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T Cell Development
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
T cells belong to two distinct lineages expressing either 
ß or
TCR. During ß T cell development, it is clearly established
that productive rearrangement at the TCR ß locus in immature
precursor cells leads to the expression of a pre-TCR complex. Signaling
through the pre-TCR results in the selective proliferation and
maturation of TCR ß+ cells, a process that is known as
ß-selection. However, the potential role of ß-selection during
T cell development is controversial. Whereas PCR-RFLP and
sequencing techniques have provided evidence for a bias toward in-frame
VDJß rearrangements in cells (consistent with ß-selection),
cells apparently develop normally in mice that are unable to
assemble a pre-TCR complex due to a deficiency in TCR ß or pT
genes. In this report, we have directly addressed the physiologic
significance of ß-selection during cell development in normal
mice by quantitating intracellular TCR ß protein in cells and
correlating its presence with cell cycle status. Our results indicate
that ß-selection plays a significant (although limited) role in
cell development by selectively amplifying a minor subset of
precursor cells with productively rearranged TCR ß
genes.
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