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Departments of
*
Pathology and
Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Medical School, Ann Arbor, MI 48109
The increase in inner-city asthma among children appears to be due
to allergic responses to several allergens. Recent studies have
demonstrated that Ags derived from cockroaches are especially prominent
in these settings and a significant health concern for the induction of
asthma in children. In the present study, we have outlined the
development of a murine model of cockroach allergen-induced airway
disease and assessed specific mechanisms of the response, which
resembles atopic human asthma. The allergic responses in this model
include allergen-specific airway eosinophilia and significantly altered
airway physiology, which directly correlates with inflammation. We have
further utilized this allergen to establish primary and secondary
rechallenge stages of late phase hyperreactivity exacerbation. This
latter stage is characterized by greater changes in airway physiology
than the primary stage, and it is likely due to the preexisting
peribronchial inflammation present at the time of the second allergen
rechallenge. We have identified specific roles for CC chemokines during
these stages, with MIP-1
being an important eosinophil attractant
during the primary stage and eotaxin during the secondary rechallenge
stage. The development of these models allows the evaluation of
mediators involved in both stages of cockroach allergen challenge, as
well as the testing of specific therapeutic
modalities.
This article has been cited by other articles:
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  V. Dolgachev, B. C. Petersen, A. L. Budelsky, A. A. Berlin, and N. W. Lukacs Pulmonary IL-17E (IL-25) Production and IL-17RB+ Myeloid Cell-Derived Th2 Cytokine Production Are Dependent upon Stem Cell Factor-Induced Responses during Chronic Allergic Pulmonary Disease J. Immunol., November 1, 2009; 183(9): 5705 - 5715. [Abstract] [Full Text] [PDF]
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 V. A. Dolgachev, M. R. Ullenbruch, N. W. Lukacs, and S. H. Phan Role of Stem Cell Factor and Bone Marrow-Derived Fibroblasts in Airway Remodeling Am. J. Pathol., February 1, 2009; 174(2): 390 - 400. [Abstract] [Full Text] [PDF]
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 S. Nanua, S. M. Zick, J. E. Andrade, U. S. Sajjan, J. R. Burgess, N. W. Lukacs, and M. B. Hershenson Quercetin Blocks Airway Epithelial Cell Chemokine Expression Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 602 - 610. [Abstract] [Full Text] [PDF]
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 A. M. Das, K. G. Vaddi, K. A. Solomon, C. Krauthauser, X. Jiang, K. W. McIntyre, X. X. Yang, E. Wadman, P. Welch, M. Covington, et al. Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 411 - 417. [Abstract] [Full Text] [PDF]
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A. L. Miller, C. Gerard, M. Schaller, A. D. Gruber, A. A. Humbles, and N. W. Lukacs Deletion of CCR1 Attenuates Pathophysiologic Responses during Respiratory Syncytial Virus Infection J. Immunol., February 15, 2006; 176(4): 2562 - 2567. [Abstract] [Full Text] [PDF]
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 A. Mejias, S. Chavez-Bueno, A. M. Rios, M. F. Aten, B. Raynor, E. Peromingo, P. Soni, K. D. Olsen, P. A. Kiener, A. M. Gomez, et al. Comparative Effects of Two Neutralizing Anti-Respiratory Syncytial Virus (RSV) Monoclonal Antibodies in the RSV Murine Model: Time versus Potency Antimicrob. Agents Chemother., November 1, 2005; 49(11): 4700 - 4707. [Abstract] [Full Text] [PDF]
