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CUTTING EDGE |
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
Human NK cells cultured in the presence of IL-12 or IL-4
differentiate into cell populations with distinct patterns of cytokine
secretion similar to Th1 and Th2 cells. NK cells grown in IL-12 (NK1)
produce IL-10 and IFN-
, whereas NK cells grown in IL-4 (NK2) produce
IL-5 and IL-13. Although these NK cell subsets do not differ in
cytotoxic activity, NK1 cells express higher levels of cell surface
CD95 (Fas) Ag than NK2 cells and are more sensitive to Ab or chemically
induced apoptosis. Like Th1 cells, NK1 cells accumulate much
higher levels of the IL-12Rß2-chain mRNA and are significantly more
responsive to IL-12 than NK2 cells at the level of activation of STAT4
transcription factor. The identification of NK cell subsets that are
analogous to T cell subsets suggests a new role for NK cells in innate
inflammatory responses and in their effect on adaptive
immunity.
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