| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Microbiology and Immunology, University of Adelaide, Adelaide, Australia;
Neurosciences Research Unit, Canberra Hospital, Canberra, Australia; and
Division of Molecular Medicine, John Curtin School of Medical Research, Acton, Australia
Emerging data suggest that polymorphonuclear leukocytes (PMNLs) can play an important role in Ag-dependent immune responses. Therefore, we have assessed the involvement of these cells in the development of an organ-specific autoimmune disease, experimental autoimmune encephalomyelitis (EAE), in the mouse. Depletion of peripheral blood PMNLs beginning day 8 after immunization significantly delayed and in some cases totally prevented the development of clinical EAE in mice. Depletion of PMNLs beginning 1 day before sensitization and continuing until day 7 postimmunization had no effect on the subsequent development of EAE, suggesting that depletion alters the efferent but not the afferent arm of the immune response. In vitro studies showed that lymphoid cells from mice protected from EAE by PMNL depletion beginning on day 8 postsensitization proliferated in response to specific Ag to a level equal to cells from sensitized animals treated with control serum, again indicating that treatment was not affecting the afferent limb of the immune response. Further evidence that PMNL may be necessary in initiating the pathology of EAE was seen in passive transfer experiments where PMNL-depleted recipients of MBP-specific lymphoid effector cells developed EAE much less effectively than did animals treated with control Ab. Taken together, these data indicate that PMNLs play a critical role in the effector phase of the development of the clinicopathologic expression of EAE in mice.
This article has been cited by other articles:
|
|
 |
|
  K. M. Omari, S. E. Lutz, L. Santambrogio, S. A. Lira, and C. S. Raine Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1 Am. J. Pathol., January 1, 2009; 174(1): 164 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Kroenke, T. J. Carlson, A. V. Andjelkovic, and B. M. Segal IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J. Exp. Med., July 7, 2008; 205(7): 1535 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Carlson, M. Kroenke, P. Rao, T. E. Lane, and B. Segal The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease J. Exp. Med., April 14, 2008; 205(4): 811 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Folgueras, A. Fueyo, O. Garcia-Suarez, J. Cox, A. Astudillo, P. Tortorella, C. Campestre, A. Gutierrez-Fernandez, M. Fanjul-Fernandez, C. J. Pennington, et al. Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice J. Biol. Chem., April 4, 2008; 283(14): 9465 - 9474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. C. Ireland, S. A. Stohlman, D. R. Hinton, R. Atkinson, and C. C. Bergmann Type I Interferons Are Essential in Controlling Neurotropic Coronavirus Infection Irrespective of Functional CD8 T Cells J. Virol., January 1, 2008; 82(1): 300 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Su, R. S. Grajewski, D. Luger, R. K. Agarwal, P. B. Silver, J. Tang, J. Tuo, C.-C. Chan, and R. R. Caspi Altered Chemokine Profile Associated with Exacerbated Autoimmune Pathology under Conditions of Genetic Interferon-{gamma} Deficiency Invest. Ophthalmol. Vis. Sci., October 1, 2007; 48(10): 4616 - 4625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Dietlin, F. M. Hofman, B. T. Lund, W. Gilmore, S. A. Stohlman, and R. C. van der Veen Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion J. Leukoc. Biol., May 1, 2007; 81(5): 1205 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Gimenez, J. Sim, A. S. Archambault, R. S. Klein, and J. H. Russell A Tumor Necrosis Factor Receptor 1-Dependent Conversation between Central Nervous System-Specific T Cells and the Central Nervous System Is Required for Inflammatory Infiltration of the Spinal Cord Am. J. Pathol., April 1, 2006; 168(4): 1200 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Baranzini, C. C. A. Bernard, and J. R. Oksenberg Modular Transcriptional Activity Characterizes the Initiation and Progression of Autoimmune Encephalomyelitis J. Immunol., June 1, 2005; 174(11): 7412 - 7422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Zehntner, C. Brickman, L. Bourbonniere, L. Remington, M. Caruso, and T. Owens Neutrophils That Infiltrate the Central Nervous System Regulate T Cell Responses J. Immunol., April 15, 2005; 174(8): 5124 - 5131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Molesworth-Kenyon, J. E. Oakes, and R. N. Lausch A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen J. Leukoc. Biol., April 1, 2005; 77(4): 552 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Bonder, M. N. Ajuebor, L. D. Zbytnuik, P. Kubes, and M. G. Swain Essential Role for Neutrophil Recruitment to the Liver in Concanavalin A-Induced Hepatitis J. Immunol., January 1, 2004; 172(1): 45 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Djerbi, K.-B. Abdul-Majid, M. Abedi-Valugerdi, T. Olsson, R. A. Harris, and A. Grandien Expression of the Long Form of Human FLIP by Retroviral Gene Transfer of Hemopoietic Stem Cells Exacerbates Experimental Autoimmune Encephalomyelitis J. Immunol., February 15, 2003; 170(4): 2064 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhu, L. Luo, Y. Chen, D. W. Paty, and M. S. Cynader Intrathecal Fas Ligand Infusion Strengthens Immunoprivilege of Central Nervous System and Suppresses Experimental Autoimmune Encephalomyelitis J. Immunol., August 1, 2002; 169(3): 1561 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. McQualter, R. Darwiche, C. Ewing, M. Onuki, T. W. Kay, J. A. Hamilton, H. H. Reid, and C. C.A. Bernard Granulocyte Macrophage Colony-Stimulating Factor: A New Putative Therapeutic Target in Multiple Sclerosis J. Exp. Med., October 1, 2001; 194(7): 873 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kielian, B. Barry, and W. F. Hickey CXC Chemokine Receptor-2 Ligands Are Required for Neutrophil-Mediated Host Defense in Experimental Brain Abscesses1 J. Immunol., April 1, 2001; 166(7): 4634 - 4643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Hoek, S. R. Ruuls, C. A. Murphy, G. J. Wright, R. Goddard, S. M. Zurawski, B. Blom, M. E. Homola, W. J. Streit, M. H. Brown, et al. Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200) Science, December 1, 2000; 290(5497): 1768 - 1771. [Abstract] [Full Text]
|
|
|
|
|
|
L. S. Cauley, E. E. Miller, M. Yen, and S. L. Swain Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-{gamma} J. Immunol., December 1, 2000; 165(11): 6056 - 6066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Luo, F. R. Fischer, W. W. Hancock, and M. E. Dorf Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes J. Immunol., October 1, 2000; 165(7): 4015 - 4023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Q. Chu, S. Wittmer, and D. K. Dalton Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon {gamma}-Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis J. Exp. Med., July 3, 2000; 192(1): 123 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. de Oca, A. J. Buendia, L. Del Rio, J. Sanchez, J. Salinas, and J. A. Navarro Polymorphonuclear Neutrophils Are Necessary for the Recruitment of CD8+ T Cells in the Liver in a Pregnant Mouse Model of Chlamydophila abortus (Chlamydia psittaci Serotype 1) Infection Infect. Immun., March 1, 2000; 68(3): 1746 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Tran, E. N. Prince, and T. Owens IFN-{gamma} Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines J. Immunol., March 1, 2000; 164(5): 2759 - 2768. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