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 S. M. Pope, P. C. Fulkerson, C. Blanchard, H. S. Akei, N. M. Nikolaidis, N. Zimmermann, J. D. Molkentin, and M. E. Rothenberg Identification of a Cooperative Mechanism Involving Interleukin-13 and Eotaxin-2 in Experimental Allergic Lung Inflammation J. Biol. Chem., April 8, 2005; 280(14): 13952 - 13961. [Abstract] [Full Text] [PDF]
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S. K. Lundy, S. A. Lira, J. J. Smit, D. N. Cook, A. A. Berlin, and N. W. Lukacs Attenuation of Allergen-Induced Responses in CCR6-/- Mice Is Dependent upon Altered Pulmonary T Lymphocyte Activation J. Immunol., February 15, 2005; 174(4): 2054 - 2060. [Abstract] [Full Text] [PDF]
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A. E. John, M. S. Thomas, A. A. Berlin, and N. W. Lukacs Temporal Production of CCL28 Corresponds to Eosinophil Accumulation and Airway Hyperreactivity in Allergic Airway Inflammation Am. J. Pathol., February 1, 2005; 166(2): 345 - 353. [Abstract] [Full Text] [PDF]
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 A. A. Berlin and N. W. Lukacs Treatment of Cockroach Allergen Asthma Model with Imatinib Attenuates Airway Responses Am. J. Respir. Crit. Care Med., January 1, 2005; 171(1): 35 - 39. [Abstract] [Full Text] [PDF]
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R. L. Warner, N. W. Lukacs, S. D. Shapiro, N. Bhagarvathula, K. C. Nerusu, J. Varani, and K. J. Johnson Role of Metalloelastase in a Model of Allergic Lung Responses Induced by Cockroach Allergen Am. J. Pathol., December 1, 2004; 165(6): 1921 - 1930. [Abstract] [Full Text] [PDF]
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Z. Johnson, M. H. Kosco-Vilbois, S. Herren, R. Cirillo, V. Muzio, P. Zaratin, M. Carbonatto, M. Mack, A. Smailbegovic, M. Rose, et al. Interference with Heparin Binding and Oligomerization Creates a Novel Anti-Inflammatory Strategy Targeting the Chemokine System J. Immunol., November 1, 2004; 173(9): 5776 - 5785. [Abstract] [Full Text] [PDF]
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A. Mejias, S. Chavez-Bueno, A. M. Rios, J. Saavedra-Lozano, M. Fonseca Aten, J. Hatfield, P. Kapur, A. M. Gomez, H. S. Jafri, and O. Ramilo Anti-Respiratory Syncytial Virus (RSV) Neutralizing Antibody Decreases Lung Inflammation, Airway Obstruction, and Airway Hyperresponsiveness in a Murine RSV Model Antimicrob. Agents Chemother., May 1, 2004; 48(5): 1811 - 1822. [Abstract] [Full Text] [PDF]
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C. M. Schramm, L. Puddington, C. Wu, L. Guernsey, M. Gharaee-Kermani, S. H. Phan, and R. S. Thrall Chronic Inhaled Ovalbumin Exposure Induces Antigen-Dependent but Not Antigen-Specific Inhalational Tolerance in a Murine Model of Allergic Airway Disease Am. J. Pathol., January 1, 2004; 164(1): 295 - 304. [Abstract] [Full Text] [PDF]
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N. W. Lukacs, A. L. Miller, and C. M. Hogaboam Chemokine Receptors in Asthma: Searching for the Correct Immune Targets J. Immunol., July 1, 2003; 171(1): 11 - 15. [Full Text] [PDF]
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K. Raman, M. H. Kaplan, C. M. Hogaboam, A. Berlin, and N. W. Lukacs STAT4 Signal Pathways Regulate Inflammation and Airway Physiology Changes in Allergic Airway Inflammation Locally Via Alteration of Chemokines J. Immunol., April 1, 2003; 170(7): 3859 - 3865. [Abstract] [Full Text] [PDF]
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 S. H. P. Oliveira, D. D. Taub, J. Nagel, R. Smith, C. M. Hogaboam, A. Berlin, and N. W. Lukacs Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis Blood, December 15, 2002; 100(13): 4291 - 4297. [Abstract] [Full Text] [PDF]
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R. K. Kumar and P. S. Foster Modeling Allergic Asthma in Mice: Pitfalls and Opportunities Am. J. Respir. Cell Mol. Biol., September 1, 2002; 27(3): 267 - 272. [Abstract] [Full Text]
