| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,§
,§,§
Divisions of
*
Hematology/Oncology,
Human Cancer Genetics, and
Infectious Disease, Department of Internal Medicine, and
§
Department of Medical Microbiology and Immunology and the Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210;
¶
Division of Infectious Disease, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555; and
||
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263
Human NK cells have been shown to produce cytokines (e.g., IFN-
and TNF-
) and the chemokine macrophage inflammatory protein
(MIP)-1 following stimulation with the combination of two monokines,
IL-15 plus IL-12. The C-C chemokines MIP-1, MIP-1ß, and RANTES
have been identified as the major soluble macrophage-tropic
HIV-1-suppressive factors produced by CD8+ T cells, which
exert their action at the level of viral entry. Here, we demonstrate
that monokine-activated NK cells, isolated from both normal and
HIV-1+ donors, produce similar amounts of MIP-1,
MIP-1ß, and RANTES protein, in vitro. Further, supernatants of
monokine-activated NK cells obtained from both normal donors and AIDS
patients showed potent (routinely 
90%) suppressive activity against
HIV-1 replication in vitro, compared with unstimulated control
supernatants. NK cell supernatants inhibited both macrophage-tropic
HIV-1NFN-SX and T cell-tropic HIV-1NL4–3
replication in vitro, but not dual-tropic HIV-189.6.
Importantly, the C-C chemokines MIP-1, MIP-1ß, and RANTES were
responsible only for a fraction of the HIV-1-suppressive activity
exhibited by NK cell supernatants against macrophage-tropic HIV-1.
Collectively these data indicate that NK cells from normal and
HIV-1+ donors produce C-C chemokines and other unidentified
factors that can inhibit both macrophage- and T cell-tropic HIV-1
replication in vitro. Since NK cells can be expanded in patients with
HIV-1, AIDS, and AIDS malignancy in vivo, this cell type may have an
important role in the in vivo regulation of HIV-1
infection.
This article has been cited by other articles:
|
|
 |
|
  T. F. Mselle, A. L. Howell, M. Ghosh, C. R. Wira, and C. L. Sentman Human Uterine Natural Killer Cells but Not Blood Natural Killer Cells Inhibit Human Immunodeficiency Virus Type 1 Infection by Secretion of CXCL12 J. Virol., November 1, 2009; 83(21): 11188 - 11195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination J. Leukoc. Biol., July 1, 2008; 84(1): 27 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. I. Choi, K. A. Reimann, and N. L. Letvin In Vivo Natural Killer Cell Depletion during Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys J. Virol., July 1, 2008; 82(13): 6758 - 6761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Fulci, L. Breymann, D. Gianni, K. Kurozomi, S. S. Rhee, J. Yu, B. Kaur, D. N. Louis, R. Weissleder, M. A. Caligiuri, et al. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses PNAS, August 22, 2006; 103(34): 12873 - 12878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wei, J. W. Stallworth, P. J. Vance, J. A. Hoxie, and P. N. Fultz Simian Immunodeficiency Virus (SIV)/Immunoglobulin G Immune Complexes in SIV-Infected Macaques Block Detection of CD16 but Not Cytolytic Activity of Natural Killer Cells. Clin. Vaccine Immunol., July 1, 2006; 13(7): 768 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miyake, K. Ibuki, Y. Enose, H. Suzuki, R. Horiuchi, M. Motohara, N. Saito, T. Nakasone, M. Honda, T. Watanabe, et al. Rapid dissemination of a pathogenic simian/human immunodeficiency virus to systemic organs and active replication in lymphoid tissues following intrarectal infection. J. Gen. Virol., May 1, 2006; 87(Pt 5): 1311 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Nuvor, M. van der Sande, S. Rowland-Jones, H. Whittle, and A. Jaye Natural Killer Cell Function Is Well Preserved in Asymptomatic Human Immunodeficiency Virus Type 2 (HIV-2) Infection but Similar to That of HIV-1 Infection When CD4 T-Cell Counts Fall J. Virol., March 1, 2006; 80(5): 2529 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kottilil, K. Shin, J. O. Jackson, K. N. Reitano, M. A. O'Shea, J. Yang, C. W. Hallahan, R. Lempicki, J. Arthos, and A. S. Fauci Innate Immune Dysfunction in HIV Infection: Effect of HIV Envelope-NK Cell Interactions J. Immunol., January 15, 2006; 176(2): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Roda, R. Parihar, C. Magro, G. J. Nuovo, S. Tridandapani, and W. E. Carson III Natural Killer Cells Produce T Cell-Recruiting Chemokines in Response to Antibody-Coated Tumor Cells Cancer Res., January 1, 2006; 66(1): 517 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Alter, N. Teigen, B. T. Davis, M. M. Addo, T. J. Suscovich, M. T. Waring, H. Streeck, M. N. Johnston, K. D. Staller, M. T. Zaman, et al. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection Blood, November 15, 2005; 106(10): 3366 - 3369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Walzer, M. Dalod, S. H. Robbins, L. Zitvogel, and E. Vivier Natural-killer cells and dendritic cells: "l'union fait la force" Blood, October 1, 2005; 106(7): 2252 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Mueller, C. Petrovas, P. M. Bojczuk, I. D. Dimitriou, B. Beer, P. Silvera, F. Villinger, J. S. Cairns, E. J. Gracely, M. G. Lewis, et al. Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques J. Virol., April 15, 2005; 79(8): 4877 - 4885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mavilio, J. Benjamin, M. Daucher, G. Lombardo, S. Kottilil, M. A. Planta, E. Marcenaro, C. Bottino, L. Moretta, A. Moretta, et al. Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates PNAS, December 9, 2003; 100(25): 15011 - 15016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Maghazachi G protein-coupled receptors in natural killer cells J. Leukoc. Biol., July 1, 2003; 74(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Mueller, V. Makar, P. M. Bojczuk, J. Witek, and P. D. Katsikis IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells Int. Immunol., January 1, 2003; 15(1): 49 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Sandberg, N. M. Fast, E. H. Palacios, G. Fennelly, J. Dobroszycki, P. Palumbo, A. Wiznia, R. M. Grant, N. Bhardwaj, M. G. Rosenberg, et al. Selective Loss of Innate CD4+ V{alpha}24 Natural Killer T Cells in Human Immunodeficiency Virus Infection J. Virol., June 27, 2002; 76(15): 7528 - 7534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Azzoni, E. Papasavvas, J. Chehimi, J. R. Kostman, K. Mounzer, J. Ondercin, B. Perussia, and L. J. Montaner Sustained Impairment of IFN-{gamma} Secretion in Suppressed HIV-Infected Patients Despite Mature NK Cell Recovery: Evidence for a Defective Reconstitution of Innate Immunity J. Immunol., June 1, 2002; 168(11): 5764 - 5770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Robertson Role of chemokines in the biology of natural killer cells J. Leukoc. Biol., February 1, 2002; 71(2): 173 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Fehniger and M. A. Caligiuri Interleukin 15: biology and relevance to human disease Blood, January 1, 2001; 97(1): 14 - 32. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Olszewski, G. B. Huffnagle, R. A. McDonald, D. M. Lindell, B. B. Moore, D. N. Cook, and G. B. Toews The Role of Macrophage Inflammatory Protein-1{alpha}/CCL3 in Regulation of T Cell-Mediated Immunity to Cryptococcus neoformans Infection J. Immunol., December 1, 2000; 165(11): 6429 - 6436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cipriani, G. Borsellino, F. Poccia, R. Placido, D. Tramonti, S. Bach, L. Battistini, and C. F. Brosnan Activation of C-C beta -chemokines in human peripheral blood gamma delta T cells by isopentenyl pyrophosphate and regulation by cytokines Blood, January 1, 2000; 95(1): 39 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gosselin, A. TomoIu, R. C. Gallo, and L. Flamand Interleukin-15 as an Activator of Natural Killer Cell-Mediated Antiviral Response Blood, December 15, 1999; 94(12): 4210 - 4219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Fehniger, M. H. Shah, M. J. Turner, J. B. VanDeusen, S. P. Whitman, M. A. Cooper, K. Suzuki, M. Wechser, F. Goodsaid, and M. A. Caligiuri Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response J. Immunol., April 15, 1999; 162(8): 4511 - 4520. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
