| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Medicine, Columbia University, New York, NY 10032
CD40 activation of B cells is strongly influenced by the presence
of cytokines. However, the molecular basis for the interplay between
these distinct stimuli is not clearly delineated. IFN regulatory factor
1 (IRF-1) is a transcription factor activated by either CD40 or
cytokines. We have found that these different sets of signals target a
common cis-acting element in the promoter of this gene,
the IRF-1 gamma-activated site (GAS). Targeting of the IRF-1 GAS is not
confined to activation via CD40 but extends to other stimuli that mimic
the CD40 signaling cascade, like TNF-
and EBV. In contrast to
induction of STATs by cytokines, the IRF-1 GAS-binding complex
activated by CD40, TNF-, or EBV contains Rel proteins,
specifically p50 and p65. In this system, simultaneous exposure to
CD40L together with either IL-4 or IFN-
does not lead to the
activation of novel Rel/STAT complexes. Given the importance of IRF-1
in a variety of biologic functions from proliferation to apoptosis, our
findings support the notion that modulation of IRF-1 levels may be a
critical control point in B cell activation.
This article has been cited by other articles:
|
|
 |
|
  K. A. Shirey, J.-Y. Jung, and J. M. Carlin Up-Regulation of Gamma Interferon Receptor Expression Due to Chlamydia-Toll-Like Receptor Interaction Does Not Enhance Signal Transducer and Activator of Transcription 1 Signaling Infect. Immun., December 1, 2006; 74(12): 6877 - 6884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pizzoferrato, Y. Liu, A. Gambotto, M. J. Armstrong, M. T. Stang, W. E. Gooding, S. M. Alber, S. H. Shand, S. C. Watkins, W. J. Storkus, et al. Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin Cancer Res., November 15, 2004; 64(22): 8381 - 8388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. He, X. Qiao, and A. Cerutti CpG DNA Induces IgG Class Switch DNA Recombination by Activating Human B Cells through an Innate Pathway That Requires TLR9 and Cooperates with IL-10 J. Immunol., October 1, 2004; 173(7): 4479 - 4491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, J. C. Fanzo, C. Hu, D. Cox, S. Y. Jang, A. E. Lee, S. Greenberg, and A. B. Pernis T Cell Receptor Engagement Leads to the Recruitment of IBP, a Novel Guanine Nucleotide Exchange Factor, to the Immunological Synapse J. Biol. Chem., October 31, 2003; 278(44): 43541 - 43549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. TURECI, H. BIAN, F. O. NESTLE, L. RADDRIZZANI, J. A. ROSINSKI, A. TASSIS, H. HILTON, M. WALSTEAD, U. SAHIN, and J. HAMMER Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis FASEB J, May 1, 2003; 17(8): 836 - 847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Hu, S. Y. Jang, J. C. Fanzo, and A. B. Pernis Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4 J. Biol. Chem., December 13, 2002; 277(51): 49238 - 49246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Blair, L. B. Maggi Jr., A. L. Scarim, and J. A. Corbett Role of Interferon Regulatory Factor-1 in Double-stranded RNA-induced iNOS Expression by Mouse Islets J. Biol. Chem., January 4, 2002; 277(1): 359 - 365. [Abstract] [Full Text]
|
|
|
|
|
|
J. G. Bode, R. Fischer, D. Haussinger, L. Graeve, P. C. Heinrich, and F. Schaper The Inhibitory Effect of IL-1{beta} on IL-6-Induced {alpha}2-Macroglobulin Expression Is Due to Activation of NF-{kappa}B J. Immunol., August 1, 2001; 167(3): 1469 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Streetz, B. Fregien, J. Plumpe, K. Korber, S. Kubicka, G. Sass, S. C. Bischoff, M. P. Manns, G. Tiegs, and C. Trautwein Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor-1 in Con A-Induced Liver Failure J. Immunol., July 1, 2001; 167(1): 514 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Croy, A. A. Ashkar, K. Minhas, and J. D. Greenwood Can Murine Uterine Natural Killer Cells Give Insights Into the Pathogenesis of Preeclampsia? Reproductive Sciences, January 1, 2000; 7(1): 12 - 20. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Gupta, M. Jiang, A. Anthony, and A. B. Pernis Lineage-Specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4 J. Exp. Med., December 20, 1999; 190(12): 1837 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta, M. Jiang, and A. B. Pernis IFN-{alpha} Activates Stat6 and Leads to the Formation of Stat2:Stat6 Complexes in B Cells J. Immunol., October 1, 1999; 163(7): 3834 - 3841. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