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N. W. Lukacs, A. John, A. Berlin, D. C. Bullard, R. Knibbs, and L. M. Stoolman E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses J. Immunol., August 15, 2002; 169(4): 2120 - 2125. [Abstract] [Full Text] [PDF]
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 J. M. Schuh, K. Blease, S. L. Kunkel, and C. M. Hogaboam Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L198 - L204. [Abstract] [Full Text] [PDF]
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 S. H. P. Oliveira, S. Lira, C. Martinez-A, M. Wiekowski, L. Sullivan, and N. W. Lukacs Increased responsiveness of murine eosinophils to MIP-1{beta} (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8 J. Leukoc. Biol., June 1, 2002; 71(6): 1019 - 1025. [Abstract] [Full Text] [PDF]
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M. T. Borchers, T. Ansay, R. DeSalle, B. L. Daugherty, H. Shen, M. Metzger, N. A. Lee, and J. J. Lee In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration J. Leukoc. Biol., June 1, 2002; 71(6): 1033 - 1041. [Abstract] [Full Text] [PDF]
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N. W. Lukacs, A. Berlin, D. Schols, R. T. Skerlj, and G. J. Bridger AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity Am. J. Pathol., April 1, 2002; 160(4): 1353 - 1360. [Abstract] [Full Text] [PDF]
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S. S. Cheng, N. W. Lukacs, and S. L. Kunkel Eotaxin/CCL11 Suppresses IL-8/CXCL8 Secretion from Human Dermal Microvascular Endothelial Cells J. Immunol., March 15, 2002; 168(6): 2887 - 2894. [Abstract] [Full Text] [PDF]
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H. F. Rosenberg and J. B. Domachowske Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens J. Leukoc. Biol., November 1, 2001; 70(5): 691 - 698. [Abstract] [Full Text] [PDF]
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L.-C. Chen, Z. Zhang, A. C. Myers, and S.-K. Huang Cutting Edge: Altered Pulmonary Eosinophilic Inflammation in Mice Deficient for Clara Cell Secretory 10-kDa Protein J. Immunol., September 15, 2001; 167(6): 3025 - 3028. [Abstract] [Full Text] [PDF]
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J. Kim, A. C. Merry, J. A. Nemzek, G. L. Bolgos, J. Siddiqui, and D. G. Remick Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens J. Immunol., September 1, 2001; 167(5): 2808 - 2815. [Abstract] [Full Text] [PDF]
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 N. W. Lukacs, D. M. Prosser, M. Wiekowski, S. A. Lira, and D. N. Cook Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation J. Exp. Med., August 20, 2001; 194(4): 551 - 556. [Abstract] [Full Text] [PDF]
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N. W. Lukacs, K. K. Tekkanat, A. Berlin, C. M. Hogaboam, A. Miller, H. Evanoff, P. Lincoln, and H. Maassab Respiratory Syncytial Virus Predisposes Mice to Augmented Allergic Airway Responses Via IL-13-Mediated Mechanisms J. Immunol., July 15, 2001; 167(2): 1060 - 1065. [Abstract] [Full Text] [PDF]
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 J.C. Kips Cytokines in asthma Eur. Respir. J., July 2, 2001; 18(34_suppl): 24S - 33s. [Abstract] [Full Text] [PDF]
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R.-F. Guo, A. B. Lentsch, R. L. Warner, M. Huber-Lang, J. V. Sarma, T. Hlaing, M. M. Shi, N. W. Lukacs, and P. A. Ward Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury J. Immunol., April 15, 2001; 166(8): 5208 - 5218. [Abstract] [Full Text] [PDF]
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N. W. Lukacs, M. M. Glovsky, and P. A. Ward Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L512 - L518. [Abstract] [Full Text] [PDF]
