HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Uzonna, J. E. Articles by Tabel, H. Search for Related Content PubMed PubMed Citation Articles by Uzonna, J. E. Articles by Tabel, H.

Experimental Murine Trypanosoma congolense Infections. II. Role of Splenic Adherent CD3⁺ Thy1.2⁺ TCR-ß^{- -} CD4⁺8^- and CD3⁺ Thy1.2⁺ TCR-ß^{- -} CD4^-8^- Cells in the Production of IL-4, IL-10, and IFN- and in Trypanosome-Elicited Immunosuppression¹

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada

Trypanosome-induced suppression of T and B cell responses to parasite-related and -unrelated Ags is considered a major mechanism of evasion of the host’s immune defenses by the parasite. Reduced T and B cell responses have been attributed to suppressor T cells, suppressor macrophages, or both. We have previously shown that endogenously produced IL-10 and IFN- mediate the suppression of T cell responses in Trypanosoma congolense-infected mice. Here, we show for the first time that splenic CD3⁺ Thy1.2⁺ ß^{- -} CD4⁺8^- and CD3⁺ Thy1.2⁺ ß^{- -} CD4^-8^- cells that copurify with plastic-, nylon wool-, or Sephadex G-10-adherent cell populations, in synergy with adherent Thy1.2^- cells, are the major producers of IL-4, IL-10, and IFN- in T. congolense-infected mice. We further demonstrate the involvement of these cells in the suppression of T cell proliferative responses to mitogen and in B cell responses to a parasite-unrelated Ag.

This article has been cited by other articles:

				G. Wei and H. Tabel Regulatory T Cells Prevent Control of Experimental African Trypanosomiasis J. Immunol., February 15, 2008; 180(4): 2514 - 2521. [Abstract] [Full Text] [PDF]

				E. S. Bernardes, N. M. Silva, L. P. Ruas, J. R. Mineo, A. M. Loyola, D. K. Hsu, F.-T. Liu, R. Chammas, and M. C. Roque-Barreira Toxoplasma gondii Infection Reveals a Novel Regulatory Role for Galectin-3 in the Interface of Innate and Adaptive Immunity Am. J. Pathol., June 1, 2006; 168(6): 1910 - 1920. [Abstract] [Full Text] [PDF]

				M. Shi, G. Wei, W. Pan, and H. Tabel Experimental African Trypanosomiasis: A Subset of Pathogenic, IFN-{gamma}-Producing, MHC Class II-Restricted CD4+ T Cells Mediates Early Mortality in Highly Susceptible Mice J. Immunol., February 1, 2006; 176(3): 1724 - 1732. [Abstract] [Full Text] [PDF]

				Y. Lu, Y.-q. Wei, L. Tian, X. Zhao, L. Yang, B. Hu, B. Kan, Y.-j. Wen, F. Liu, H.-x. Deng, et al. Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor J. Immunol., March 15, 2003; 170(6): 3162 - 3170. [Abstract] [Full Text] [PDF]