The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wise, M. P.
Right arrow Articles by Waldmann, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wise, M. P.
Right arrow Articles by Waldmann, H.
The Journal of Immunology, 1998, 161: 5813-5816.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Linked Suppression of Skin Graft Rejection Can Operate Through Indirect Recognition1

Matt P. Wise, Frederike Bemelman, Steve P. Cobbold and Herman Waldmann2

Dunn School of Pathology, South Parks Road, Oxford, United Kingdom

Adult mice can be rendered immunologically tolerant of allogeneic tissues if transplanted under cover of mAbs to CD4 and CD8. Tolerance generated in this manner is characterized by the presence of regulatory CD4+ T cells that can recruit naive T cells to become tolerant also through "infectious tolerance." Regulatory CD4+ T cells can also suppress rejection of third party transplant Ags provided they are expressed on the same graft as the tolerated Ags. This process of linked suppression can act across whole MHC barriers and represents a powerful mechanism with therapeutic potential. Tolerance can also be induced to reprocessed minor transplantation Ags presented through host APCs (indirect recognition). We here demonstrate that linked suppression can also be induced through the indirect pathway. This finding may be important in the development of transplantation tolerance in the clinic.




This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
X. Huang, D. J. Moore, R. J. Ketchum, C. S. Nunemaker, B. Kovatchev, A. L. McCall, and K. L. Brayman
Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation
Endocr. Rev., August 1, 2008; 29(5): 603 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Verginis, K. A. McLaughlin, K. W. Wucherpfennig, H. von Boehmer, and I. Apostolou
Induction of antigen-specific regulatory T cells in wild-type mice: Visualization and targets of suppression
PNAS, March 4, 2008; 105(9): 3479 - 3484.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Kapp, K. Honjo, L. M. Kapp, K. Goldsmith, and R. P. Bucy
Antigen, in the Presence of TGF-beta, Induces Up-Regulation of FoxP3gfp+ in CD4+ TCR Transgenic T Cells That Mediate Linked Suppression of CD8+ T Cell Responses
J. Immunol., August 15, 2007; 179(4): 2105 - 2114.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. F. Yates, A. M. Paterson, K. F. Nolan, S. P. Cobbold, N. J. Saunders, H. Waldmann, and P. J. Fairchild
Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation
J. Immunol., July 15, 2007; 179(2): 967 - 976.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. J. Callaghan, F. J. Rouhani, M. C. Negus, A. J. Curry, E. M. Bolton, J. A. Bradley, and G. J. Pettigrew
Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity
J. Immunol., February 15, 2007; 178(4): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Golshayan, S. Jiang, J. Tsang, M. I. Garin, C. Mottet, and R. I. Lechler
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
Blood, January 15, 2007; 109(2): 827 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. A. Kapp, K. Honjo, L. M. Kapp, X. y. Xu, A. Cozier, and R. P. Bucy
TCR transgenic CD8+ T cells activated in the presence of TGF{beta} express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection
Int. Immunol., November 1, 2006; 18(11): 1549 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. K. Asiedu, K. J. Goodwin, G. Balgansuren, S. M. Jenkins, S. Le Bas-Bernardet, U. Jargal, D. M. Neville Jr, and J. M. Thomas
Elevated T Regulatory Cells in Long-Term Stable Transplant Tolerance in Rhesus Macaques Induced by Anti-CD3 Immunotoxin and Deoxyspergualin
J. Immunol., December 15, 2005; 175(12): 8060 - 8068.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. B. Herrera, D. Golshayan, R. Tibbott, F. S. Ochoa, M. J. James, F. M. Marelli-Berg, and R. I. Lechler
A Novel Pathway of Alloantigen Presentation by Dendritic Cells
J. Immunol., October 15, 2004; 173(8): 4828 - 4837.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Graca, A. Le Moine, C.-Y. Lin, P. J. Fairchild, S. P. Cobbold, and H. Waldmann
Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells
PNAS, July 6, 2004; 101(27): 10122 - 10126.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Vigouroux, E. Yvon, E. Biagi, and M. K. Brenner
Antigen-induced regulatory T cells
Blood, July 1, 2004; 104(1): 26 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. L. Sumpter and D. S. Wilkes
Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1129 - L1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T.-C. Chen, S. P. Cobbold, P. J. Fairchild, and H. Waldmann
Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen
J. Immunol., May 15, 2004; 172(10): 5900 - 5907.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Mirenda, I. Berton, J. Read, T. Cook, J. Smith, A. Dorling, and R. I. Lechler
Modified Dendritic Cells Coexpressing Self and Allogeneic Major Histocompatability Complex Molecules: An Efficient Way to Induce Indirect Pathway Regulation
J. Am. Soc. Nephrol., April 1, 2004; 15(4): 987 - 997.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Jiang, N. Camara, G. Lombardi, and R. I. Lechler
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo
Blood, September 15, 2003; 102(6): 2180 - 2186.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Zhai and J. W. Kupiec-Weglinski
Regulatory T Cells in Kidney Transplant Recipients: Active Players but to What Extent?
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1706 - 1708.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
E. V. Fedoseyeva, K. Kishimoto, H. K. Rolls, B. M.-W. Illigens, V. M. Dong, A. Valujskikh, P. S. Heeger, M. H. Sayegh, and G. Benichou
Modulation of Tissue-Specific Immune Response to Cardiac Myosin Can Prolong Survival of Allogeneic Heart Transplants
J. Immunol., August 1, 2002; 169(3): 1168 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Graca, S. Thompson, C.-Y. Lin, E. Adams, S. P. Cobbold, and H. Waldmann
Both CD4+CD25+ and CD4+CD25- Regulatory Cells Mediate Dominant Transplantation Tolerance
J. Immunol., June 1, 2002; 168(11): 5558 - 5565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Chiffoleau, G. Beriou, P. Dutartre, C. Usal, J.-P. Soulillou, and M. C. Cuturi
Role for Thymic and Splenic Regulatory CD4+ T Cells Induced by Donor Dendritic Cells in Allograft Tolerance by LF15-0195 Treatment
J. Immunol., May 15, 2002; 168(10): 5058 - 5069.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Yamada, A. Chandraker, T. M. Laufer, A. J. Gerth, M. H. Sayegh, and H. Auchincloss Jr.
Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory Blockade
J. Immunol., November 15, 2001; 167(10): 5522 - 5526.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Leon, R. Perez, A. Lage, and J. Carneiro
Three-Cell Interactions in T Cell-Mediated Suppression? A Mathematical Analysis of Its Quantitative Implications
J. Immunol., May 1, 2001; 166(9): 5356 - 5365.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1998 by The American Association of Immunologists, Inc. All rights reserved.