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N. Zimmermann, S. P. Hogan, A. Mishra, E. B. Brandt, T. R. Bodette, S. M. Pope, F. D. Finkelman, and M. E. Rothenberg Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression J. Immunol., November 15, 2000; 165(10): 5839 - 5846. [Abstract] [Full Text] [PDF]
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A. E. Dixon, J. B. Mandac, D. K. Madtes, P. J. Martin, and J. G. Clark Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma -inducible chemokines Am J Physiol Lung Cell Mol Physiol, September 1, 2000; 279(3): L592 - L599. [Abstract] [Full Text] [PDF]
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J. B. Domachowske, C. A. Bonville, J.-L. Gao, P. M. Murphy, A. J. Easton, and H. F. Rosenberg The Chemokine Macrophage-Inflammatory Protein-1{alpha} and Its Receptor CCR1 Control Pulmonary Inflammation and Antiviral Host Defense in Paramyxovirus Infection J. Immunol., September 1, 2000; 165(5): 2677 - 2682. [Abstract] [Full Text] [PDF]
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A. Trifilieff, Y. Fujitani, F. Mentz, B. Dugas, M. Fuentes, and C. Bertrand Inducible Nitric Oxide Synthase Inhibitors Suppress Airway Inflammation in Mice Through Down-Regulation of Chemokine Expression J. Immunol., August 1, 2000; 165(3): 1526 - 1533. [Abstract] [Full Text] [PDF]
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K. Blease, B. Mehrad, T. J. Standiford, N. W. Lukacs, S. L. Kunkel, S. W. Chensue, B. Lu, C. J. Gerard, and C. M. Hogaboam Airway Remodeling Is Absent in CCR1-/- Mice During Chronic Fungal Allergic Airway Disease J. Immunol., August 1, 2000; 165(3): 1564 - 1572. [Abstract] [Full Text] [PDF]
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A. Panoskaltsis-Mortari, R. M. Strieter, J. R. Hermanson, K. V. Fegeding, W. J. Murphy, C. L. Farrell, D. L. Lacey, and B. R. Blazar Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation Blood, August 1, 2000; 96(3): 834 - 839. [Abstract] [Full Text] [PDF]
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C. M. Hogaboam, K. Blease, B. Mehrad, M. L. Steinhauser, T. J. Standiford, S. L. Kunkel, and N. W. Lukacs Chronic Airway Hyperreactivity, Goblet Cell Hyperplasia, and Peribronchial Fibrosis during Allergic Airway Disease Induced by Aspergillus fumigatus Am. J. Pathol., February 1, 2000; 156(2): 723 - 732. [Abstract] [Full Text] [PDF]
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E. Campbell, S. L. Kunkel, R. M. Strieter, and N. W. Lukacs Differential Roles of IL-18 in Allergic Airway Disease: Induction of Eotaxin by Resident Cell Populations Exacerbates Eosinophil Accumulation J. Immunol., January 15, 2000; 164(2): 1096 - 1102. [Abstract] [Full Text] [PDF]
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A. E. I. Proudfoot, R. Buser, F. Borlat, S. Alouani, D. Soler, R. E. Offord, J.-M. Schroder, C. A. Power, and T. N. C. Wells Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors J. Biol. Chem., November 5, 1999; 274(45): 32478 - 32485. [Abstract] [Full Text] [PDF]
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M. E. Rothenberg Eotaxin . An Essential Mediator of Eosinophil Trafficking into Mucosal Tissues Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 291 - 295. [Full Text]
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H. Ochi, W. M. Hirani, Q. Yuan, D. S. Friend, K. F. Austen, and J. A. Boyce T Helper Cell Type 2 Cytokine-Mediated Comitogenic Responses and Ccr3 Expression during Differentiation of Human Mast Cells in Vitro J. Exp. Med., July 19, 1999; 190(2): 267 - 280. [Abstract] [Full Text] [PDF]
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C. M. Hogaboam, C. S. Gallinat, D. D. Taub, R. M. Strieter, S. L. Kunkel, and N. W. Lukacs Immunomodulatory Role of C10 Chemokine in a Murine Model of Allergic Bronchopulmonary Aspergillosis J. Immunol., May 15, 1999; 162(10): 6071 - 6079. [Abstract] [Full Text] [PDF]
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