation of Integrin alpha 6/beta 1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells Blood, November 1, 1999; 94(9): 2981 - 2989. [Abstract] [Full Text] [PDF]
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J. M. Blander, I. Visintin, C. A. Janeway Jr., and R. Medzhitov {alpha}(1,3)-Fucosyltransferase VII and {alpha}(2,3)-Sialyltransferase IV Are Up-Regulated in Activated CD4 T Cells and Maintained After Their Differentiation into Th1 and Migration into Inflammatory Sites J. Immunol., October 1, 1999; 163(7): 3746 - 3752. [Abstract] [Full Text] [PDF]
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T. Kawai, M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. M. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES J. Immunol., September 15, 1999; 163(6): 3269 - 3278. [Abstract] [Full Text] [PDF]
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D. J. Dairaghi, R. A. Fan, B. E. McMaster, M. R. Hanley, and T. J. Schall HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8. AGONIST AND ANTAGONIST PROFILES OF VIRAL CHEMOKINES J. Biol. Chem., July 30, 1999; 274(31): 21569 - 21574. [Abstract] [Full Text] [PDF]
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M. J. Endres, C. G. Garlisi, H. Xiao, L. Shan, and J. A. Hedrick The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8 J. Exp. Med., June 21, 1999; 189(12): 1993 - 1998. [Abstract] [Full Text] [PDF]
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 K. E. Balashov, J. B. Rottman, H. L. Weiner, and W. W. Hancock CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions PNAS, June 8, 1999; 96(12): 6873 - 6878. [Abstract] [Full Text] [PDF]
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 S. L. Kunkel Promiscuous Chemokine Receptors and Their Redundant Ligands Play an Enigmatic Role during HIV-1 Infection Am. J. Respir. Cell Mol. Biol., May 1, 1999; 20(5): 859 - 860. [Full Text]
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Y.-j. Zhang and J. P. Moore Will Multiple Coreceptors Need To Be Targeted by Inhibitors of Human Immunodeficiency Virus Type 1 Entry? J. Virol., April 1, 1999; 73(4): 3443 - 3448. [Abstract] [Full Text]
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