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CUTTING EDGE |
*
Inheritance and Variation Group, PREST, JST, Kyoto, Japan;
Division of Molecular Biology, Research Institute for Biological Sciences, Science University of Tokyo, Chiba, Japan; and
Department of Veterinary Pathology, University of Tokyo, Tokyo, Japan
The bursa of Fabricius is a gut-associated lymphoid organ that is essential for the generation of a diversified B cell repertoire in the chicken. We describe here a novel gene preferentially expressed in bursal B cells. The gene encodes an 85-kDa protein, designated BASH (B cell adaptor containing SH2 domain), that contains N-terminal acidic domains with SH2 domain-binding phosphotyrosine-based motifs, a proline-rich domain, and a C-terminal SH2 domain. BASH shows a substantial sequence similarity to SLP-76, an adaptor protein functioning in TCR-signal transduction. BASH becomes tyrosine-phosphorylated with the B cell Ag receptor (BCR) cross-link or by coexpression with Syk and Lyn and associates with signaling molecules including Syk and a putative chicken Shc homologue. Overexpression of BASH results in suppression of the NF-AT activation induced by BCR-cross-linking. These findings suggest that BASH is involved in BCR-mediated signal transduction and could play a critical role in B cell development in the bursa.
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R. Goitsuka, H. Kanazashi, H. Sasanuma, Y.-i. Fujimura, Y. Hidaka, A. Tatsuno, C. Ra, K. Hayashi, and D. Kitamura A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation Int. Immunol., April 1, 2000; 12(4): 573 - 580. [Abstract] [Full Text] [PDF]
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M. Y. Cao, D. Davidson, J. Yu, S. Latour, and A. Veillette Clnk, a Novel Slp-76-Related Adaptor Molecule Expressed in Cytokine-Stimulated Hemopoietic Cells J. Exp. Med., November 15, 1999; 190(10): 1527 - 1534. [Abstract] [Full Text] [PDF]
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J. Wong, M. Ishiai, T. Kurosaki, and A. C. Chan Functional Complementation of BLNK by SLP-76 and LAT Linker Proteins J. Biol. Chem., October 13, 2000; 275(42): 33116 - 33122. [Abstract] [Full Text] [PDF]
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J. E.-L. Tan, S.-C. Wong, S. K.-E. Gan, S. Xu, and K.-P. Lam The Adaptor Protein BLNK Is Required for B Cell Antigen Receptor-induced Activation of Nuclear Factor-kappa B and Cell Cycle Entry and Survival of B Lymphocytes J. Biol. Chem., June 1, 2001; 276(23): 20055 - 20063. [Abstract] [Full Text] [PDF]
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R. Goitsuka, A. Tatsuno, M. Ishiai, T. Kurosaki, and D. Kitamura MIST Functions through Distinct Domains in Immunoreceptor Signaling in the Presence and Absence of LAT J. Biol. Chem., September 14, 2001; 276(38): 36043 - 36050. [Abstract] [Full Text] [PDF]
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K. Sauer, J. Liou, S. B. Singh, D. Yablonski, A. Weiss, and R. M. Perlmutter Hematopoietic Progenitor Kinase 1 Associates Physically and Functionally with the Adaptor Proteins B Cell Linker Protein and SLP-76 in Lymphocytes J. Biol. Chem., November 21, 2001; 276(48): 45207 - 45216. [Abstract] [Full Text] [PDF]
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K. Hayashi, R. Nittono, N. Okamoto, S. Tsuji, Y. Hara, R. Goitsuka, and D. Kitamura The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells PNAS, March 14, 2000; 97(6): 2755 - 2760. [Abstract] [Full Text] [PDF]
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Y. Baba, S. Hashimoto, M. Matsushita, D. Watanabe, T. Kishimoto, T. Kurosaki, and S. Tsukada BLNK mediates Syk-dependent Btk activation PNAS, February 27, 2001; 98(5): 2582 - 2586. [Abstract] [Full Text] [PDF]
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