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The Journal of Immunology, 1998, 161: 5809-5812.
Copyright © 1998 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Identification of the 2B4 Molecule as a Counter-Receptor for CD481

Yvette Latchman, Paul F. McKay and Hans Reiser2

Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

The CD48 molecule belongs to a subfamily of the Ig superfamily that also includes the CD2, CD58, 2B4, Signaling lymphocyte activation molecule (SLAM), and Ly-9 molecules. Receptor-ligand interactions are known to occur between several members of this family, and these interactions can strengthen cell to cell adhesion. In mice, the CD48 molecule can bind to CD2. To search for additional ligands of murine CD48, we have generated a chimeric fusion protein consisting of the extracellular domain of murine CD48 and the C region of human IgG1. The results of immunofluorescence and immunoprecipitation experiments in which this reagent was used identify the 2B4 molecule as a novel counter-receptor of CD48.




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